Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science an ....Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science and technology infrastructure within Australia, taking it into original and exciting directions, contribute to training young Australian scientists and students, as well as enhance Australia's competitive position in the field of nanobiotechnology.Read moreRead less
Nanostructured Carbon Electrodes. The development of higher capacity energy storage devices is critical to the efficient use of energy. The fundamental knowledge gained in this project will enable the production of the next generation advanced electrode materials for this purpose and hence provide many new commercial opportunities for Australian industry. The project brings together world leaders in their own fields to address a highly multidisciplinary area of research and will provide an excel ....Nanostructured Carbon Electrodes. The development of higher capacity energy storage devices is critical to the efficient use of energy. The fundamental knowledge gained in this project will enable the production of the next generation advanced electrode materials for this purpose and hence provide many new commercial opportunities for Australian industry. The project brings together world leaders in their own fields to address a highly multidisciplinary area of research and will provide an excellent training for PhD students and post doctoral Research Fellows, enabling them to work in and contribute to the development of new nanotechnology industries in Australia.Read moreRead less
Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for l ....Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for liposomes. This provides a significant PhD training opportunity and brings an international focus to the development of planar patch-clamp electrophysiology in Australia. The project has significant commercial potential by developing both the planar patch-clamp electrophysiology techniques for liposomes and producing a novel biomimetic mechanosensitive biosensor.Read moreRead less
Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities ....Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities to address current limitations in understanding the stability of magnetic nanoparticles in biological fluids. The Australian partners will play a leading role in commercializing new applications for functionalized magnetic nanoparticles. The project will provide an excellent multidisciplinary research environment and training for early career researchers.Read moreRead less
Quantification of airborne engineered nanoparticles: developing a scientific framework to inform their regulation and control. Despite the presence of airborne engineered nanoparticles in many commercial/research facilities, there are no established methods for their detection/characterisation. This work aims to develop a foundation for the quantitative assessment of airborne engineered nanoparticles, which is critical for controlling exposure and minimising health risks.
Development of advanced lithium ion battery and battery management system for electric /hybrid electric vehicle applications. This project represents a significant scientific and economic development for Australia as it aims to create advanced, high performing, energy storage devices with a focus on safety, that will provide enormous benefits for the environment. An added advantage will be the establishment of local and national expertise in the area of electrochemical energy storage systems, th ....Development of advanced lithium ion battery and battery management system for electric /hybrid electric vehicle applications. This project represents a significant scientific and economic development for Australia as it aims to create advanced, high performing, energy storage devices with a focus on safety, that will provide enormous benefits for the environment. An added advantage will be the establishment of local and national expertise in the area of electrochemical energy storage systems, that will place Australia at the forefront of lithium ion battery research and development. Flow-on benefits will also be created for Australian organizations involved in the manufacturing of electric vehicles and portable devices.Read moreRead less
Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation o ....Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation of nanomaterials with antibodies. This project has the potential to rapidly improve the ligation process between synthetic nanomaterials and biologics, leading to more efficient synthesis of targeted diagnostics. This would provide a significant commercial advantage for any nanomaterials developed for the field, and specifically for this project, expedite translation of MIL38.Read moreRead less
The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery. This project provides a unique opportunity to develop an Australian-invented technology in particle engineering, enabling it to enter the international pharmaceutical market. This will enhance the growth of Australia's pharmaceutical research and development, and benefit the Australian pharmaceutical industry. The outcome will also contribute to improvements in the heal ....The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery. This project provides a unique opportunity to develop an Australian-invented technology in particle engineering, enabling it to enter the international pharmaceutical market. This will enhance the growth of Australia's pharmaceutical research and development, and benefit the Australian pharmaceutical industry. The outcome will also contribute to improvements in the health and well-being of Australians. The research falls within the Designated National Research Priority of Frontier Technologies for Building and Transforming Australian Industries.Read moreRead less
Development of dense gas technology platforms for the formulation of oral vaccines. This project will aim to develop a technology platform that enables the formulation of vaccines that can be delivered orally and this research has the potential to radically change existing vaccination regimens. The availability of needle-free vaccination also has potential for considerable societal and economic impact in developing countries.
Novel methods for enhancing room temperature figure of merit of thermoelectric/thermionic materials for refrigeration applications. With global warming and an increased awareness of climate change, devices such as thermoelectric modules can be part of the solution, particularly if their relative power and efficiency can be increased. The aim of this project is to bring together theoreticians, experimentalists, materials scientists, and industrial partners with complementary expertise to develop ....Novel methods for enhancing room temperature figure of merit of thermoelectric/thermionic materials for refrigeration applications. With global warming and an increased awareness of climate change, devices such as thermoelectric modules can be part of the solution, particularly if their relative power and efficiency can be increased. The aim of this project is to bring together theoreticians, experimentalists, materials scientists, and industrial partners with complementary expertise to develop new techniques and methods for fabricating novel thermoelectric/thermionic materials with high figure of merit, ZT, for solid state refrigeration applications. The success of the project will lead to a 3 to 5 fold increase in the market share of thermoelectric cooler and will have a significant impact on the Australian economy and reduce greenhouse emissions and global warming. Read moreRead less