Developing And Implementing Proven Treatments And Systems Of Care In Stroke
Funder
National Health and Medical Research Council
Funding Amount
$873,684.00
Summary
This fellowship will allow me to continue undertaking large-scale, multicentre, national and international, randomised controlled trials and population-based epidemiological studies focussed on the prevention and managment of acute stroke and other aspects of cardiovascular disease related to ageing populations. Much of my research is focussed on research and health policy of populations in Asia, particularly China, where i have had a sustained program of collaborative research over 10 years.
Associate Professor Kate Denton is an internationally recognised cardiovascular researcher. A focus of Dr Denton’s research is to find out why women do not respond to current treatments as well as men, and how factors in pregnancy (nutrition, stress, alcohol) drive the development of cardiovascular disease in offspring. Dr Denton is also leading research to understand why a new high blood pressure treatment (blocking nerves to the kidney) is proving more effective than expected.
Ion channels are molecular pores of excitable membranes facilitating passage of ions and organic solutes across cellular membranes. An ever-increasing number of human and animal diseases result from malfunctioning ion channels making them to important therapeutic targets, which are modulated by a range of currently prescribed drugs. In the recent years the scientific and medical community has become increasingly aware of the role that mechanosensitive ion channels play in pathology of diseases i ....Ion channels are molecular pores of excitable membranes facilitating passage of ions and organic solutes across cellular membranes. An ever-increasing number of human and animal diseases result from malfunctioning ion channels making them to important therapeutic targets, which are modulated by a range of currently prescribed drugs. In the recent years the scientific and medical community has become increasingly aware of the role that mechanosensitive ion channels play in pathology of diseases including cardiac hyperthrophy and arrhythmias.Read moreRead less
Heart failure (HF) describes where the heart cannot pump adequately to meet the bodyÍs needs. Mortality remains high; therefore, there is an urgent need for new treatment approaches. The present grant aims to: (1) evaluate treatments for patients at high-risk for future development of HF (2) examine the ability to safely withdraw unnecessary HF drugs (3) focus on the effect of HF on the kidney via novel treatment strategies (4) examine the emerging role of cancer drugs in development of HF.
Prof Trevor Mori has held an NH&MRC Research Fellowship during 2008-2012. This grant will enable him to continue his research program into 2013-2017. Prof Mori is a biomedical research scientist. His research examines the role of diet and lifestyle on risk factors for cardiovascular disease. He also leads the cardiometabolic team examining risk factors in the Western Australian Pregnancy (Raine) Study.
Identifying And Developing Novel Therapeutic Approaches For Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$638,517.00
Summary
Increasing rates of obesity, diabetes, and an ageing population increase the risk of heart disease & complications including heart failure (HF), atrial fibrillation (AF), and diabetic heart disease. There is a clinical need for i) improved therapies for patients with HF, AF, and diabetic heart, and ii) biomarkers which more effectively recognise people at risk of heart disease, to prevent clinical events. My research program is designed to develop novel therapies and identify new biomarkers.
Reducing Disparities In Heart Disease-Related Morbidity And Mortality: Optimising Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$826,854.00
Summary
Heart disease contributes to a large but potentially preventable burden of death and disability. This burden is uneven with particularly vulnerable/at risk groups - including those living in regional areas and developing countries, Indigenous Australians and older patients with chronic heart disease. Prof. Simon Stewart will lead national/international collaborations to undertake innovative, multidisciplinary, prevention and disease management programs to reduce the impact and burden of heart di ....Heart disease contributes to a large but potentially preventable burden of death and disability. This burden is uneven with particularly vulnerable/at risk groups - including those living in regional areas and developing countries, Indigenous Australians and older patients with chronic heart disease. Prof. Simon Stewart will lead national/international collaborations to undertake innovative, multidisciplinary, prevention and disease management programs to reduce the impact and burden of heart disease in these vulnerable groups.Read moreRead less
Improving Outcomes In Heart Failure Through Basic, Clinical And Translational Research
Funder
National Health and Medical Research Council
Funding Amount
$951,005.00
Summary
Heart failure (HF) is a common, chronic cardiovascular condition characterised by a reduced capacity of the heart to function. Patients with HF have a poor quality of life and significantly reduced survival. My proposed programme of research will improve the understanding of heart failure (HF) and lead to better treatments.
Innovations In Prevention And Treatment Of Vascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
Novel clinical trials and related basic science research in the prevention and treatment of heart and blood vessel disease and diabetic complications will be undertaken, building on extensive collaborations and novel discoveries to date.
Integrated Basic And Clinical Cardiovascular Research For The Development Of Innovative Approaches To The Treatment Of Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$925,346.00
Summary
Heart failure (HF) is a common cardiovascular problem which causes disabling symptoms and reduces life expectancy. HF is the commonest cause or contributor to hospitalization in people over 65 years. For patients with advanced HF, survival is worse than that for aggresive cancers. At present, for patients with advanced HF and its complications, there are very few treatment options. Over the next 5 years I will conduct a comprehensive series of studies in animal models and in patients to develop ....Heart failure (HF) is a common cardiovascular problem which causes disabling symptoms and reduces life expectancy. HF is the commonest cause or contributor to hospitalization in people over 65 years. For patients with advanced HF, survival is worse than that for aggresive cancers. At present, for patients with advanced HF and its complications, there are very few treatment options. Over the next 5 years I will conduct a comprehensive series of studies in animal models and in patients to develop new treatment options.Read moreRead less