A skin-on-a-chip device for investigating wound healing. This project aims to research the mechanism of skin wound healing. It will design a skin-on-a-chip microfluidic device that mimics human skin in vitro. This device will reduce the need for animal studies and assess how active compounds heal wounds. This project will design smart polymers with superior properties for controlled delivery of multiple active compounds in this device and choose the most effective combination of compounds to boo ....A skin-on-a-chip device for investigating wound healing. This project aims to research the mechanism of skin wound healing. It will design a skin-on-a-chip microfluidic device that mimics human skin in vitro. This device will reduce the need for animal studies and assess how active compounds heal wounds. This project will design smart polymers with superior properties for controlled delivery of multiple active compounds in this device and choose the most effective combination of compounds to boost skin healing rate. This knowledge may ultimately be used to develop wound dressings that maximise healing rate for various skin defects such as chronic wounds and decrease health care costs.Read moreRead less
Scalable, high throughput microfluidic platforms for tissue specific biomaterials development and tissue genesis. The co-development of novel biomaterial platforms and new generation production methods for tissue analogues will provide the necessary stimulus for improved and more relevant methods of enhanced repair or regeneration of diseased or damaged tissues. These outcomes will result in faster time-to-market new generation therapeutic products for Australia and the world. These advances wil ....Scalable, high throughput microfluidic platforms for tissue specific biomaterials development and tissue genesis. The co-development of novel biomaterial platforms and new generation production methods for tissue analogues will provide the necessary stimulus for improved and more relevant methods of enhanced repair or regeneration of diseased or damaged tissues. These outcomes will result in faster time-to-market new generation therapeutic products for Australia and the world. These advances will have a significant impact on our healthcare costs and the quality of life for all Australians.Read moreRead less
Development of a Novel Process for the Formation of Polymer Vesicles. The project would provide an increased understanding of polymer structures, polymer-drug interactions and dense gas processing of polymers. The novel process developed would be beneficial on a manufacturing level since it dramatically reduces processing time and minimises energy requirements. The research to be conducted is leading-edge technology that will attract business from international polymer, drug and biotechnology co ....Development of a Novel Process for the Formation of Polymer Vesicles. The project would provide an increased understanding of polymer structures, polymer-drug interactions and dense gas processing of polymers. The novel process developed would be beneficial on a manufacturing level since it dramatically reduces processing time and minimises energy requirements. The research to be conducted is leading-edge technology that will attract business from international polymer, drug and biotechnology companies. The development of world-class research provides Australia with recognition as a world leader in the field and strengthens and broadens the knowledge base of Australian scientists and engineers.Read moreRead less
Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within th ....Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within the Designated Research Priority of Frontier Technologies for Building and Transforming Australian Industries. Read moreRead less
Engineering of cartilage-based biomaterials under dynamic culture conditions. This work contributes to the development of advanced technologies in the area of biomaterials. The cartilage biomaterials generated in this work will lead to new medical applications in tissue reconstruction and replacement, which is of direct benefit to society by improving the methods used to treat joint disease and injury. As there is a significant commercial market for tissue-engineered cartilage products, this res ....Engineering of cartilage-based biomaterials under dynamic culture conditions. This work contributes to the development of advanced technologies in the area of biomaterials. The cartilage biomaterials generated in this work will lead to new medical applications in tissue reconstruction and replacement, which is of direct benefit to society by improving the methods used to treat joint disease and injury. As there is a significant commercial market for tissue-engineered cartilage products, this research also has implications for enhancing the scope and profitability of the Australian biotechnology industry. The project will be a vehicle for research training in a broad range of interdisciplinary areas. Students involved in the work will be equipped with a versatile and valuable combination of skills.Read moreRead less
Clean technologies for the synthesis and purification of a biohybrid and biodegradable polymer. The project aims to transform an Australian industry in the forefront of the global market for manufacturing biodegradable polymers and boost export earnings derived from CO2 based biohybrid polymers. The project will develop cost-effective and clean methods for processing CO2 based polymers and demonstrate its potential for packaging and biomedical applications.