The molecular interactome and functions of circular RNAs. This project aims to identify the functions of circular RNAs, the most contemporary and enigmatic family of RNA molecules. While their abundance suggests they are important, it is unclear how they function at the molecular level. This project aims to delineate circular RNA function by systematically identifying their interacting partners at the DNA, RNA and protein levels, the so-called molecular interactome. This project will reprogram e ....The molecular interactome and functions of circular RNAs. This project aims to identify the functions of circular RNAs, the most contemporary and enigmatic family of RNA molecules. While their abundance suggests they are important, it is unclear how they function at the molecular level. This project aims to delineate circular RNA function by systematically identifying their interacting partners at the DNA, RNA and protein levels, the so-called molecular interactome. This project will reprogram embryonic stem cells to model developmental processes and is designed to validate circular RNA research. Together, the benefits include a higher-quality research workforce by mentoring students, refining fundamental tenets of RNA biology and may extend to improving health in the long-term.Read moreRead less
Molecular dynamics of steroid receptor crosstalk. This project uses state-of-the-art technology to show how steroids (for example, testosterone) affect many aspects of human life, and how these can be disrupted by chemicals and synthetic hormones. The results can be used to interpret disease, predict safety of new drugs, and to monitor risk to humans and wildlife of environmental chemicals.