Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100131
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Biomaterials characterisation facility. The convergence of nanotechnology and biotechnology offers new opportunities to prepare nanoengineered materials for applications in biomedicine. The Biomaterials Characterisation Facility will provide equipment to characterise such nanoengineered materials to underpin advances in therapeutic drug delivery and tissue engineering.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100001
Funder
Australian Research Council
Funding Amount
$345,475.00
Summary
Pushing the limits of fluorescence microscopy with adaptive optics. This project aims to establish an adaptive optics, super-resolution optical microscopy facility to image cellular events with the highest possible spatial resolution, in a whole cell or tissue context. Sophisticated computer-controlled deformable mirrors will be used to correct the way light is distorted as it passes through specimens, thereby overcoming aberrations found in thick and complex samples. This adaptive optics system ....Pushing the limits of fluorescence microscopy with adaptive optics. This project aims to establish an adaptive optics, super-resolution optical microscopy facility to image cellular events with the highest possible spatial resolution, in a whole cell or tissue context. Sophisticated computer-controlled deformable mirrors will be used to correct the way light is distorted as it passes through specimens, thereby overcoming aberrations found in thick and complex samples. This adaptive optics system will enable researchers to study complex behaviour of biological specimens, at the optical resolution limit in plant and animal tissues, leading to basic biology and biotechnology outcomes in biofuels, biomaterials and biomedicines.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.
Discovery Early Career Researcher Award - Grant ID: DE150100652
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Regulation of organ size and stem cell hierarchy in the developing kidney. Transient stem/progenitor cell populations play essential roles in establishing organ systems. The balance between self-renewal and differentiation in the nephron progenitor population plays a major, but poorly understood, role in regulating kidney development. Factors produced by undifferentiated progenitors promote organ expansion, whereas differentiation of these cells builds functional capacity. What is not clear is h ....Regulation of organ size and stem cell hierarchy in the developing kidney. Transient stem/progenitor cell populations play essential roles in establishing organ systems. The balance between self-renewal and differentiation in the nephron progenitor population plays a major, but poorly understood, role in regulating kidney development. Factors produced by undifferentiated progenitors promote organ expansion, whereas differentiation of these cells builds functional capacity. What is not clear is how the balance between self-renewal and differentiation is regulated in these cells, nor how the control of this fate decision impacts on optimal organ development. This project aims to dissect the molecular identity, regulation, and influence of this stem cell population on kidney development.Read moreRead less
The cellular basis of branching morphogenesis during kidney development. This project aims to study the process of branching morphogenesis which drives the development of the kidney. Previous studies group have demonstrated, in general terms, how branching progresses during gestation. However, little is known about the fundamental cellular events which trigger or characterise this basic developmental process. This project expects to provide deep insights into the cellular basis of tissue and org ....The cellular basis of branching morphogenesis during kidney development. This project aims to study the process of branching morphogenesis which drives the development of the kidney. Previous studies group have demonstrated, in general terms, how branching progresses during gestation. However, little is known about the fundamental cellular events which trigger or characterise this basic developmental process. This project expects to provide deep insights into the cellular basis of tissue and organ development. In studying this process the project should provide critical insights into how cells act, individually and collectively, to build tissues.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100310
Funder
Australian Research Council
Funding Amount
$360,533.00
Summary
Atmospheric trace gases: Fuelling the dormant microbial majority. This project aims to determine the physiological roles and ecological significance of hydrogen, methane and carbon monoxide scavenging. Bacteria adapt to adverse environmental conditions such as energy-starvation by entering dormant states. The fuel sources that sustain this dormant majority have yet to be resolved. Aerobic soil bacteria survive by scavenging trace gases from the atmosphere; they literally live on thin air. These ....Atmospheric trace gases: Fuelling the dormant microbial majority. This project aims to determine the physiological roles and ecological significance of hydrogen, methane and carbon monoxide scavenging. Bacteria adapt to adverse environmental conditions such as energy-starvation by entering dormant states. The fuel sources that sustain this dormant majority have yet to be resolved. Aerobic soil bacteria survive by scavenging trace gases from the atmosphere; they literally live on thin air. These trace gas scavengers are the major biological sinks in the global methane and hydrogen cycles. This project aims to study entire ecosystems of trace gas scavengers, which could enhance understanding of soil microbial ecology and biogeochemical cycling. By studying the regulation and distribution of gas scavenging, we can better model how these sinks respond to global change.Read moreRead less
The biogenesis of bacterial outer membranes; how bacteria build their surface membranes. The outer membrane protects probiotic bacteria in the human intestine and enables pathogenic bacteria to cause infectious diseases. We will determine bacteria build their outer membranes - outstanding training opportunities come through cutting edge technology and the development of skills not common in Australia.
Understanding how dynamic changes in chromatin composition control genome function. DNA is tightly packaged in eukaryotic cells as chromatin. Important genetic processes, such as transcription, require manipulation of chromatin structure to access the DNA. The cell sets up specialised chromatin structures to regulate these processes. Currently, precise molecular details of these specialised structures are limited. This project will push the envelope of an in vitro model chromatin system and dete ....Understanding how dynamic changes in chromatin composition control genome function. DNA is tightly packaged in eukaryotic cells as chromatin. Important genetic processes, such as transcription, require manipulation of chromatin structure to access the DNA. The cell sets up specialised chromatin structures to regulate these processes. Currently, precise molecular details of these specialised structures are limited. This project will push the envelope of an in vitro model chromatin system and determine the architecture of several chromatin states with unique functional implications inside the cell. This will unravel the molecular instructions that define how our genomes are organised, significantly advancing our knowledge of fundamental eukaryotic genome biology and paving the way for the future development of new tools and therapies.Read moreRead less
Testing the importance of large-scale climate factors to plant community assembly following land-use change. This project will examine the native plant species and functional diversity of Australia's rain forest communities to create a predictive framework of how plant communities recover following deforestation. Such a framework is key to focusing conservation efforts in degraded and multi-use landscapes.
Transport of nucleotide sugars and their roles in cell wall biosynthesis. This project aims to define and manipulate transporters involved in the delivery of activated sugars for cell wall polymer biosynthesis. Cell wall polymers play important structural and functional roles in plants. They also represent an important renewable resource in the form of biomass and contribute to the nutritional value of food. The project will complete the characterisation of cell wall-associated transporters, app ....Transport of nucleotide sugars and their roles in cell wall biosynthesis. This project aims to define and manipulate transporters involved in the delivery of activated sugars for cell wall polymer biosynthesis. Cell wall polymers play important structural and functional roles in plants. They also represent an important renewable resource in the form of biomass and contribute to the nutritional value of food. The project will complete the characterisation of cell wall-associated transporters, apply new technologies to visualise cell wall biosynthesis in growing plants and leverage this knowledge to manipulate biomass in rice. This information will provide fundamental knowledge on a crucial process in plants that can be used the development of functional foods for agriculture and tailored biomass for industry.Read moreRead less