New drugs for malaria that target histone deacetylases. There is no vaccine for malaria and current drugs are failing, contributing to millions of malaria-related deaths each year. The aim of this project is to develop new drugs to address this significant global health issue. This project will focus on drugs that act in novel ways to existing malaria drugs by targeting enzymes that are involved in altering gene expression in the parasite. These kinds of enzymes are recognised drug targets in ot ....New drugs for malaria that target histone deacetylases. There is no vaccine for malaria and current drugs are failing, contributing to millions of malaria-related deaths each year. The aim of this project is to develop new drugs to address this significant global health issue. This project will focus on drugs that act in novel ways to existing malaria drugs by targeting enzymes that are involved in altering gene expression in the parasite. These kinds of enzymes are recognised drug targets in other diseases such as cancer. The outcomes of this project will include advances in malaria drug development that build on Australian drug discovery efforts, seeding further funding opportunities from industry and other sources and contributing research training and capacity building in Australia.Read moreRead less
Real-Time Searches for Gravitational Waves and Identification of Their Radio and Optical Counterparts. The proposed project will directly address the national research priority in development of frontier technologies, directly involve Australians in frontier work in gravitational wave astronomy that will result in break-through sciences and improve the chance of the international Square-Kilometer-Array project being sited at Australia. In addition, it will foster a close collaboration of top int ....Real-Time Searches for Gravitational Waves and Identification of Their Radio and Optical Counterparts. The proposed project will directly address the national research priority in development of frontier technologies, directly involve Australians in frontier work in gravitational wave astronomy that will result in break-through sciences and improve the chance of the international Square-Kilometer-Array project being sited at Australia. In addition, it will foster a close collaboration of top international researchers with an Australian team. The research at The University of Western Australia will attract students from around the world and serve to educate and inspire young people in Australia.Read moreRead less
Origins of our Universe. The present proposal will study the origins of our Universe, which is one of the grand challenges of 21st century physics. As such it will utilise insights and discoveries in many areas of physics, ranging from string theory and particle physics at the highest energies, to x-ray, optical and radio astronomy. The research program will add to our understanding of a fundamental branch of science - extending it in new directions - thereby considerably boosting the quality of ....Origins of our Universe. The present proposal will study the origins of our Universe, which is one of the grand challenges of 21st century physics. As such it will utilise insights and discoveries in many areas of physics, ranging from string theory and particle physics at the highest energies, to x-ray, optical and radio astronomy. The research program will add to our understanding of a fundamental branch of science - extending it in new directions - thereby considerably boosting the quality of cosmology and theoretical physics research in Australia. In concert with our international collaborations, work arising from this fellowship will enhance the Australian presence on the international cosmology, astro-particle, and theoretical physics scene.
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Fusion Energy and the Physics of Burning Plasmas. The world faces a global energy crisis. Our standard of living, which is largely powered by base-load electricity supply, is unsustainable. Fusion power is a near zero greenhouse gas technology, which promises millions of years of base-load electricity, free from weapon proliferation. This promise has galvanised the international community to accelerate fusion development by committing to the next-step technology-enabling $16 billion experiment, ....Fusion Energy and the Physics of Burning Plasmas. The world faces a global energy crisis. Our standard of living, which is largely powered by base-load electricity supply, is unsustainable. Fusion power is a near zero greenhouse gas technology, which promises millions of years of base-load electricity, free from weapon proliferation. This promise has galvanised the international community to accelerate fusion development by committing to the next-step technology-enabling $16 billion experiment, International Thermonuclear Experimental Reactor (ITER). In anticipation of ITER, this fellowship will foster growth of Australian fusion research, and address a grand science challenge facing ITER: how do we maintain burn in the face of potentially damaging plasma instabilities? The answer will affect both ITER and the viability of fusion power.Read moreRead less