Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100061
Funder
Australian Research Council
Funding Amount
$710,000.00
Summary
Extending frontiers of structural chemistry and biology through high resolution pulsed Electron Paramagnetic Resonance. Multifrequency high resolution pulsed Electron Paramagnetic Resonance (EPR) instrumentation will provide forefront technologies in identifying, characterising, quantifying and visualising free radicals and metal ions that are involved in fundamental chemical and biological processes in science and nature.
Breaching membrane barriers. This project will endeavour to develop novel molecular transporters to deliver macromolecules inside cells or microorganisms. Cell membranes are barriers to macromolecules. The ability to cross these barriers and deliver biological macromolecules into cells represents a major achievement with endless opportunities to modulate pathways and to introduce biomarkers, therapeutics and research tools. The project’s novel platform technology would be based on stable cyclic ....Breaching membrane barriers. This project will endeavour to develop novel molecular transporters to deliver macromolecules inside cells or microorganisms. Cell membranes are barriers to macromolecules. The ability to cross these barriers and deliver biological macromolecules into cells represents a major achievement with endless opportunities to modulate pathways and to introduce biomarkers, therapeutics and research tools. The project’s novel platform technology would be based on stable cyclic peptides to deliver genes, proteins, probes or biomarkers into distinct cell types that can monitor or modulate specific pathways and be translated into new knowledge and specific industrial applications.Read moreRead less
Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk ass ....Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk assessment. This is intended to be achieved by developing and validating high-throughput in vitro toxicity screening platforms for manufactured nanoparticles. The approach is based on advanced lab-on-a-chip microfluidic technologies. The predictive power of the platform will be refined and optimised via ex-vivo and in-vivo models.Read moreRead less
Examination of unique tear lipids and their role in the tear film's structure and function. The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is signi ....Examination of unique tear lipids and their role in the tear film's structure and function. The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is significant because the unique combination of skills including synthetic chemistry, mass spectrometry, lipidomics, biochemistry, biophysics which aim to result in a major shift in the understanding of this layer.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100129
Funder
Australian Research Council
Funding Amount
$249,000.00
Summary
Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution ma ....Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution mass spectrometer is fundamental to extend our research capabilities to new environmental contaminants and environmental exposure biomarkers, as well as consumption biomarkers of new illicit drugs and their metabolites. This instrument will fill an important gap in our capacity to link health/ecological risk to unknown chemicals and will allow interdisciplinary researchers to advance work in environmental toxicology, chemistry and forensics.Read moreRead less
ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the d ....ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the design of peptides and proteins for targeted scientific, agricultural, biotechnology, animal health and pharmaceutical applications. CIPPS will assemble leading researchers from diverse disciplines to create a sustainable national entity that will drive new Australian industries and train next generation researchers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100158
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
Small angle X-ray scattering facility for Queensland. This project aims to provide an advanced small angle X-ray scattering facility for the examination of versatile porous and nano-size sample types. Understanding the structure-function relationship is crucial for developing high-performance nanostructured materials in bio-applications, renewable energy, energy storage, and water treatment. The proposed facility will support the development of new functional materials for industry reform, mappi ....Small angle X-ray scattering facility for Queensland. This project aims to provide an advanced small angle X-ray scattering facility for the examination of versatile porous and nano-size sample types. Understanding the structure-function relationship is crucial for developing high-performance nanostructured materials in bio-applications, renewable energy, energy storage, and water treatment. The proposed facility will support the development of new functional materials for industry reform, mapping oil and gas reserves, developing innovative technologies for new energy resources, and gas deliverability. The project is strongly aligned with the Advanced Manufacturing Science and Research Priority by providing high-performance materials, and generating new technologies to support major industries in Queensland and Australia.Read moreRead less
Nanoscale electrochemical imaging of catalyst inks for water oxidation. This project aims to reduce the cost of current water splitting technology by making new catalysts from earth abundant materials that will ensure a sustainable technological solution for the storage of renewable energy. This technology is an excellent solution to storing energy from intermittent renewable energy sources such as solar as it generates hydrogen which is a clean fuel. Using new techniques that can image the cata ....Nanoscale electrochemical imaging of catalyst inks for water oxidation. This project aims to reduce the cost of current water splitting technology by making new catalysts from earth abundant materials that will ensure a sustainable technological solution for the storage of renewable energy. This technology is an excellent solution to storing energy from intermittent renewable energy sources such as solar as it generates hydrogen which is a clean fuel. Using new techniques that can image the catalyst at the nanoscale while it is operating is expected to provide the knowledge for developing the next generation of water splitting electrolysers that can be utilised by households and businesses for storing solar or wind energy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100144
Funder
Australian Research Council
Funding Amount
$480,000.00
Summary
Advanced X-ray facility for structural elucidation and photocrystallography. This project aims to establish an advanced photocrystallography X-ray facility. Accurately determining molecular structure and understanding how molecules interact with light is important to design and optimise new materials. Normally, measurements to elucidate these properties have to be done separately, making structure-property correlations difficult. The facility will allow the creation of new materials with applica ....Advanced X-ray facility for structural elucidation and photocrystallography. This project aims to establish an advanced photocrystallography X-ray facility. Accurately determining molecular structure and understanding how molecules interact with light is important to design and optimise new materials. Normally, measurements to elucidate these properties have to be done separately, making structure-property correlations difficult. The facility will allow the creation of new materials with application in pharmaceuticals, separation science, organic optoelectronics and magnetic materials. The facility will build capacity in X-ray techniques, create collaborations and provide a unique training ground for students and Early Career Researchers. The advances in materials innovation will strengthen the future viability of Australian industries and manufacturing innovation.Read moreRead less