Improving the stability of biomolecules using ionic liquids. This project aims to address critical issues in studying proteins outside their native environments by developing new solvents that will increase their stability and solubility. The project expects to create new knowledge in our understanding of solvent chemical properties through a novel approach using high throughput robotics, synchrotron analysis of protein structures and Molecular Dynamics simulations. The expected outcome is a set ....Improving the stability of biomolecules using ionic liquids. This project aims to address critical issues in studying proteins outside their native environments by developing new solvents that will increase their stability and solubility. The project expects to create new knowledge in our understanding of solvent chemical properties through a novel approach using high throughput robotics, synchrotron analysis of protein structures and Molecular Dynamics simulations. The expected outcome is a set of design rules for creating new solvents. This should benefit many research and industrial applications, including determining protein structure for the development of new drugs and biocatalysts, and cryopreservation of protein-based pharmaceuticals.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100138
Funder
Australian Research Council
Funding Amount
$419,804.00
Summary
Developing Switchable Ligands to Control Gold Nanocluster Interfaces. This project aims to unlock the promising catalytic activity of protected gold nanoclusters by developing switchable ligands capable of undergoing controlled detachment and exchange. This project expects to provide a detailed understanding of how the gold thiolate interface of nanoclusters influences their physical and chemical properties. Expected outcomes include the design of improved catalysts for chemical synthesis and bi ....Developing Switchable Ligands to Control Gold Nanocluster Interfaces. This project aims to unlock the promising catalytic activity of protected gold nanoclusters by developing switchable ligands capable of undergoing controlled detachment and exchange. This project expects to provide a detailed understanding of how the gold thiolate interface of nanoclusters influences their physical and chemical properties. Expected outcomes include the design of improved catalysts for chemical synthesis and biological assays using computer aided chemical modelling. These catalysts should be easier to recover after use, which should improve cost-effectiveness. They should also improve the accuracy of biological sensors, which could ultimately be used for the rapid and early detection of diseases.Read moreRead less
Autonomous Discovery of Green Inhibitors. The project aims to develop autonomous material design by integrating evolutionary algorithms and robotic experimentation. The project expects to pioneer a new method of materials discovery that could cut discovery times to 20% of traditional methods. Its expected to have significance through its discovery of new classes of corrosion inhibitors that are safe to both humans and the environment. The expected outcomes of this project will be a rapid disc ....Autonomous Discovery of Green Inhibitors. The project aims to develop autonomous material design by integrating evolutionary algorithms and robotic experimentation. The project expects to pioneer a new method of materials discovery that could cut discovery times to 20% of traditional methods. Its expected to have significance through its discovery of new classes of corrosion inhibitors that are safe to both humans and the environment. The expected outcomes of this project will be a rapid discovery methodology that can be used across materials science and new classes of safe corrosion inhibitors. This should provide significant benefits to workplace n safety and the environmental impact of the coatings industry while also increasing the rapid of innovation of new materials.Read moreRead less