The Role Of Presenilin In Metal Homeostasis And Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$86,335.00
Summary
Presenilin, a protein involved in Alzheimer’s disease (AD), may regulate copper and zinc levels. Copper and zinc are essential nutrients however a deficiency or excess can cause disease. Promising metal-altering AD drugs, are in various stages of clinical trial. I aim to characterize the interaction of Presenilin and metals using both mouse and cultured human cell models that are deficient in Presenilin. Understanding this interaction should lead to better drug design and treatment of AD.
The Role Of Transcriptional Co-activators And Co-repressors During Embryonic Development
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
Every creature starts out as a single fertilized egg. The genome directs the embryonic development of the egg by regulating the expression of genes each of which must be turned on or off at the correct time and place. This essential balance between the activation or repression of genes is controlled by groups of proteins, including ‘transcriptional co-activators’ and ‘repressors’. This project aims to better understand the role of these proteins during embryonic development.
Randomised Controlled Trial Of A Sleep Intervention To Improve Child Behaviour, Quality Of Life And Learning
Funder
National Health and Medical Research Council
Funding Amount
$57,760.00
Summary
Nearly 20% of Australian parents report a problem with their preschool child's sleep. Child sleep problems are associated with an increased risk of child behaviour problems, poorer quality of life, and likelihood of a child being diagnosed with ADHD. We want to know if an education program for parents of prep children can reduce child sleep problems. It may represent a feasible way of reducing behaviour problems, improving quality of life and academic performance in these crucial years.