Assembly and function of arabinogalactan-proteins: a class of proteoglycans involved in plant growth and development. We aim to define the mechanisms by which a family of cell surface proteoglycans, the arabinogalactan-proteins (AGPs), are assembled and contribute to the regulation of plant growth and development using Arabidopsis, a model system amenable to a functional genomics strategy. This will be achieved through the application of bioinformatics for gene discovery and molecular, biochemi ....Assembly and function of arabinogalactan-proteins: a class of proteoglycans involved in plant growth and development. We aim to define the mechanisms by which a family of cell surface proteoglycans, the arabinogalactan-proteins (AGPs), are assembled and contribute to the regulation of plant growth and development using Arabidopsis, a model system amenable to a functional genomics strategy. This will be achieved through the application of bioinformatics for gene discovery and molecular, biochemical and genetics approaches to define gene function. Understanding mechanisms that control plant growth and development will ultimately impact on industries (agriculture, horticulture and forestry) vital to Australia's prosperity.Read moreRead less
Assembly and function of arabinogalactan-proteins: a class of proteoglycans involved in plant growth and development. Achievements of the Objectives will specifically address National Research Priority 3 by developing breakthrough science and utilising frontier technologies with application to Australia's agri-biotechnology industries. In addition to contributing to world class research outcomes, we will train highly skilled graduates and postdoctoral fellows in functional genomics technologies, ....Assembly and function of arabinogalactan-proteins: a class of proteoglycans involved in plant growth and development. Achievements of the Objectives will specifically address National Research Priority 3 by developing breakthrough science and utilising frontier technologies with application to Australia's agri-biotechnology industries. In addition to contributing to world class research outcomes, we will train highly skilled graduates and postdoctoral fellows in functional genomics technologies, thereby contributing to the "knowledge nation".Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560722
Funder
Australian Research Council
Funding Amount
$512,744.00
Summary
High-speed Ultracentrifuge Facility with Sensitive Scanning Optics for the Analysis of Interacting Biomolecules. This request is for a high-speed analytical ultracentrifuge equipped with sensitive absorbance, fluorescence, and interference scanning optics. The equipment, the first of its kind in Australia, would establish a world-class facility for analysing the size, shape, and stability of macromolecular complexes and their interactions in solution. This new facility will enable high through ....High-speed Ultracentrifuge Facility with Sensitive Scanning Optics for the Analysis of Interacting Biomolecules. This request is for a high-speed analytical ultracentrifuge equipped with sensitive absorbance, fluorescence, and interference scanning optics. The equipment, the first of its kind in Australia, would establish a world-class facility for analysing the size, shape, and stability of macromolecular complexes and their interactions in solution. This new facility will enable high through-put screening of small molecules with potential as new drugs. This core platform technology will cover the range of needs from basic research through to commercialization of discovery. The equipment will support existing high quality research projects in biotechnology and provide new opportunities for post-graduate training and international collaboration.Read moreRead less
Dissecting the Indigo Pathway in Natural Indigo Producing Plants: Intricate Pathway Engineering for the Generation of Blue-Fibre Cotton. Australian cotton growers must maintain a sustained competitive advantage in the future to compete within the global cotton market by commanding higher margins for specialty cotton lint over and above current revenues. Development, via biotechnology, of naturally-colored, 'blue' lint cottons is the technical goal, where novel environmentally-benign textile prod ....Dissecting the Indigo Pathway in Natural Indigo Producing Plants: Intricate Pathway Engineering for the Generation of Blue-Fibre Cotton. Australian cotton growers must maintain a sustained competitive advantage in the future to compete within the global cotton market by commanding higher margins for specialty cotton lint over and above current revenues. Development, via biotechnology, of naturally-colored, 'blue' lint cottons is the technical goal, where novel environmentally-benign textile products could be produced without the use of toxic synthetic dyes or caustic dyeing processes. Success will provide a unique opportunity to re-establish an Australian cotton/textile industry by allowing direct participation in the development, branding and marketing of novel Australian textile products, generating potential revenue upwards of $10B/year. Read moreRead less
Engineering of anti-platelet antibodies for the diagnosis and therapy of infants with bleeding disorders. Foeto-maternal alloimmune thrombocytopenia (FMAIT) is a serious clinical condition where infants suffer potentially fatal bleeding disorders from 14 weeks gestation to 1-2 weeks post delivery. The cause of the disease is through maternal antibodies destroying foetal platelets. Our aim is to produce human antibodies, which will be used as diagnostic agents to screen for the condition in preg ....Engineering of anti-platelet antibodies for the diagnosis and therapy of infants with bleeding disorders. Foeto-maternal alloimmune thrombocytopenia (FMAIT) is a serious clinical condition where infants suffer potentially fatal bleeding disorders from 14 weeks gestation to 1-2 weeks post delivery. The cause of the disease is through maternal antibodies destroying foetal platelets. Our aim is to produce human antibodies, which will be used as diagnostic agents to screen for the condition in pregnant women, and to further develop such antibodies for therapy. Identification of mothers at risk of FMAIT and the development of a specific therapy are vital to the management and prevention of this serious condition.Read moreRead less
In vivo imaging of the immune system in self tolerance and infectious disease. This proposal will introduce sophisticated imaging technology into our cutting-edge research program. Our approach will permit high resolution imaging of the immune response within an intact animal; currently not possible in Australia at the present time. The unique combination of technology and biological resources will significantly advance knowledge in key areas of basic immunology research. It will provide local ....In vivo imaging of the immune system in self tolerance and infectious disease. This proposal will introduce sophisticated imaging technology into our cutting-edge research program. Our approach will permit high resolution imaging of the immune response within an intact animal; currently not possible in Australia at the present time. The unique combination of technology and biological resources will significantly advance knowledge in key areas of basic immunology research. It will provide local researchers insights into how the body responds to infectious disease and immune-related disorders and be directly applicable to vaccine design. The facility and related research program will undoubtedly attract a team of top-level national and international scientists and students keen to work with this advanced technology.Read moreRead less