Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775587
Funder
Australian Research Council
Funding Amount
$532,000.00
Summary
Correlating Genomics and Proteomics for Systems Biology: integrating the '-omics'. Acquisition of the infrastructure requested will maintain and extend the expertise developed by researchers in NSW and will allow retention and attraction of leading researchers who can contribute to understanding how genes and proteins interact in the development of the organism - the central focus of systems biology. The enhancement of the facility will allow a better understanding of biomolecular interactions ....Correlating Genomics and Proteomics for Systems Biology: integrating the '-omics'. Acquisition of the infrastructure requested will maintain and extend the expertise developed by researchers in NSW and will allow retention and attraction of leading researchers who can contribute to understanding how genes and proteins interact in the development of the organism - the central focus of systems biology. The enhancement of the facility will allow a better understanding of biomolecular interactions in health and disease, providing both community and national benefits. The focus of this LIEF application is to provide infrastructure platforms for the study of the systems biology of organisms and additional capacity by the facility for the expected increased demand for this technology in this new area. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561013
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
X-ray diffraction System for Protein Crystallography and Structural Biology. Knowledge of protein structures enables researchers to explain cellular function at a molecular level. In particular, it provides essential information to understand the mechanism of diseases, such as cancer or AIDS, and it ultimately leads to the design of better drugs.
An in-house X-ray protein crystallography facility will allow us to determine the structures of key proteins effectively and competitively, opening up ....X-ray diffraction System for Protein Crystallography and Structural Biology. Knowledge of protein structures enables researchers to explain cellular function at a molecular level. In particular, it provides essential information to understand the mechanism of diseases, such as cancer or AIDS, and it ultimately leads to the design of better drugs.
An in-house X-ray protein crystallography facility will allow us to determine the structures of key proteins effectively and competitively, opening up extensive possibilities for multi-disciplinary ground-breaking research.
The University research portfolio has evolved to embrace the revolution in structural biology with numerous projects and collaborations focusing on proteins involved in bacterial infections, degenerative disorders and biotechnological applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775534
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
A liquid chromatograph-mass spectrometer for plant metabolomics. The Australian Agrifood sector will benefit significantly from the establishment of functional genomics platform technologies, such as metabolomics, that underpin 'Systems Biology'; a new branch of biology that attempts to discover and understand biological properties that emerge from the interactions of many system elements. Australian agriculture will benefit through the development of techniques to improve both yield and quality ....A liquid chromatograph-mass spectrometer for plant metabolomics. The Australian Agrifood sector will benefit significantly from the establishment of functional genomics platform technologies, such as metabolomics, that underpin 'Systems Biology'; a new branch of biology that attempts to discover and understand biological properties that emerge from the interactions of many system elements. Australian agriculture will benefit through the development of techniques to improve both yield and quality through minimising the effects of abiotic and biotic stresses, and a reduced dependence on inputs (eg fertilisers) leading to environmentally sustainable production systems. Ultimately this will result in enhanced food quality and analytical methods to monitor quality and safety characteristics of food.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668439
Funder
Australian Research Council
Funding Amount
$730,000.00
Summary
Elemental and Structural Analysis Facility Comprising a FTICR Mass Spectrometer and a CHNS Analyser. The determination of molecular structure is important in many fields of chemistry, biochemistry and material science. Without such determinations much chemical research would be viewed as incomplete and rendered unpatentable as well as unpublishable. The two state-of-the-art instruments to be purchased will improve the ability of a wide cross-section of researchers to rapidly characterize compoun ....Elemental and Structural Analysis Facility Comprising a FTICR Mass Spectrometer and a CHNS Analyser. The determination of molecular structure is important in many fields of chemistry, biochemistry and material science. Without such determinations much chemical research would be viewed as incomplete and rendered unpatentable as well as unpublishable. The two state-of-the-art instruments to be purchased will improve the ability of a wide cross-section of researchers to rapidly characterize compounds important in fields as varied as medicinal chemistry, material science and geosciences. All types of chemical research, from fundamental to applied, will benefit from these instruments with clear and positive implications regarding societal impact.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882778
Funder
Australian Research Council
Funding Amount
$201,224.00
Summary
