Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.
Polymer nanoparticles and their assembled supracolloidal monolithic structures for applications in separation science. This project will generate new polymeric materials that will improve the analysis of complex samples. This will be applied in a wide range of areas of national importance including: pharmaceutical analysis and drug discovery; environmental, clinical and forensic analysis; and energy generation and foods.
Discovery Early Career Researcher Award - Grant ID: DE150101196
Funder
Australian Research Council
Funding Amount
$403,536.00
Summary
Elucidation and characterisation of the misfolded protein interactome. Correct expression, folding, and clearance of proteins are critical for all cell functions. However, cell stresses and aging can cause protein balance mechanisms to become overloaded, resulting in the misfolding and aggregation of proteins. Understanding the mechanisms by which protein aggregation occurs and how to prevent the process have become major scientific challenges. This project aims to gain unprecedented insights in ....Elucidation and characterisation of the misfolded protein interactome. Correct expression, folding, and clearance of proteins are critical for all cell functions. However, cell stresses and aging can cause protein balance mechanisms to become overloaded, resulting in the misfolding and aggregation of proteins. Understanding the mechanisms by which protein aggregation occurs and how to prevent the process have become major scientific challenges. This project aims to gain unprecedented insights into the interactors, effectors and fate of misfolded protein aggregates within cells, using new, cutting-edge, catalytic-tagging biochemical tools. Critical interactions will be investigated for their roles in protein aggregation cell death, and in whether modulation of the interaction can also mitigate or reverse the process.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100057
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A diffractometer for small molecule structural elucidation by crystallographic analysis. X-ray diffractometry provides an unambiguous means of identifying the three-dimensional spatial arrangement of atoms within molecules affording important insights into the origins of chemical properties. A modern diffractometer will provide information to help develop new functional materials, therapeutic agents and environmentally sustainable processes.
Advanced cluster materials for optical limiting applications. Materials with significant optical limiting properties are needed for optical device and personnel protection against accidental exposure and hostile threat from high-power lasers. Metal clusters (molecules with several metal atoms) are one of the most promising optical limiting materials known, but while their potential has been highlighted, the systematic studies needed to optimise their performance are lacking. This project will as ....Advanced cluster materials for optical limiting applications. Materials with significant optical limiting properties are needed for optical device and personnel protection against accidental exposure and hostile threat from high-power lasers. Metal clusters (molecules with several metal atoms) are one of the most promising optical limiting materials known, but while their potential has been highlighted, the systematic studies needed to optimise their performance are lacking. This project will assess the optical limiting merit of carefully targeted cluster complexes, and afford structure/property relationships to guide materials development. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100200
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Anion-templated functional architectures. This project aims to introduce a method for preparing large, complex materials from relatively simple precursors. Negatively-charged species, anions, will be used to assemble positively-charged organic molecules into three-dimensional structures, including cages and porous framework materials. This will increase fundamental understanding of how anions behave and their use in self-assembly processes. The structures made using this approach are expected to ....Anion-templated functional architectures. This project aims to introduce a method for preparing large, complex materials from relatively simple precursors. Negatively-charged species, anions, will be used to assemble positively-charged organic molecules into three-dimensional structures, including cages and porous framework materials. This will increase fundamental understanding of how anions behave and their use in self-assembly processes. The structures made using this approach are expected to remove dangerous environmental pollutants from water and store the industrially-relevant gases, hydrogen and carbon dioxide. This offers potential applications in clean energy technology (e.g. hydrogen storage for fuel cells) and environmental remediation (carbon dioxide storage, polycyclic aromatic hydrocarbon removal).Read moreRead less
Non-equilibrium material phases. This project aims to synthesise and characterise exotic materials produced in the laboratory under conditions that replicate those inside planets and stars. Highly non-equilibrium processing methods are needed to find entirely new material forms of elements and compounds created under extreme pressure and temperature. The project will use its laser-based synthesis method to explore and understand the non-equilibrium pathways and develop new materials. Understandi ....Non-equilibrium material phases. This project aims to synthesise and characterise exotic materials produced in the laboratory under conditions that replicate those inside planets and stars. Highly non-equilibrium processing methods are needed to find entirely new material forms of elements and compounds created under extreme pressure and temperature. The project will use its laser-based synthesis method to explore and understand the non-equilibrium pathways and develop new materials. Understanding how these materials form could lead to the next materials revolution. This research will lead to materials that industry sectors can exploit for commercial benefits.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100192
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomole ....Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomolecules including peptides, proteins and small molecules. The discovery of unknown compounds is expected to improve fundamental understanding of molecular structure and function, provide opportunities for new bio-industries in health and the environment, and generate commercial opportunities through spin-off companies, patents and licensing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100160
Funder
Australian Research Council
Funding Amount
$297,463.00
Summary
Femtosecond laser micropyrolysis gas chromatograph-mass spectrometer. This project aims to build a femtosecond-laser, micropyrolysis gas-chromatographmass spectrometer. The facility will have the capability to selectively analyse very small petrographically-recognisable organic components, hence bridging the analytical gap between organic petrography and organic geochemistry. The project aims to understand the early evolution of life, the response of the biosphere to mass extinction, the migrati ....Femtosecond laser micropyrolysis gas chromatograph-mass spectrometer. This project aims to build a femtosecond-laser, micropyrolysis gas-chromatographmass spectrometer. The facility will have the capability to selectively analyse very small petrographically-recognisable organic components, hence bridging the analytical gap between organic petrography and organic geochemistry. The project aims to understand the early evolution of life, the response of the biosphere to mass extinction, the migration of fluids in petroleum reservoirs, the heterogeneity of organic matter in shale gas reservoirs, and the composition of macromolecules in biominerals and macerals. The facility will contribute to a broad range of Australia’s theoretical and applied problems in geoscience and geobiology.Read moreRead less
Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will ....Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will represent a breakthrough in the field and will have a profound impact by reducing infection rates associated with medical devices and improving airway clearance in cystic fibrosis patients.Read moreRead less