Systems Biology To Identify Molecular Targets For Vascular Disease Treatment (SysVasc), With A Focus On Atherosclerotic Plaque Instability
Funder
National Health and Medical Research Council
Funding Amount
$450,721.00
Summary
Heart attacks are caused by rupture of atherosclerotic deposits (plaques) in vessel walls, which results in clot formation ultimately causing vessel occlusion. In collaboration with strong European collaborators, we will use modern high-throughput technologies in a large patient cohort as well as in a newly generated mouse model to discover the causative proteins, genes and their regulators. This will allow identifying individuals at risk and developing novel therapies to prevent heart attacks.
Identifying The Epigenomic Fingerprint Of Coronary Heart Disease In Chinese Adults With Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$596,663.00
Summary
Once people get diabetes, even good glucose control may be insufficient to prevent its complications. Diabetes results in molecular imprinting contributing to an increased risk of heart disease. We believe it is possible to identify this imprinted risk by a sophisticated analysis of a standard blood sample. Validating this hypothesis will lead to new biomarkers to identify individuals at increased risk of heart attacks as well as new strategies for the prevention and treatment of heart disease.
A Smartphone-based Clinical Decision Support System For Primary Health Care Workers To Improve The Detection And Management Of Hypertension And Associated Cardiovascular Risk In Rural India.
Funder
National Health and Medical Research Council
Funding Amount
$954,505.00
Summary
We have found that around one in four adults in rural India have hypertension and a minority of these receive best practice care. Current health system infrastructure is grossly under-resourced to address this. We aim to improve hypertension management by strengthening primary health care workforce capacity through use of a smartphone based clinical decision support system that is integrated with existing health structures. This will be evaluated in a trial involving 45 villages in rural Andhra ....We have found that around one in four adults in rural India have hypertension and a minority of these receive best practice care. Current health system infrastructure is grossly under-resourced to address this. We aim to improve hypertension management by strengthening primary health care workforce capacity through use of a smartphone based clinical decision support system that is integrated with existing health structures. This will be evaluated in a trial involving 45 villages in rural Andhra Pradesh.Read moreRead less
Randomised Controlled Trial Of Early Use Of A Simplified Treatment Regimen Incorporating A Half-dose, Three-in-one Blood Pressure Lowering Pill Vs. Usual Care For Improving Hypertension Control In India.
Funder
National Health and Medical Research Council
Funding Amount
$1,095,201.00
Summary
Hypertension affects a large proportion of the Indian population. Effective medications exist to lower blood pressure (BP) and the adverse effects of hypertension. However, complex medication regimes and the need to take multiple drugs can affect patient adherence to drugs, making it difficult to achieve good BP control. This research will investigate whether use of a simplified treatment protocol including a three-in-one BP lowering pill can improve BP control in Indians with hypertension.