Group 13 Mixed Halide-Hydride and Rare Earth Complexes - New Selective Chiral Hydridic or Low Valent Reducing Agents. This project will make a landmark contribution to two areas of metallohydride chemistry. Both studies will utilise and develop metals that have traditionally been mined and exported from these shores while concurrently imported as value added products at vastly inflated cost. This research will identify knock-on applications in order to stem this financial bias. The new paths to ....Group 13 Mixed Halide-Hydride and Rare Earth Complexes - New Selective Chiral Hydridic or Low Valent Reducing Agents. This project will make a landmark contribution to two areas of metallohydride chemistry. Both studies will utilise and develop metals that have traditionally been mined and exported from these shores while concurrently imported as value added products at vastly inflated cost. This research will identify knock-on applications in order to stem this financial bias. The new paths to rare earth (= Ln) hydrides will have broad industrial appeal, particularly for new materials, where, like similar group 13 materials, they may be used in the deposition of Ln films or even as precursors to superconducting solids. It is anticipated industrial collaboration will ensue. Australia will be promoted as a developer and innovator of frontier technologies.Read moreRead less
New Boron and Gadolinium Agents for Neutron Capture Therapy. The development of new drugs and treatments for cancer is highly important for improved health outcomes and the well-being of the community. This research has the potential to result in the development of new anticancer pharmaceuticals that will dramatically expand the clinical efficacy of a promising treatment for highly aggressive tumours. The innovative nature of this research will also contribute to Australia's science knowledge ....New Boron and Gadolinium Agents for Neutron Capture Therapy. The development of new drugs and treatments for cancer is highly important for improved health outcomes and the well-being of the community. This research has the potential to result in the development of new anticancer pharmaceuticals that will dramatically expand the clinical efficacy of a promising treatment for highly aggressive tumours. The innovative nature of this research will also contribute to Australia's science knowledge base, a key element in its future economic prosperity, and it will provide excellent training of young researchers for employment in the rapidly expanding field of drug design and development.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237664
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT- ....High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT-ICR-MS will provide key structural information on a wide range of synthetic and natural chemical substances, including sequence (e.g. peptides) and fragmentation patterns, while the MALDI-TOF instrument will be used primarily for high through-put proteomic analyses.Read moreRead less
Thallium hydride complexes - synthesis, stabilisation and synthetic utility. Australia has abundant geological deposits of group 13 metals. The hydride chemistries of group 13 elements are critical to modern applications of these elements. There are no hydrides of thallium, the heaviest member of group 13. This project aims to prepare and stabilise thallium hydrides to enable technological applications of thallium.
Mitochondrial targeting by a new class of gadolinium agents. This research project will lead to the development of new molecular agents containing the element gadolinium which can selectively accumulate within cell mitochondria, with a long-term application in cutting-edge therapies involving X-rays or neutrons. The lanthanoid element gadolinium offers many unique opportunities for medicinal chemistry and this project will generate new knowledge in bioinorganic chemistry and synchrotron science. ....Mitochondrial targeting by a new class of gadolinium agents. This research project will lead to the development of new molecular agents containing the element gadolinium which can selectively accumulate within cell mitochondria, with a long-term application in cutting-edge therapies involving X-rays or neutrons. The lanthanoid element gadolinium offers many unique opportunities for medicinal chemistry and this project will generate new knowledge in bioinorganic chemistry and synchrotron science. The expected outcomes of this research will address many of the unresolved questions regarding mitochondrially-targeted gadolinium complexes, the first such agents specifically designed for potential long-term application in binary therapies and imaging.Read moreRead less
Boron and silicon based pincer ligands for environmentally responsible catalysis. The production of everyday chemicals (pharmaceuticals, agrochemicals, polymers) comes at a price, economic and environmental. Metal catalysts significantly reduce the environmental impact of both the associated energy requirements and waste products. New classes of catalysts will be developed based on the unconventional elements boron and silicon.
The development of carboranes as new agents in the diagnosis and treatment of brain disease. The treatment of brain diseases is one of society's major challenges. To address these challenges, we need a better understanding of the molecular mechanisms involved in brain disease. This project will develop innovative agents to probe disease progression, assess efficacy of treatment, and ultimately treat a wide range of brain disorders.
New frontiers in the therapeutic application of gadolinium. This research involves the design and development of new anticancer agents that will dramatically expand the clinical efficacy of a promising treatment for highly aggressive tumours. The innovative nature of this research will also contribute to Australia's science knowledge base and provide excellent training in the area of drug discovery.