Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical pr ....Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical properties of this tissue will be of great benefit for the design of bio-inspired materials and be important for the development of advanced materials for which Australia already has an enviable reputation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989384
Funder
Australian Research Council
Funding Amount
$233,000.00
Summary
High-speed, three-dimensional, x-ray fluoroscopy for accurate measurement of human joint motion. This proposal addresses one of the most difficult and long-standing problems in the field of biomechanics: How can human joint motion be measured accurately and non-invasively during common activities such as walking, stair ambulation and running? Low-dose, high-speed, three-dimensional, x-ray fluoroscopy provides an excellent solution to this problem and, in so doing, can play a pivotal role in heal ....High-speed, three-dimensional, x-ray fluoroscopy for accurate measurement of human joint motion. This proposal addresses one of the most difficult and long-standing problems in the field of biomechanics: How can human joint motion be measured accurately and non-invasively during common activities such as walking, stair ambulation and running? Low-dose, high-speed, three-dimensional, x-ray fluoroscopy provides an excellent solution to this problem and, in so doing, can play a pivotal role in healthcare, through clinical gait analysis and gait rehabilitation (diagnosis, prevention and treatment of movement disorders); in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of physics-based animations for the video/digital games industry.Read moreRead less
Biomolecular surface interactions with smart biomaterials. Current materials used for medical implants are often recognised by the body as foreign materials causing implant rejection or encapsulation. Research into the interactions between biological molecules and chemically and topographically modified materials will aid in the development of new materials and devices that optimise the body's response to the implanted material. The new materials and surfaces developed from this research will pr ....Biomolecular surface interactions with smart biomaterials. Current materials used for medical implants are often recognised by the body as foreign materials causing implant rejection or encapsulation. Research into the interactions between biological molecules and chemically and topographically modified materials will aid in the development of new materials and devices that optimise the body's response to the implanted material. The new materials and surfaces developed from this research will provide longer lasting implants and reduce the need for repeated operations. This will improve the quality of life for implant recipients and reduce health care costs.Read moreRead less
Drug-delivery coating for a new generation of orthopaedic implants. In Australia, the number of people using artificial implants in orthopaedic and dental surgeries is rapidly increasing due to the higher average age of the population and higher expectations for an active and healthy life. The project will enhance the success rate of titanium implants by increasing the strength and stability of tissue at the interface between implant and host, particularly in case of hip joint implants, reducing ....Drug-delivery coating for a new generation of orthopaedic implants. In Australia, the number of people using artificial implants in orthopaedic and dental surgeries is rapidly increasing due to the higher average age of the population and higher expectations for an active and healthy life. The project will enhance the success rate of titanium implants by increasing the strength and stability of tissue at the interface between implant and host, particularly in case of hip joint implants, reducing the need for revision surgery. Read moreRead less
Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anti ....Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anticancer drugs. Development of such advanced drug delivery systems will significantly enhance Australia`s power in biotechnology. Development and/or formation of strategies to improve the health quality of Australians, is an important anticipated outcome of this innovative project.Read moreRead less