Drawing out spider silk photonics and technology. We discovered certain spider webs are an optical device of amazing sophistication – the result of 136 million years of evolution. New photonic and electron microscopy techniques will measure the unique optical and materials properties of the webs, and the resulting knowledge will have high impact for advanced, self- assembled, photonic materials.
Nanoscope-in-a-needle: nanoscale imaging and sensing deep inside tissue. This project seeks to make possible nanoscale and microscale imaging deep inside living human tissue. By miniaturising advanced optical imaging, sensing and spectroscopy systems into a hypodermic needle – a nanoscope-in-a-needle – it would be possible to study the structure and function of living biological systems in their native, three-dimensional environment up to centimetres deep in soft tissue but with unprecedented n ....Nanoscope-in-a-needle: nanoscale imaging and sensing deep inside tissue. This project seeks to make possible nanoscale and microscale imaging deep inside living human tissue. By miniaturising advanced optical imaging, sensing and spectroscopy systems into a hypodermic needle – a nanoscope-in-a-needle – it would be possible to study the structure and function of living biological systems in their native, three-dimensional environment up to centimetres deep in soft tissue but with unprecedented nano- and micro-scale resolution. A suite of new nanoscopes would underpin biological discovery and help advance human health and wellbeing.Read moreRead less
Neural mechanisms of vestibular perception in zebrafish. This project aims to understand vestibular processing by removing physical movement. The vestibular system allows us to perceive gravity and movement, but it is not understood how the brain processes information from vestibular sensors in the inner ear. This project will exert forces on the zebrafish’s inner ear with a laser, stimulating the vestibular sense. This means that the animal will experience vestibular stimuli while stationary, a ....Neural mechanisms of vestibular perception in zebrafish. This project aims to understand vestibular processing by removing physical movement. The vestibular system allows us to perceive gravity and movement, but it is not understood how the brain processes information from vestibular sensors in the inner ear. This project will exert forces on the zebrafish’s inner ear with a laser, stimulating the vestibular sense. This means that the animal will experience vestibular stimuli while stationary, allowing calcium imaging of neurons that respond to vestibular cues and optogenetics to stimulate or silence these neurons. This is expected to reveal which cells and circuits mediate vestibular perception, processing and behaviour.Read moreRead less
Targeted light - optical mode control at the nanoscale. Nanophotonics provides a path for controlling the interaction of light and matter at the nanoscale. Using spatially tailored laser beams to address nano-particles, this project aims to create new approaches for specifically targeting light with nano-scale precision, which has valuable potential applications in biosensing and communications.
Probe-free biophysical force and torque measurements with optical tweezers. This project aims to develop probe-free biophysical force and torque measurement methods based on optical tweezers. Many areas of research in cell biology are hampered by a lack of quantitative force measurements. This project aims to provide accurate quantitative measurements to enable in-depth understanding of forces at work during cell division, properties of blood cells and sperm motility which could generate further ....Probe-free biophysical force and torque measurements with optical tweezers. This project aims to develop probe-free biophysical force and torque measurement methods based on optical tweezers. Many areas of research in cell biology are hampered by a lack of quantitative force measurements. This project aims to provide accurate quantitative measurements to enable in-depth understanding of forces at work during cell division, properties of blood cells and sperm motility which could generate further research leading to health benefits.Read moreRead less
Imaging the invisible. This project aims to develop imaging technology to see and quantify objects normally invisible with X-rays. It will develop an X-ray imaging system that should provide orders of magnitude greater sensitivity to subtle changes in material composition than conventional radiography. It will devise quantitative image analysis tools for isolating specific materials of interest from complex multi-material samples, including low density components that often go undetected. Indust ....Imaging the invisible. This project aims to develop imaging technology to see and quantify objects normally invisible with X-rays. It will develop an X-ray imaging system that should provide orders of magnitude greater sensitivity to subtle changes in material composition than conventional radiography. It will devise quantitative image analysis tools for isolating specific materials of interest from complex multi-material samples, including low density components that often go undetected. Industries that could benefit significantly from this technology include airport security, the mining sector, agriculture, manufacturing quality control, and biomedical researchers studying anatomical form and function.Read moreRead less
Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible ....Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible with next-generation lab-on-a-chip technologies and permit rapid throughput diagnostics with potential applications in biomedicine and materials science. Expected project outcomes may also underpin fundamental advances in understanding the interaction of light with nanostructures.Read moreRead less
Probing nanoscale disorder in 3D with x-ray free-electron lasers. This project aims to reveal the 3D nanostructure of disordered matter with x-rays for the first time. Existing x-ray scattering techniques for disordered structures currently provide limited, one-dimensional information only. The expected outcomes of the project include an enhanced new capability for the Australian Synchrotron and international x-ray laser facilities, and new insights into the microscopic origins of the properties ....Probing nanoscale disorder in 3D with x-ray free-electron lasers. This project aims to reveal the 3D nanostructure of disordered matter with x-rays for the first time. Existing x-ray scattering techniques for disordered structures currently provide limited, one-dimensional information only. The expected outcomes of the project include an enhanced new capability for the Australian Synchrotron and international x-ray laser facilities, and new insights into the microscopic origins of the properties of liquids and biological membranes. This should benefit research areas that use x-ray scattering to probe the nanostructure of materials for diverse applications such as nanotechnology, fuel cells and drug design.Read moreRead less
Enhancing gravitational wave detector sensitivity and bandwidth for astronomy. This project aims to create small optomechanical devices that amplify the signals in gravitational wave detectors, increasing their sensitivity, especially for higher frequency signals. Calibrated against the 2015 first detection of gravitational waves from black hole mergers, this technology could allow humanity to listen to black holes merging up to 30 times every day, while giving much greater sensitivity to signal ....Enhancing gravitational wave detector sensitivity and bandwidth for astronomy. This project aims to create small optomechanical devices that amplify the signals in gravitational wave detectors, increasing their sensitivity, especially for higher frequency signals. Calibrated against the 2015 first detection of gravitational waves from black hole mergers, this technology could allow humanity to listen to black holes merging up to 30 times every day, while giving much greater sensitivity to signals from smaller black holes and neutron stars. The new technology, which uses nano-scale suspended tiny mirrors controlled by laser light, is likely to have applications in making sensors and quantum devices for advanced instrumentation, improve mineral exploration and measure tiny electromagnetic signals.Read moreRead less
Dual nanoparticles to distinguish between right and left biomolecules. This project aims to enhance the sensitivity of optical activity to ultralow molecular concentration samples. Optical activity is a commercially available technique used to distinguish chemically identical and morphologically different biomolecules (enantiomers). Unlike other scattering techniques, near-field enhancing of optical activity has not been achieved, thus limiting these measurements to high molecular concentrations ....Dual nanoparticles to distinguish between right and left biomolecules. This project aims to enhance the sensitivity of optical activity to ultralow molecular concentration samples. Optical activity is a commercially available technique used to distinguish chemically identical and morphologically different biomolecules (enantiomers). Unlike other scattering techniques, near-field enhancing of optical activity has not been achieved, thus limiting these measurements to high molecular concentrations. There is evidence indicating that optical activity can be enhanced using dual nanoparticles (ie small particles with the same response to electric and magnetic fields). This project aims to advance our understanding of these dual nanoparticles and experimentally implement their use to enhance optical activity.Read moreRead less