Spatio-temporal modelling of Ras dependent MAP kinase activation. This project is at the heart of the national research priority 'Frontier Technologies for Building and Transforming Australian Industries'. Using cutting edge methods and techniques of systems biology, coupled with innovative experimental molecular cell biology we will construct and simulate mathematical models of the EGF-regulated MAP kinase pathway. The project will yield new insights into the fundamental mechanisms of cell sign ....Spatio-temporal modelling of Ras dependent MAP kinase activation. This project is at the heart of the national research priority 'Frontier Technologies for Building and Transforming Australian Industries'. Using cutting edge methods and techniques of systems biology, coupled with innovative experimental molecular cell biology we will construct and simulate mathematical models of the EGF-regulated MAP kinase pathway. The project will yield new insights into the fundamental mechanisms of cell signal transduction that drive cell division, differentiation and transformation and may enable the design of new anticancer therapies. Importantly, the modelling and simulation methods developed in the project will have a general applicability to other complex systems such as sustainable ecological systems.Read moreRead less
High Resolution EPR Spectroscopy - A Tool for Determining Electronic and Geometric Structure of Metalloenzymes. High resolution orientation selective pulsed EPR and END(T)OR in conjunction with computer simulation (XSophe) and computational chemistry will allow the determination of the electronic and geometric structure (distance and orientation of nuclei surrounding the metal ion(s)) of multiple redox centres in DMSOR, DorC and DMSDH to be determined. In addition pulsed ELDOR in conjunction wi ....High Resolution EPR Spectroscopy - A Tool for Determining Electronic and Geometric Structure of Metalloenzymes. High resolution orientation selective pulsed EPR and END(T)OR in conjunction with computer simulation (XSophe) and computational chemistry will allow the determination of the electronic and geometric structure (distance and orientation of nuclei surrounding the metal ion(s)) of multiple redox centres in DMSOR, DorC and DMSDH to be determined. In addition pulsed ELDOR in conjunction with molecular modelling will enable the mapping (distance and orientation) of redox centres in complex multicentered metalloproteins (DMSDH and DorC) and in protein-protein complexes (DMSOR-DorC) providing information on the pathway of electron transfer and hence the role of the pyranopterins.Read moreRead less
Charting connectivity in the healthy and diseased brain. Australia's endemic mental health burden is predicted to escalate as its population ages. This project will: (1) endow medicine with a diagnostic capability enabling earlier and more-accurate diagnosis of brain disorders and mental illnesses; and, (2) pinpoint brain circuit disruptions telltale of particular diseases. This is a world-first and promises a scientific basis for new-generation therapies and treatments. This project will enable ....Charting connectivity in the healthy and diseased brain. Australia's endemic mental health burden is predicted to escalate as its population ages. This project will: (1) endow medicine with a diagnostic capability enabling earlier and more-accurate diagnosis of brain disorders and mental illnesses; and, (2) pinpoint brain circuit disruptions telltale of particular diseases. This is a world-first and promises a scientific basis for new-generation therapies and treatments. This project will enable the APD to disseminate the specialist knowledge acquired as an ARC Fellow at Harvard in 2008 to Australian researchers, thereby advancing Australia's international standing in science.Read moreRead less