Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100061
Funder
Australian Research Council
Funding Amount
$710,000.00
Summary
Extending frontiers of structural chemistry and biology through high resolution pulsed Electron Paramagnetic Resonance. Multifrequency high resolution pulsed Electron Paramagnetic Resonance (EPR) instrumentation will provide forefront technologies in identifying, characterising, quantifying and visualising free radicals and metal ions that are involved in fundamental chemical and biological processes in science and nature.
Breaching membrane barriers. This project will endeavour to develop novel molecular transporters to deliver macromolecules inside cells or microorganisms. Cell membranes are barriers to macromolecules. The ability to cross these barriers and deliver biological macromolecules into cells represents a major achievement with endless opportunities to modulate pathways and to introduce biomarkers, therapeutics and research tools. The project’s novel platform technology would be based on stable cyclic ....Breaching membrane barriers. This project will endeavour to develop novel molecular transporters to deliver macromolecules inside cells or microorganisms. Cell membranes are barriers to macromolecules. The ability to cross these barriers and deliver biological macromolecules into cells represents a major achievement with endless opportunities to modulate pathways and to introduce biomarkers, therapeutics and research tools. The project’s novel platform technology would be based on stable cyclic peptides to deliver genes, proteins, probes or biomarkers into distinct cell types that can monitor or modulate specific pathways and be translated into new knowledge and specific industrial applications.Read moreRead less
Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk ass ....Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk assessment. This is intended to be achieved by developing and validating high-throughput in vitro toxicity screening platforms for manufactured nanoparticles. The approach is based on advanced lab-on-a-chip microfluidic technologies. The predictive power of the platform will be refined and optimised via ex-vivo and in-vivo models.Read moreRead less
Examination of unique tear lipids and their role in the tear film's structure and function. The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is signi ....Examination of unique tear lipids and their role in the tear film's structure and function. The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is significant because the unique combination of skills including synthetic chemistry, mass spectrometry, lipidomics, biochemistry, biophysics which aim to result in a major shift in the understanding of this layer.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100129
Funder
Australian Research Council
Funding Amount
$249,000.00
Summary
Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution ma ....Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution mass spectrometer is fundamental to extend our research capabilities to new environmental contaminants and environmental exposure biomarkers, as well as consumption biomarkers of new illicit drugs and their metabolites. This instrument will fill an important gap in our capacity to link health/ecological risk to unknown chemicals and will allow interdisciplinary researchers to advance work in environmental toxicology, chemistry and forensics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100158
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
Small angle X-ray scattering facility for Queensland. This project aims to provide an advanced small angle X-ray scattering facility for the examination of versatile porous and nano-size sample types. Understanding the structure-function relationship is crucial for developing high-performance nanostructured materials in bio-applications, renewable energy, energy storage, and water treatment. The proposed facility will support the development of new functional materials for industry reform, mappi ....Small angle X-ray scattering facility for Queensland. This project aims to provide an advanced small angle X-ray scattering facility for the examination of versatile porous and nano-size sample types. Understanding the structure-function relationship is crucial for developing high-performance nanostructured materials in bio-applications, renewable energy, energy storage, and water treatment. The proposed facility will support the development of new functional materials for industry reform, mapping oil and gas reserves, developing innovative technologies for new energy resources, and gas deliverability. The project is strongly aligned with the Advanced Manufacturing Science and Research Priority by providing high-performance materials, and generating new technologies to support major industries in Queensland and Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100144
Funder
Australian Research Council
Funding Amount
$480,000.00
Summary
Advanced X-ray facility for structural elucidation and photocrystallography. This project aims to establish an advanced photocrystallography X-ray facility. Accurately determining molecular structure and understanding how molecules interact with light is important to design and optimise new materials. Normally, measurements to elucidate these properties have to be done separately, making structure-property correlations difficult. The facility will allow the creation of new materials with applica ....Advanced X-ray facility for structural elucidation and photocrystallography. This project aims to establish an advanced photocrystallography X-ray facility. Accurately determining molecular structure and understanding how molecules interact with light is important to design and optimise new materials. Normally, measurements to elucidate these properties have to be done separately, making structure-property correlations difficult. The facility will allow the creation of new materials with application in pharmaceuticals, separation science, organic optoelectronics and magnetic materials. The facility will build capacity in X-ray techniques, create collaborations and provide a unique training ground for students and Early Career Researchers. The advances in materials innovation will strengthen the future viability of Australian industries and manufacturing innovation.Read moreRead less
Heparan sulphate mimetics: Versatile tools for chemical biology. This project aims to develop chemical tools to study heparan sulphate-binding proteins. Heparan sulphate is a complex polysaccharide that is ubiquitously expressed on mammalian cells and interacts with proteins to mediate numerous biological and pathological functions. These interactions are poorly understood. This project will use homogeneous, structurally defined compounds to study heparan sulphate and its binding partners in bio ....Heparan sulphate mimetics: Versatile tools for chemical biology. This project aims to develop chemical tools to study heparan sulphate-binding proteins. Heparan sulphate is a complex polysaccharide that is ubiquitously expressed on mammalian cells and interacts with proteins to mediate numerous biological and pathological functions. These interactions are poorly understood. This project will use homogeneous, structurally defined compounds to study heparan sulphate and its binding partners in biology. This is expected to lead to a better, molecular-level understanding of these fundamental processes, and may have future applications in biotechnology and drug development.Read moreRead less
Two-dimensional graphitic carbon nitride heterostructures for solar hydrogen production. This project aims to develop a low cost and efficient photo-catalyst for splitting water into clean hydrogen fuel. Two-dimensional (2D) van der Waals hetero-structures (stacked 2D crystals) can modulate optical absorption, charge separation and hydrogen evolution activity better than a single 2D material and thus produce hydrogen more efficiently. The approach will build on recent success in controlling elec ....Two-dimensional graphitic carbon nitride heterostructures for solar hydrogen production. This project aims to develop a low cost and efficient photo-catalyst for splitting water into clean hydrogen fuel. Two-dimensional (2D) van der Waals hetero-structures (stacked 2D crystals) can modulate optical absorption, charge separation and hydrogen evolution activity better than a single 2D material and thus produce hydrogen more efficiently. The approach will build on recent success in controlling electron coupling at the hetero-interface. The materials and knowledge achieved from this project will advance the development of renewable energy technology, providing solutions to the global energy and environmental issues.Read moreRead less