Therapeutic Blockade Of Complement Inducing Inflammatory Injury In Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$133,181.00
Summary
ANCA associated vasculitis is an inflammatory disease involving the kidney filters which is a major cause of chronic kidney failure. Current drugs to treat it are toxic. Less toxic treatments are required. In this study we will explore the potential for new treatments targeting complement (a normal blood protein involved in inflammation) to attenuate this disease in mice. We hope to define the role of complement in this disease and the benefits of inhibiting it before we use it in humans.
Through this project, I will determine how diet and physical activity can improve the health and quality of life of people suffering from chronic kidney disease. I will also assess whether lifestyle interventions have the potential to prevent chronic kidney disease. My results will directly impact the lives of people with kidney disease and could lead to public health interventions to prevent kidney disease.
Chronic Kidney Diseases (CKDs) present serious morbidity and mortality in our society. Kidney scarring is the final manifestation of many types of kidney diseases. Recent evidence showed that a reduced ability to generate energy during injuries leads to kidney scarring. My study is looking at how the specific changes in kidney energy production can lead to kidney scarring. The findings of my study can have potential to prevent kidney scarring and change the course of kidney diseases.
Vitamin D And Chronic Kidney Disease: The Effects On Mineral Metabolism, Vascular Calcification And Transplant Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$103,582.00
Summary
Kidney disease is a major health issue in the community. Vitamin D deficiency has been associated with an increased burden of cardiovascular disease and mortality in these patients. Vitamin D also has been shown to have a significant role in modulating our immune system. This study aims to assess the potential of vitamin D therapy to reduce the burden of cardiovascular disease and its effects on the immune function of renal transplant recipients in the laboratory and clinical setting.
Antigen-specific Regulatory T Cells And HLA Associations In Autoimmune Renal Disease
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Glomerulonephritis (GN), a common cause of kidney failure, usually results from an immune system attack on the kidneys. Current treatments suppress the whole immune system, making patients vulnerable to infection. We aim to harness the body’s protective immune cells (Tregs) as a potential GN treatment. Using mice genetically programmed to mimic a human GN, we will test if specifically targeted Tregs protect mice from disease. We will also test how they affect blood samples from humans with GN.
The Effect Of Renal Transplantation And Extended Hours Haemodialysis On Cardiac MRI And Biomarkers.
Funder
National Health and Medical Research Council
Funding Amount
$107,750.00
Summary
Patients with chronic kidney disease (CKD) are at increased risk for cardiovascular disease (CVD). Asymptomatic patients demonstrate changes in cardiac imaging and elevation of cardiac biomarkers which predict outcome. This study will investigate serial cardiac imaging and cardiac biomarkers in patients undergoing live donor renal transplantation and extended hours haemodialysis. Results will enhance our understanding of cardiovascular disease in CKD leading to improved patient outcomes.
Long Term Sequelae Of Acute Kidney Injury: Identifying The Optimal Model Of Care And Intervention To Enhance Patient Outcome
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Acute kidney injury (AKI) is associated with significant morbidity, mortality and health care costs. It is increasingly recognised as a key driver of progressive kidney disease, and no intervention has been shown to improve the long-term outcome of AKI survivors. This project identifies risk factors for chronic kidney disease, dialysis dependence and death after an episode of AKI, and examines the feasibility, efficacy, and cost-effectiveness of early nephrology review in high risk individuals.
Cell Type Specific Mechanisms Of Mineralocorticoid Mediated Renal Injury In Glomerulonephritis And Diabetic Nephropathy
Funder
National Health and Medical Research Council
Funding Amount
$103,582.00
Summary
Mineralocorticoid exists normally in the human body to maintain fluid and salt balance. However, it is also implicated in diseases affecting the heart and the kidneys. My research aims to further our understanding on how mineralocorticoids contribute to kidney disease, and in particular, to investigate the role of specific kidney cells on mediating kidney injury. Ultimately this research may facilitate development of treatments allowing cell specific blockade of mineralocorticoids, which may red ....Mineralocorticoid exists normally in the human body to maintain fluid and salt balance. However, it is also implicated in diseases affecting the heart and the kidneys. My research aims to further our understanding on how mineralocorticoids contribute to kidney disease, and in particular, to investigate the role of specific kidney cells on mediating kidney injury. Ultimately this research may facilitate development of treatments allowing cell specific blockade of mineralocorticoids, which may reduce kidney diseases such as diabetic nephropathy.Read moreRead less
Musculoskeletal Strength In End Stage Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$109,358.00
Summary
People with advanced kidney disease have poorer musculoskeletal health leading to reduced quality of life. This project will examine the associations of musculoskeletal health and neuropathy with immediate and long term clinical outcomes.
Chronic Kidney Disease: Natural History Of Disease, Cost And Quality Of Life
Funder
National Health and Medical Research Council
Funding Amount
$72,281.00
Summary
Chronic kidney disease (CKD) is present in 12% of Australians aged over 25. CKD is associated with poor health outcomes including cardiovascular disease and progression to End Stage Kidney Disease. Many questions about CKD remain. My research aims to increase our understanding of the natural history of CKD in the Australian population, with focus on outcomes of CKD progression, cardiovascular and all-cause mortality, quality of life, and costs to society.