Water vapour radiometers for millimetre-wave phase correction for the Australia Telescope. Australia has a tradition of excellence in astronomy. Inspired by wonder about the cosmos, it stimulates public interest in science, so leading to the training of highly skilled graduates. In turn, this drives the development of technologies needed to pursue the science. The nation has invested in the technology for millimetre-wave astronomy, building the first interferometer in our hemisphere. This equipm ....Water vapour radiometers for millimetre-wave phase correction for the Australia Telescope. Australia has a tradition of excellence in astronomy. Inspired by wonder about the cosmos, it stimulates public interest in science, so leading to the training of highly skilled graduates. In turn, this drives the development of technologies needed to pursue the science. The nation has invested in the technology for millimetre-wave astronomy, building the first interferometer in our hemisphere. This equipment will capitalise on this investment, extending the capabilities of the Australia Telescope to maintain it as a front line instrument, attracting the best scientists here to use it. This will help nurture a vigorous radio-science community, one able to actively participate in the billion-dollar investment being made internationally in the field.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0211588
Funder
Australian Research Council
Funding Amount
$120,000.00
Summary
The Classroom Learning Laboratory. A facility is proposed to support the collection, configuration, storage and analysis of data (particularly video data) related to learning and teaching in classrooms. The Co-Applicants currently direct major projects at all levels of institutionalised education from early-years to tertiary, particularly in mathematics and technology education. The facility will provide the infrastructure for several large-scale projects involving many researchers and in the l ....The Classroom Learning Laboratory. A facility is proposed to support the collection, configuration, storage and analysis of data (particularly video data) related to learning and teaching in classrooms. The Co-Applicants currently direct major projects at all levels of institutionalised education from early-years to tertiary, particularly in mathematics and technology education. The facility will provide the infrastructure for several large-scale projects involving many researchers and in the long-term has the potential to catalyse new activity by educational researchers throughout Australia and significant overseas collaborative involvement. The proposed facility addresses a growing need locally, nationally, and internationally, offering both data storage and efficient access for analysis.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560685
Funder
Australian Research Council
Funding Amount
$451,000.00
Summary
Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. Th ....Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. The bioelectrochemical imaging facility will be unique in Australia and establish an important cross-disciplinary approach within the international community.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882866
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
MALDI Imaging and Protein Analysis Facility for WA. Mass spectrometry as a tool for analytical research can be coupled to imaging of tissues to provide an important bridge between biochemical, cell biology and physiological sciences. These are competitive research areas that need the latest in speed, accuracy and sensitivity. Strategic placement of such infrastructure in locations of research strength is vital to allow hand-on use that promotes excellence, innovation and creative exploration of ....MALDI Imaging and Protein Analysis Facility for WA. Mass spectrometry as a tool for analytical research can be coupled to imaging of tissues to provide an important bridge between biochemical, cell biology and physiological sciences. These are competitive research areas that need the latest in speed, accuracy and sensitivity. Strategic placement of such infrastructure in locations of research strength is vital to allow hand-on use that promotes excellence, innovation and creative exploration of the limits of such tools to answer pressing questions in biology and chemistry. WA students and researchers will gain new opportunities in an arena of MALDI imaging in biological research and intact protein analysis for structural studies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237664
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT- ....High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT-ICR-MS will provide key structural information on a wide range of synthetic and natural chemical substances, including sequence (e.g. peptides) and fragmentation patterns, while the MALDI-TOF instrument will be used primarily for high through-put proteomic analyses.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775602
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
A ground station for the NANTEN2 sub-millimetre wave telescope. Australia has a tradition of excellence in astronomy. Inspired by our natural wonder about the cosmos, it helps stimulate public interest in science, so leading to the training of highly skilled graduates. This in turn drives development of technologies needed to pursue the science. The nation has invested in technology for millimetre-wave astronomy, building the first interferometer in our hemisphere. We aim to capitalise on this i ....A ground station for the NANTEN2 sub-millimetre wave telescope. Australia has a tradition of excellence in astronomy. Inspired by our natural wonder about the cosmos, it helps stimulate public interest in science, so leading to the training of highly skilled graduates. This in turn drives development of technologies needed to pursue the science. The nation has invested in technology for millimetre-wave astronomy, building the first interferometer in our hemisphere. We aim to capitalise on this investment, leveraging it to access a frontline facility under construction on the Atacama plateau in Chile. This will help nurture a vigorous radio-science community, one able to actively participate in the billion-dollar investment being made by the international community in astronomical facilities there.Read moreRead less