Signalling Pathways In Antibody-Mediated Renal Injury
Funder
National Health and Medical Research Council
Funding Amount
$113,296.00
Summary
Many types of kidney disease are induced by antibody binding to the kidney which initiates a damaging response by cells of the immune system. Current therapies for such diseases rely upon toxic immunosuppressive drugs. This project will examine one specific mechanism by which immune cells are activated by antibody to cause injury in human and experimental renal injury. These studies will determine whether this specific mechanism is a suitable target for developing new therapeutic drugs.
Identification Of Mechanisms By Which Mesenchymal Stromal Cells Ameliorate Renal Ischaemia Reperfusion Injury
Funder
National Health and Medical Research Council
Funding Amount
$104,985.00
Summary
Acute kidney injury (AKI) is a common clinical entity which is associated with an increased risk of death and chronic kidney disease. Infusing adult mesenchymal stromal cells (cells which usually reside in the bone marrow but migrate to sites of inflammation or injury) has been shown to be beneficial in animal models of AKI, but it is not known how they have this effect. This project is designed to investigate the mechanism of action of mesenchymal stromal cells in AKI.