Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a bas ....Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a base template for novel nanosilver engineering with less tendency for resistance development and to facilitate tracking of resistance and its spread amongst microorganisms. The knowledge has far-reaching implications on the better governance of nanosilver use, including its disposal.Read moreRead less
Rational Design of Novel Multiferroic Materials for Energy Harvesting and Energy Efficiency. Multiferroics are a class of fundamentally complex materials in which several ferroic orders (for example, ferroelectric and ferromagnetic) coexist. The coupling between their electric and magnetic degrees of freedom is controllable via stress and external fields, thus opening the possibility for breakthrough technological developments. By working at the frontier of complex nanostructured oxide materials ....Rational Design of Novel Multiferroic Materials for Energy Harvesting and Energy Efficiency. Multiferroics are a class of fundamentally complex materials in which several ferroic orders (for example, ferroelectric and ferromagnetic) coexist. The coupling between their electric and magnetic degrees of freedom is controllable via stress and external fields, thus opening the possibility for breakthrough technological developments. By working at the frontier of complex nanostructured oxide materials, this project aims to establish the rational basis for systematic design of novel artificially layered multiferroics, develop accurate and computationally affordable methods to simulate these materials under finite-temperature conditions, and exploit this knowledge to devise likely revolutionary photovoltaic, nanoelectronic and energy conversion applications.Read moreRead less
Design of Functionalized Mesoporous Fullerenes for Clean Energy. This project aims to design multifunctional, noble metal-free, and highly ordered mesoporous fullerene with a high conductivity and different porous structures, functionalised with nitrogen and/or metal and metal oxide nanoparticles in both powder and film forms. The most promising, stable, and highly efficient noble metal-free electrode catalyst system will be designed with the functionalised mesoporous fullerenes for polymer elec ....Design of Functionalized Mesoporous Fullerenes for Clean Energy. This project aims to design multifunctional, noble metal-free, and highly ordered mesoporous fullerene with a high conductivity and different porous structures, functionalised with nitrogen and/or metal and metal oxide nanoparticles in both powder and film forms. The most promising, stable, and highly efficient noble metal-free electrode catalyst system will be designed with the functionalised mesoporous fullerenes for polymer electrolyte membrane and direct methanol fuel cells. This novel highly efficient and low cost electrode system for fuel cells aims to help address clean energy generation and environmental problems and create new opportunities for Australian industries.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102967
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Interaction between silver ions, silver nanoparticles and reactive oxygen species: implication to toxicity. The project investigates the ability of various different (supported and stabilised) types of nanosized silver particles (SNPs) to oxidatively degrade selected contaminants and or kill microorganism. The project also aims to determine the effect of solution condition (for example pH) and light on SNP longevity and hence their oxidative capacity.