Discovery Early Career Researcher Award - Grant ID: DE230100206
Funder
Australian Research Council
Funding Amount
$423,154.00
Summary
Pain: Open to interpretation? This project aims to determine how pain interpretation drives pain experience, using rigorous state-of-the-art lab research. This project expects to generate new knowledge about the psychological mechanisms maintaining pain experience and avoidance behaviour, using novel techniques to measure interpretation of pain sensations. Expected outcomes include the development of an evidence-based psychological model of pain interpretation, enhanced capacity to build interna ....Pain: Open to interpretation? This project aims to determine how pain interpretation drives pain experience, using rigorous state-of-the-art lab research. This project expects to generate new knowledge about the psychological mechanisms maintaining pain experience and avoidance behaviour, using novel techniques to measure interpretation of pain sensations. Expected outcomes include the development of an evidence-based psychological model of pain interpretation, enhanced capacity to build international collaborations, and ecologically valid methods for measuring pain interpretation. This research forms a solid platform for further translational research, to build novel, scalable interventions to improve outcomes for the one in five Australians living with chronic pain.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101962
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Functional epigenomics interrogation of DNA methylation dynamics during vertebrate development and evolution. DNA methylation (mC) is an epigenetic signal essential for the maintenance of correct gene expression patterns. To investigate the causal relationships between mC and transcription during vertebrate embryonic development and evolution, this project will perform high-resolution mC profiling at different stages of teleost, amphibian and mammalian development. Highly conserved and syntenic, ....Functional epigenomics interrogation of DNA methylation dynamics during vertebrate development and evolution. DNA methylation (mC) is an epigenetic signal essential for the maintenance of correct gene expression patterns. To investigate the causal relationships between mC and transcription during vertebrate embryonic development and evolution, this project will perform high-resolution mC profiling at different stages of teleost, amphibian and mammalian development. Highly conserved and syntenic, methylated sequences will then be used as baits in proteomics screens to identify novel 5mC 'readers'. The generation of genomic profiles of mC 'readers' and their integration with developmental mC maps will reveal transient epigenome dynamics during vertebrate embryogenesis and provide new insights into the conservation of these crucial developmental mechanisms.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100329
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Photocatalytic reduction of carbon dioxide with water into hydrocarbon fuels and chemicals. This project aims to develop a highly efficient photocatalytic process for converting CO2 into hydrocarbon fuels and high value-added chemicals. This new technology can reduce CO2 concentrations in the environment and provide a feasible mean to produce non-fossil fuels and industrial chemicals that society has to depend upon.
Discovery Early Career Researcher Award - Grant ID: DE170101081
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Adaptive value-flow analysis to improve code reliability and security. This project aims to develop client-driven adaptive value-flow analysis to detect software bugs in system software written in the C/C++ programme language. Static analysis tools for automated code inspections can benefit software developers, but are imprecise, inefficient and not user-friendly for analysing real-world industrial-sized software. The project will investigate static, dynamic and user-guided value-flow analysis t ....Adaptive value-flow analysis to improve code reliability and security. This project aims to develop client-driven adaptive value-flow analysis to detect software bugs in system software written in the C/C++ programme language. Static analysis tools for automated code inspections can benefit software developers, but are imprecise, inefficient and not user-friendly for analysing real-world industrial-sized software. The project will investigate static, dynamic and user-guided value-flow analysis to efficiently and precisely analyse large-scale programs according to clients’ needs, thereby allowing compilers to generate safe, reliable and secure code. This project is expected to advance value-flow analysis for industrial-sized software, improve software reliability and security, and benefit Australian software systems and industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101521
Funder
Australian Research Council
Funding Amount
$349,699.00
Summary
The development, ecology and evolution of alternative phenotypes. Diseases, crops, livestock, and even some natural resources evolve, therefore comprehending evolutionary processes and their implications for humans is paramount. A paradigm shift in evolutionary theory was the realisation that genes are not the whole story, and that plasticity to the environment is vital for evolution. This highlights the importance of environmentally sensitive traits, such as conditional alternative phenotypes, ....The development, ecology and evolution of alternative phenotypes. Diseases, crops, livestock, and even some natural resources evolve, therefore comprehending evolutionary processes and their implications for humans is paramount. A paradigm shift in evolutionary theory was the realisation that genes are not the whole story, and that plasticity to the environment is vital for evolution. This highlights the importance of environmentally sensitive traits, such as conditional alternative phenotypes, where a genome can produce completely different morphologies in different environments. This project aims to investigate the development, evolutionary potential, and ecology of alternative phenotypes, contributing to our ability to understand and manage the most important of biological processes, evolution.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100216
