Lipidomics Associated with Metabolic Syndrome, Aging and Metabolic Variation between Species. The aim is to apply state-of?the-art mass spectrometry to identify and quantify alterations in membrane lipidomes (i.e. lipid classes, molecular species, structure alterations and by-products) related to two major health problems facing Australia i.e. the Metabolic Syndrome and an Ageing population plus insight into the variation in metabolic rate between organisms. This research offers the opportunity ....Lipidomics Associated with Metabolic Syndrome, Aging and Metabolic Variation between Species. The aim is to apply state-of?the-art mass spectrometry to identify and quantify alterations in membrane lipidomes (i.e. lipid classes, molecular species, structure alterations and by-products) related to two major health problems facing Australia i.e. the Metabolic Syndrome and an Ageing population plus insight into the variation in metabolic rate between organisms. This research offers the opportunity for the development of mass spectrometry based technologies for the early clinical diagnosis of metabolic disorders plus provides a template of information for our Linkage partner (AstraZeneca) to develop pharmaceutical therapies targeting key molecular lipid species identified as critical to particular membrane functions.Read moreRead less
Establishing the role of alpha-2-macroglobulin in quality control of extracellular protein folding. The expected outcomes will provide important advances in understanding the role of alpha-2-macroglobulin (A2M) in maintaining the normal structure/function of extracellular proteins. This information may ultimately aid in the design of agents to be used to clear the body of pathological protein aggregates - potentially providing a direct economic benefit to Australia. The high novelty and broad si ....Establishing the role of alpha-2-macroglobulin in quality control of extracellular protein folding. The expected outcomes will provide important advances in understanding the role of alpha-2-macroglobulin (A2M) in maintaining the normal structure/function of extracellular proteins. This information may ultimately aid in the design of agents to be used to clear the body of pathological protein aggregates - potentially providing a direct economic benefit to Australia. The high novelty and broad significance of this work indicate that it will produce high-impact publications which will tangibly assist Australia being recognized as a major contributor to world research outcomes. This project will also provide a direct social benefit by training research students with the skills necessary to further the development of biological research in Australia.Read moreRead less
Discovering Mechanisms for Quality Control of Extracellular Protein Folding. The expected outcomes will provide important advances in understanding of how the mammalian body maintains the normal structure/function of extracellular proteins. This information may ultimately aid in the design of agents to be used to clear the body of pathological protein aggregates - potentially providing a direct economic benefit to Australia. The high novelty and broad significance of this work indicate that it w ....Discovering Mechanisms for Quality Control of Extracellular Protein Folding. The expected outcomes will provide important advances in understanding of how the mammalian body maintains the normal structure/function of extracellular proteins. This information may ultimately aid in the design of agents to be used to clear the body of pathological protein aggregates - potentially providing a direct economic benefit to Australia. The high novelty and broad significance of this work indicate that it will produce high-impact publications which will tangibly assist Australia being recognized as a major contributor to world research outcomes. This project will also provide a direct social benefit by training research students with the skills necessary to further the development of biological research in Australia. Read moreRead less