Visualising molecular level detail in single cells and intact tissues. The goal of this project is to deliver a new toolkit for imaging cells at an unprecedented resolution and level of chemical detail. We will expand the capabilities of two existing, but complementary, methods: optical fluorescence microscopy with responsive probes and X-ray fluorescence imaging. Expected outcomes include improved techniques and benchmarks for visualising bacterial and mammalian cells; development of new molecu ....Visualising molecular level detail in single cells and intact tissues. The goal of this project is to deliver a new toolkit for imaging cells at an unprecedented resolution and level of chemical detail. We will expand the capabilities of two existing, but complementary, methods: optical fluorescence microscopy with responsive probes and X-ray fluorescence imaging. Expected outcomes include improved techniques and benchmarks for visualising bacterial and mammalian cells; development of new molecules for elucidating cellular chemistry; better utilisation of valuable synchrotron resources; and greater understanding of the strengths and limitations of current microscopy workflows. Results should benefit the biotechnology sector, and may lead to improved medical, diagnostic, and bioremediation capacity.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100129
Funder
Australian Research Council
Funding Amount
$249,000.00
Summary
Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution ma ....Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution mass spectrometer is fundamental to extend our research capabilities to new environmental contaminants and environmental exposure biomarkers, as well as consumption biomarkers of new illicit drugs and their metabolites. This instrument will fill an important gap in our capacity to link health/ecological risk to unknown chemicals and will allow interdisciplinary researchers to advance work in environmental toxicology, chemistry and forensics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100042
Funder
Australian Research Council
Funding Amount
$190,000.00
Summary
UV to mid-infrared fluorescence spectrometer for use in mineral analysis, radiation dosimetry, and laser materials characterisation. Ultraviolet to mid-infrared fluorescence spectrometer for use in mineral analysis, radiation dosimetry and laser materials characterisation: This project will provide equipment with a vast capability to collect ultraviolet to mid-infrared fluorescence with high temporal measurement accuracy, and highly flexible excitation (spectral and temporal). This will enhance ....UV to mid-infrared fluorescence spectrometer for use in mineral analysis, radiation dosimetry, and laser materials characterisation. Ultraviolet to mid-infrared fluorescence spectrometer for use in mineral analysis, radiation dosimetry and laser materials characterisation: This project will provide equipment with a vast capability to collect ultraviolet to mid-infrared fluorescence with high temporal measurement accuracy, and highly flexible excitation (spectral and temporal). This will enhance active research into new glasses and laser crystals, probing of defect states resulting from ionising radiation absorption in environmental and medical dosimetry materials, investigation of novel fluorescence techniques for mineral identification, through to improving chemical detection capability (for example, detection of explosives). The instrument comprises modules that enable excitation in the ultraviolet, visible, and infrared from a tunable laser system, and high-efficiency collection and processing of fluorescence spectra.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100060
Funder
Australian Research Council
Funding Amount
$563,390.00
Summary
Shared picosecond-laser facility. This project aims to extend the Shared Picosecond Laser Facility to include picosecond-pulse technology and to incorporate new consortium members. The Facility, shared among members at four universities and building on over 23 years of collaboration, continues to provide access to state-of-the-art lasers. The Facility will take advantage of its bulk purchasing power to negotiate significant discounts, extended warranties and maintenance contracts. The new lasers ....Shared picosecond-laser facility. This project aims to extend the Shared Picosecond Laser Facility to include picosecond-pulse technology and to incorporate new consortium members. The Facility, shared among members at four universities and building on over 23 years of collaboration, continues to provide access to state-of-the-art lasers. The Facility will take advantage of its bulk purchasing power to negotiate significant discounts, extended warranties and maintenance contracts. The new lasers will enable access to picosecond timescales and facilitate complex multi-laser experiments in a wide variety of projects including reaction dynamics, materials chemistry and photovoltaics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100153
Funder
Australian Research Council
Funding Amount
$497,264.00
Summary
Integrated In situ Characterisation Facilities for Energy Studies. This project aims to establish a new capability to reveal catalytic behaviour of materials under practical working conditions at multi-scale levels. Through in situ monitoring of surface, interface and structural properties of catalysts, this unique integrated facility will overcome current limitations due to a lack of understanding of reaction mechanism, by ex situ and/or individual in situ characterisations. This world-class fa ....Integrated In situ Characterisation Facilities for Energy Studies. This project aims to establish a new capability to reveal catalytic behaviour of materials under practical working conditions at multi-scale levels. Through in situ monitoring of surface, interface and structural properties of catalysts, this unique integrated facility will overcome current limitations due to a lack of understanding of reaction mechanism, by ex situ and/or individual in situ characterisations. This world-class facility will significantly advance a range of electrocatalysis, photocatalysis and battery applications for renewable energy-storage and clean-fuel generation. This will be Australia’s only platform; it will benefit a number of innovative research projects in energy, catalysis and environmental and materials science.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100093
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Shared laser facility. This shared laser facility will provide a pool of lasers to support the research of about 20 research groups and 30 PhD students.
Novel plastics using renewable signal chemistry to remove bacteria in water. This project plans to develop synthetic plastic surfaces that continuously generate nitric oxide to deter the formation of biofilms. Plastic surfaces exposed to aqueous environments rapidly become covered by a film of bacteria, which can cause infection. Trace levels of generated nitric oxide can combat this problem by breaking up existing bacterial biofilms. Current research has developed plastics that continuously gen ....Novel plastics using renewable signal chemistry to remove bacteria in water. This project plans to develop synthetic plastic surfaces that continuously generate nitric oxide to deter the formation of biofilms. Plastic surfaces exposed to aqueous environments rapidly become covered by a film of bacteria, which can cause infection. Trace levels of generated nitric oxide can combat this problem by breaking up existing bacterial biofilms. Current research has developed plastics that continuously generate nitric oxide, but not for extended periods of time. This project’s approach is significant because it avoids bacterial resistance to the nitric oxide treatment. Applications of this technology may include removing biofilms from environments such as water filtration devices and consumable medical surfaces.Read moreRead less
Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies. In order to understand the fundamentals of life processes, diseases, and their treatments, it is essential to probe fundamental changes in molecular processes in cells, tissues and whole organisms. Much of our understanding of these processes has involved the introduction of chemical probes for biospectroscopy, but these have inherent problems because the probe can often change the biochemistry that is being probed. This projec ....Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies. In order to understand the fundamentals of life processes, diseases, and their treatments, it is essential to probe fundamental changes in molecular processes in cells, tissues and whole organisms. Much of our understanding of these processes has involved the introduction of chemical probes for biospectroscopy, but these have inherent problems because the probe can often change the biochemistry that is being probed. This project will push the boundaries of a variety of micro and nano "probe-free" microscopies to provide fundamental insights into these life processes, which could ultimately lead to improvements in the diagnosis, prevention and treatment of diseases.Read moreRead less
ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less