Polymer nanodiscs. This project aims to produce disc-shaped polymer nanomaterials by utilising a new self-assembly concept based on oppositely charged polymers. This project expects to generate a modular technology that allows synthesis and control over the geometry and functionality of polymer nanoparticles. This level of control will permit a precise investigation of polymer nanodisc properties for nanomedicine applications. Expected outcomes of this project will be the fundamental understandi ....Polymer nanodiscs. This project aims to produce disc-shaped polymer nanomaterials by utilising a new self-assembly concept based on oppositely charged polymers. This project expects to generate a modular technology that allows synthesis and control over the geometry and functionality of polymer nanoparticles. This level of control will permit a precise investigation of polymer nanodisc properties for nanomedicine applications. Expected outcomes of this project will be the fundamental understanding of how nanoparticle geometry affects particle-cell interaction and how nanoscale polymer discs can be used to mimic biological nanoparticles in shape and function.Read moreRead less
Functional molecular nanomaterials. The design and construction of advanced nanomaterials is a key step in the push towards more efficient energy systems and smarter technologies. Through the strategic assembly of new classes of molecular nanomaterials, this project will lead to important fundamental advances in nanoscience and will underpin a range of new high-level technologies.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100128
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
High performance analytical tools to strengthen clean energy research. High performance analytical tools are vital to the success of emerging research fields of national priority. By filling a gap in materials routine characterisation capabilities, the equipment requested will lead to major advances in fundamental and applied research aimed at carbon abatement and clean energy technologies. This includes technologies for clean energy generation by solar means and from decarbonised fossil fuels, ....High performance analytical tools to strengthen clean energy research. High performance analytical tools are vital to the success of emerging research fields of national priority. By filling a gap in materials routine characterisation capabilities, the equipment requested will lead to major advances in fundamental and applied research aimed at carbon abatement and clean energy technologies. This includes technologies for clean energy generation by solar means and from decarbonised fossil fuels, efficient energy storage systems, advanced fuel cells for electricity generation, and hydrogen as the universal energy vector. Advancement of these technologies will bring solutions to the grand challenges facing Australia and in turn benefit industry and society.
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Next-generation lithography: photo-directing assembly of block copolymers. This project aims to introduce a novel approach to organising block polymers through the photochemical modification of the surface of a photo-sensitive polymer. Chemo-epitaxy is the science of organising materials on a surface decorated with chemical patterns. The process has the potential to revolutionise the manufacture of integrated circuits, enabling faster processors. This project expects to introduce innovative conc ....Next-generation lithography: photo-directing assembly of block copolymers. This project aims to introduce a novel approach to organising block polymers through the photochemical modification of the surface of a photo-sensitive polymer. Chemo-epitaxy is the science of organising materials on a surface decorated with chemical patterns. The process has the potential to revolutionise the manufacture of integrated circuits, enabling faster processors. This project expects to introduce innovative concepts in polymer chemistry and nanoscale assembly with the potential to advance a multi-billion-dollar industry.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100052
Funder
Australian Research Council
Funding Amount
$2,500,000.00
Summary
Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling ....Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling molecule and genes to cells. The project aims to inform future optimal design criteria for bespoke nanoparticle delivery systems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100007
Funder
Australian Research Council
Funding Amount
$386,500.00
Summary
A modular toolbox of novel polymer nanorods for better tissue penetration. This project aims to establish a suite of design parameters to provide new avenues for understanding and manipulating tissue infiltration by future therapeutic nanoparticles. The project expects to develop an innovative technology that allows independent control over nanoparticle geometry, functionality, and mechanical and surface properties. This level of control over the synthesis of polymer nanoparticles with distinct ....A modular toolbox of novel polymer nanorods for better tissue penetration. This project aims to establish a suite of design parameters to provide new avenues for understanding and manipulating tissue infiltration by future therapeutic nanoparticles. The project expects to develop an innovative technology that allows independent control over nanoparticle geometry, functionality, and mechanical and surface properties. This level of control over the synthesis of polymer nanoparticles with distinct physicochemical properties will enable precise adjustment and investigation of discrete particle properties. The project will reshape fundamental knowledge of nanoparticle design by demonstrating the centrality of particle shape, stiffness, and heterogeneity. The outcomes will significantly advance the science of polymer nanoparticle synthesis control, aiding the development of novel and more effective polymer nano-therapeutics.Read moreRead less
Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailor ....Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailored towards bioactive and biocompatible material to create a drug delivery platform for more efficient disease treatment. The outcome will be better understanding on how polymer platelets can be obtained and how they compare in their biological activity with spherical nanoparticles.Read moreRead less