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Emotions, language and culture in Arnhem Land (Katherine region). This project aims to increase our understanding of emotional language and cultural practices about emotions among Indigenous Australian groups. Emotion is a fundamental human experience, yet different languages provide very different ways of talking about it. What are the consequences of this? Are these differences culturally constrained? Might differences in the grammar of a language influence the way its speakers express emotion ....Emotions, language and culture in Arnhem Land (Katherine region). This project aims to increase our understanding of emotional language and cultural practices about emotions among Indigenous Australian groups. Emotion is a fundamental human experience, yet different languages provide very different ways of talking about it. What are the consequences of this? Are these differences culturally constrained? Might differences in the grammar of a language influence the way its speakers express emotions, or even the way they experience emotions? This project seeks to describe and compare the way emotions are expressed in five Aboriginal languages of Arnhem Land. Four of these languages are endangered and the project will also provide the urgent documentation needed to preserve them.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100517
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Organocatalysis: A New Horizon for Synthesis of Organic Structures. The current technologies to synthesise organic substances, an important part of human life, often involve the use of excess amounts of reagents or precious and toxic metal catalysts, which incur high production costs and severe environmental impact. This project aims to use organocatalysis, chemical processes catalysed by stable, small, easily accessible, non-metallic organic compounds, to find a solution for these issues. Novel ....Organocatalysis: A New Horizon for Synthesis of Organic Structures. The current technologies to synthesise organic substances, an important part of human life, often involve the use of excess amounts of reagents or precious and toxic metal catalysts, which incur high production costs and severe environmental impact. This project aims to use organocatalysis, chemical processes catalysed by stable, small, easily accessible, non-metallic organic compounds, to find a solution for these issues. Novel organocatalytic methods will be designed and developed in order to promote environmentally friendly, highly efficient and selective chemical procedures for low cost production of laboratory organic substances and application in the industrial synthesis of potential agrochemicals and medicinal agents.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100256
Funder
Australian Research Council
Funding Amount
$415,283.00
Summary
Extracting the hidden structure of glass from particle vibrations. Predicting the rigid behaviour of glass from its disordered, amorphous atomic structure remains a challenge in materials science. This project aims to define an innovative measure of structure based on how constrained each particle is, which can be quantified by measuring the particles’ vibrations. Using this new measure of structure, this project expects to link the microscopic structure of glass to its macroscopic properties v ....Extracting the hidden structure of glass from particle vibrations. Predicting the rigid behaviour of glass from its disordered, amorphous atomic structure remains a challenge in materials science. This project aims to define an innovative measure of structure based on how constrained each particle is, which can be quantified by measuring the particles’ vibrations. Using this new measure of structure, this project expects to link the microscopic structure of glass to its macroscopic properties via computer simulations. Expected outcomes of this project include a new methodology for characterising amorphous materials and an improved understanding of the nature of glass. This should provide significant benefits, such as an increased ability to rationally design amorphous materials with desired properties.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100475
Funder
Australian Research Council
Funding Amount
$448,008.00
Summary
Exploring Business Approaches to the Modern Slavery - Climate Change Nexus. This project aims to generate awareness and knowledge about the modern slavery – climate change nexus. Businesses can be linked to modern slavery and climate change through their operations and supply chains, and play a major role in mitigating these critical issues. The project will: (1) reveal the extent to which businesses recognise and address modern slavery and climate change as related issues; (2) develop an eviden ....Exploring Business Approaches to the Modern Slavery - Climate Change Nexus. This project aims to generate awareness and knowledge about the modern slavery – climate change nexus. Businesses can be linked to modern slavery and climate change through their operations and supply chains, and play a major role in mitigating these critical issues. The project will: (1) reveal the extent to which businesses recognise and address modern slavery and climate change as related issues; (2) develop an evidence-base detailing what constitutes meaningful and holistic business approaches and disclosures; (3) assess how market-based mechanisms are used to incentivise action and hold businesses to account. The outcomes will advance business efforts and accountability in relation to these problems and benefit impacted communities.
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Discovery Early Career Researcher Award - Grant ID: DE160100732
Funder
Australian Research Council
Funding Amount
$359,544.00
Summary
Electrostatic Catalysis: guiding reactive interfaces using electric fields. This project seeks to gain quantitative understanding of the role of electrostatics over chemical processes. Chemical transformations of organic compounds at interfaces underpin some of the most important processes, from the production of fine chemicals for pharmaceuticals to assisting bio-degradation of pollutants in clean technologies. Recent computational studies suggest that by applying oriented electric fields at in ....Electrostatic Catalysis: guiding reactive interfaces using electric fields. This project seeks to gain quantitative understanding of the role of electrostatics over chemical processes. Chemical transformations of organic compounds at interfaces underpin some of the most important processes, from the production of fine chemicals for pharmaceuticals to assisting bio-degradation of pollutants in clean technologies. Recent computational studies suggest that by applying oriented electric fields at interfaces, the rate and the selectivity of chemical processes can be altered at will. The project intends to test these theoretical findings. The knowledge generated by this research may translate into new technologies for the fine-chemical and biotechnology industries.Read moreRead less