ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the d ....ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the design of peptides and proteins for targeted scientific, agricultural, biotechnology, animal health and pharmaceutical applications. CIPPS will assemble leading researchers from diverse disciplines to create a sustainable national entity that will drive new Australian industries and train next generation researchers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100192
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomole ....Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomolecules including peptides, proteins and small molecules. The discovery of unknown compounds is expected to improve fundamental understanding of molecular structure and function, provide opportunities for new bio-industries in health and the environment, and generate commercial opportunities through spin-off companies, patents and licensing.Read moreRead less
Undermining fungal defences by targeting their functional amyloid armour. This project will determine how a protective protein coating forms on the surface of fungal spores and infectious structures. This coating is comprised of amyloid protein fibrils and is used by fungi to improve efficiency of infection and to avoid detection by the host plant or animal. We have discovered novel small molecules that prevent the fibrils from forming. This project will use these molecules to reveal the details ....Undermining fungal defences by targeting their functional amyloid armour. This project will determine how a protective protein coating forms on the surface of fungal spores and infectious structures. This coating is comprised of amyloid protein fibrils and is used by fungi to improve efficiency of infection and to avoid detection by the host plant or animal. We have discovered novel small molecules that prevent the fibrils from forming. This project will use these molecules to reveal the details of the fibril assembly mechanism and find the best way to undermine this fungal defence system. This knowledge will enable the development of potent small molecule inhibitors to treat fungal infections that blight crops and harm animals, and the production of new layered biomaterials for nanotechnology applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100029
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
High Resolution PET-CT for Small Animal Molecular and Anatomical Imaging. This project will integrate a next generation small animal PET-CT instrument into the Sydney Imaging multi-modality imaging ecosystem. PET-CT enables the investigation of molecular function and anatomical structure in complex living organisms. This platform will enable research as diverse as the development and in-vivo characterisation of new chemical probes and nanoparticles that bind to specific protein targets in the bo ....High Resolution PET-CT for Small Animal Molecular and Anatomical Imaging. This project will integrate a next generation small animal PET-CT instrument into the Sydney Imaging multi-modality imaging ecosystem. PET-CT enables the investigation of molecular function and anatomical structure in complex living organisms. This platform will enable research as diverse as the development and in-vivo characterisation of new chemical probes and nanoparticles that bind to specific protein targets in the body, investigating mechanisms of brain plasticity in predictive learning, understanding the molecular pathways involved in neurodegeneration and cancer, developing novel methods for multi-modal image analysis, and developing and validating new radiation detectors for the next generation of imaging technology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100023
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Australian high field electron paramagnetic resonance facility. This project aims to establish Australia’s first a high-field (3 T, 94 GHz) high-field pulse electron paramagnetic resonance (EPR) facility. EPR is a powerful technique to study chemical, biological and materials systems. It represents a sensitive, non-invasive, site-selective spectroscopy for the analysis of both molecular and macroscopic properties. This facility will allow the further development and implementation of new multidi ....Australian high field electron paramagnetic resonance facility. This project aims to establish Australia’s first a high-field (3 T, 94 GHz) high-field pulse electron paramagnetic resonance (EPR) facility. EPR is a powerful technique to study chemical, biological and materials systems. It represents a sensitive, non-invasive, site-selective spectroscopy for the analysis of both molecular and macroscopic properties. This facility will allow the further development and implementation of new multidimensional pulse EPR techniques, enabling domestic and international collaborations with diverse applications in structural biology, solvation science and catalysis.Read moreRead less
Molecular study of copper-promoted ubiquitination. This project aims to study copper-promoted ubiquitination, a novel discovery that a conserved copper binding site in conjugating enzyme UBE2D2 promotes ubiquitination of a range of proteins including tumor suppressor p53. It predicts a correlation between copper homeostasis and cellular proteostasis and may rationalise an inverse relationship between Alzheimer's disease and cancer. This project will employ a range of integrated approaches to ill ....Molecular study of copper-promoted ubiquitination. This project aims to study copper-promoted ubiquitination, a novel discovery that a conserved copper binding site in conjugating enzyme UBE2D2 promotes ubiquitination of a range of proteins including tumor suppressor p53. It predicts a correlation between copper homeostasis and cellular proteostasis and may rationalise an inverse relationship between Alzheimer's disease and cancer. This project will employ a range of integrated approaches to illuminate the molecular nature of this copper action. Expected outcomes include an understanding of the molecular mechanisms of this process, and enhanced interdisciplinary collaboration. Potential benefits include new strategies to intervene in copper-related disorders.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100142
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An integrated liquid chromatography mass spectrometry nuclear magnetic resonance (LC-MS-NMR) facility for applications in proteomics and organic chemistry. This application completes the requested liquid chromatography mass spectrometry nuclear magnetic resonance (LCMS-NMR) facility and will allow the training of over 150 researchers, significantly enhancing their research productivity and translation of outcomes in areas of national importance. New breakthroughs in drug development, smart mate ....An integrated liquid chromatography mass spectrometry nuclear magnetic resonance (LC-MS-NMR) facility for applications in proteomics and organic chemistry. This application completes the requested liquid chromatography mass spectrometry nuclear magnetic resonance (LCMS-NMR) facility and will allow the training of over 150 researchers, significantly enhancing their research productivity and translation of outcomes in areas of national importance. New breakthroughs in drug development, smart materials, organic electronic materials and biomedical research require routine access to cutting edge technology. The LCMS-NMR augments the capabilities of our research teams at the forefront of these efforts. These include understanding the impact of the environment on plant and animal development, pest animal control, development of new biotechnology tools, new drugs and new methods for the detection of narcotics and explosives.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100016
Funder
Australian Research Council
Funding Amount
$850,000.00
Summary
A collaborative electron microscopy network for structural biology. This project aims to establish a high-throughput pipeline to determine the near-atomic-resolution structure of proteins by cryo-electron microscopy (cryo-EM). Over the past five years, cryo-EM has improved the study of biological macromolecules at near-atomic resolution. This project will use two automated electron microscopes and a Titan Krios microscope to build a world-competitive integrated cryo-EM network for structural bio ....A collaborative electron microscopy network for structural biology. This project aims to establish a high-throughput pipeline to determine the near-atomic-resolution structure of proteins by cryo-electron microscopy (cryo-EM). Over the past five years, cryo-EM has improved the study of biological macromolecules at near-atomic resolution. This project will use two automated electron microscopes and a Titan Krios microscope to build a world-competitive integrated cryo-EM network for structural biology. This research is expected to increase the understanding of molecular events that are central for life.Read moreRead less