Integration of DNA switches into wearables for smart chemical monitoring. This project addresses the scientific challenge of real-time monitoring of dynamic biological changes in the secretions found in sweat. By creating a wearable wireless device to monitor chemicals which interests Nutromics, using a novel electronic skin technology platform, the work aims to generate new knowledge of physiological changes in sweat secretions. Lying at the interface of analytical chemistry, functional materia ....Integration of DNA switches into wearables for smart chemical monitoring. This project addresses the scientific challenge of real-time monitoring of dynamic biological changes in the secretions found in sweat. By creating a wearable wireless device to monitor chemicals which interests Nutromics, using a novel electronic skin technology platform, the work aims to generate new knowledge of physiological changes in sweat secretions. Lying at the interface of analytical chemistry, functional materials and biomedical engineering, the project will contribute to the training of young researchers in these emerging technologies which interest Nutromics Pty Ltd. The project will improve Australia's standing in technology around wearable devices, improving our global competitive edge with economic and scientific impact.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100056
Funder
Australian Research Council
Funding Amount
$3,975,864.00
Summary
ARC Training Centre for Next-Gen Technologies in Biomedical Analysis . The Centre for Next-Gen Technologies in Biomedical Analysis will deliver workforce trained in the development of transformative technologies that will rapidly expand the Australian pharmaceutical, diagnostic and defence sector. The university-industry partnership will increase Australia’s manufacturing capability by fast tracking screening, by integrating 3D printing, advanced sensing, big data analytics, machine learning an ....ARC Training Centre for Next-Gen Technologies in Biomedical Analysis . The Centre for Next-Gen Technologies in Biomedical Analysis will deliver workforce trained in the development of transformative technologies that will rapidly expand the Australian pharmaceutical, diagnostic and defence sector. The university-industry partnership will increase Australia’s manufacturing capability by fast tracking screening, by integrating 3D printing, advanced sensing, big data analytics, machine learning and artificial intelligence for the delivery of optimal solutions in diagnosis, treatment and wellbeing. The centre will deliver training in Industry 4.0 skills which will boost early-stage scale-up and accelerate the sector’s supply chain, which is pivotal for the Australian industries to maintain a competitive edge. Read moreRead less
Novel semio-chemical approach to control the Australian Sheep Blowfly . The Australian Federal Government through the 'Smart Farming' initiative highlights the need for improved multidisciplinary measures in order to remain at the global forefront of the invention and adoption of technology. This multidisciplinary project (entomology, biotechnology, analytical chemistry and genomics) will rapidly inform the management of fly strike on an important Australian resource merino sheep. This will bui ....Novel semio-chemical approach to control the Australian Sheep Blowfly . The Australian Federal Government through the 'Smart Farming' initiative highlights the need for improved multidisciplinary measures in order to remain at the global forefront of the invention and adoption of technology. This multidisciplinary project (entomology, biotechnology, analytical chemistry and genomics) will rapidly inform the management of fly strike on an important Australian resource merino sheep. This will build the key biochemical data in order to develop a novel fly lure technology (at scale) to be used on farm delivering national benefit through improved animal welfare and safety considerations for producers, and will establish the best approach to disseminate this scientific information to stakeholders such as farmers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560685
Funder
Australian Research Council
Funding Amount
$451,000.00
Summary
Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. Th ....Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. The bioelectrochemical imaging facility will be unique in Australia and establish an important cross-disciplinary approach within the international community.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989491
Funder
Australian Research Council
Funding Amount
$172,025.00
Summary
Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemi ....Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemistry and hydrometallurgy, aquaculture, forensic analysis, Antarctic studies, and environmental monitoring. This will directly support our work falling under National Research Priorities 1 An Environmentally Sustainable Australia, 2 Promoting and Maintaining Good Health, 3 Frontier Technologies for Building and Transforming Australian Industries, and 4 Safeguarding Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100053
Funder
Australian Research Council
Funding Amount
$482,055.00
Summary
Single Particle Elemental Analysis – Imaging Mass Cytometer Facility. This proposal aims to establish an Australian facility for next generation high resolution inductively coupled plasma time-of-flight mass spectrometry (icpTOF-MS), coupled with high speed laser ablation (LA) imaging. The facility, being the first in Australia, will allow for the entire elemental/isotopic make-up of individual particles and cells in suspension, or within a solid sample, to be performed simultaneously. This is p ....Single Particle Elemental Analysis – Imaging Mass Cytometer Facility. This proposal aims to establish an Australian facility for next generation high resolution inductively coupled plasma time-of-flight mass spectrometry (icpTOF-MS), coupled with high speed laser ablation (LA) imaging. The facility, being the first in Australia, will allow for the entire elemental/isotopic make-up of individual particles and cells in suspension, or within a solid sample, to be performed simultaneously. This is particularly significant when materials are rare, or not readily available. Expected outcomes include the generation of new knowledge and training in the industrial, biological, defence and environmental research sectors and the significant enhancement of Australia’s leadership in nanotechnology and elemental imaging.
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Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagn ....Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagnostics, forensic sample determination and industrial process monitoring through decreased analysis time with an increase in the chemical information gained. By performing chemical separations on a microfluidic scale a reduction in both the cost of analysis and impact of solvent waste on the environment will be achieved.Read moreRead less
Identification and isolation of new pharmaceutical opiate analogues: today's problems tomorrow's solutions. This project will identify and characterise the impurity profiles across opiate alkaloid production, which will enhance the development of manufacturing processes through the reduction of problem impurities and provide potential new drug substances from the isolation of other opiate derived concomitant species.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100140
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
Quarantined ion chromatography mass spectrometry (IC-MS) facility. This proposal seeks to establish a quarantined facility for 'ion chromatography-mass spectrometry', to provide high resolution ion chromatographic and mass spectrometric analytical capability to the environmental, analytical/bioanalyical, and industrial science research communities. The state-of-the-art facility will represent the only quarantined high-resolution IC-MS facility within Australia, and therefore not only support the ....Quarantined ion chromatography mass spectrometry (IC-MS) facility. This proposal seeks to establish a quarantined facility for 'ion chromatography-mass spectrometry', to provide high resolution ion chromatographic and mass spectrometric analytical capability to the environmental, analytical/bioanalyical, and industrial science research communities. The state-of-the-art facility will represent the only quarantined high-resolution IC-MS facility within Australia, and therefore not only support the above communities within Australia, but the potential to facilitate research collaboration internationally, including supporting Australia's leading Antarctic Science programs. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100043
Funder
Australian Research Council
Funding Amount
$389,000.00
Summary
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes inc ....Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes include: interdisciplinary collaborations in new protocols for in-vitro drug development; cell printing technologies; environmental impacts of microplastics; and materials design. Expected benefits include innovative approaches to early stage drug design; improved environmental controls and advances in innovative materials.Read moreRead less