Parametric Brain Imaging via Modeling and Analysis of Electroencephalographic Signals. Parameters of brain function and physiology will be spatially imaged with high time resolution via their effects on electroencephalographic (EEG) signals, a form of imaging that is impossible with existing methods. This will be achieved by improving existing physiologically-based models of the generation of EEGs and developing analysis tools based on fitting of model predictions to multielectrode EEG data. T ....Parametric Brain Imaging via Modeling and Analysis of Electroencephalographic Signals. Parameters of brain function and physiology will be spatially imaged with high time resolution via their effects on electroencephalographic (EEG) signals, a form of imaging that is impossible with existing methods. This will be achieved by improving existing physiologically-based models of the generation of EEGs and developing analysis tools based on fitting of model predictions to multielectrode EEG data. The results will be used to probe spatiotemporal features of EEGs in normal subjects to explore the underlying fundamental mechanisms and to infer novel parameter variations of practical relevance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100009
Funder
Australian Research Council
Funding Amount
$1,064,000.00
Summary
Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications. Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications: Ultra-high field magnetic resonance imaging provides unique high contrast images at previously inaccessible levels of resolution (<0.1mm). It non-invasively provides unprecedented information on chemical and biochemical processes including functional biological mechanisms. This infrastructure will be the focal point for ....Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications. Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications: Ultra-high field magnetic resonance imaging provides unique high contrast images at previously inaccessible levels of resolution (<0.1mm). It non-invasively provides unprecedented information on chemical and biochemical processes including functional biological mechanisms. This infrastructure will be the focal point for more than 100 academics and HDR students. It will take Australia to the forefront of magnetic resonance imaging capability as well as providing unique insights into diffusion and electrophoretic problems central to designing next generation energy storage. Outcomes will range from agricultural advances, higher performing batteries, and more effective cancer treatments as well advancing Australia's fundamental scientific capabilities.Read moreRead less
Novel Transmission Scanning and Computational Strategies for Quantitative microPET Imaging. Advances in detector technologies have led to the development and commercialisation of small animal imaging systems such as microPET which provide high resolution images of radioactive compounds in live animals, but the images can only be interpreted qualitatively. Our aim is to develop quantitative technologies for these new imaging systems. Major outcomes will include novel methods of measuring and corr ....Novel Transmission Scanning and Computational Strategies for Quantitative microPET Imaging. Advances in detector technologies have led to the development and commercialisation of small animal imaging systems such as microPET which provide high resolution images of radioactive compounds in live animals, but the images can only be interpreted qualitatively. Our aim is to develop quantitative technologies for these new imaging systems. Major outcomes will include novel methods of measuring and correcting for signal loss due to photon interactions in the body and integrated image reconstruction algorithms. This will lead to a new generation of quantitative imaging devices; the new technologies will be directly translatable to clinical imaging systems and will broaden the range of microPET applications in the life sciences.Read moreRead less
A hybrid magnetic resonance imaging: linear accelerator (Magnetic resonance imaging-Linac) for highly accurate radiotherapy cancer treatment. Radiotherapy is often used to treat cancer, however it is very difficult to ensure the radiation doses the tumour properly as the tumour moves during treatment due to breathing. This project will produce an image-guidance system that will allow much better targeting of the treatment and thus produce better outcomes.
Nanoparticle radiosensitisation. This project aims to develop new knowledge through a better understanding of physics interactions of particles in compounds with sub-micron size. Research on radiosensitisation by sub-micrometre sized nanoparticles (NPs) is hot worldwide because it could treat cancer, but the physical/physico-chemical/biological mechanism of radiosensitisation is unclear because no physical models describe particle interactions at nanometre scale in solid state nanometre sized ob ....Nanoparticle radiosensitisation. This project aims to develop new knowledge through a better understanding of physics interactions of particles in compounds with sub-micron size. Research on radiosensitisation by sub-micrometre sized nanoparticles (NPs) is hot worldwide because it could treat cancer, but the physical/physico-chemical/biological mechanism of radiosensitisation is unclear because no physical models describe particle interactions at nanometre scale in solid state nanometre sized objects. This project will develop and evaluate specialised physics models to describe particle interactions in NPs and help optimise nanoparticle technology. It will develop expertise in Australia in physics modelling for nanomedicine and other applications of nanotechnology exposed to radiation (e.g. telecommunications, aviation and space).Read moreRead less
Novel technologies for motion-compensated simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) imaging. The aim of this work is to develop motion tracking and motion correction techniques for an emerging hybrid imaging technology, MR-PET. The MR-PET scanner simultaneously acquires structural MR images and functional PET images. The work will provide clearer images without the effects of motion blur for both research and clinical applications.
Radiation detectors to better understand ion interactions. This project aims to build a Heavy Ion Therapy Research and Treatment Centre in Australia. Understanding how ions interact with matter and their radiobiological effectiveness (RBE) is important. The project will introduce an Australian detector technology platform to research ion interaction physics and their RBE. It will develop radiation detectors for ion measurement with a wide energy range, including a practical RBE quality assurance ....Radiation detectors to better understand ion interactions. This project aims to build a Heavy Ion Therapy Research and Treatment Centre in Australia. Understanding how ions interact with matter and their radiobiological effectiveness (RBE) is important. The project will introduce an Australian detector technology platform to research ion interaction physics and their RBE. It will develop radiation detectors for ion measurement with a wide energy range, including a practical RBE quality assurance tool with submillimetre spatial resolution. The proposed Australian radiation detection technology is expected to improve understanding of the scientific mechanisms underpinning the radiobiological effectiveness of heavy ion radiation.Read moreRead less
Spatiotemporal dynamics and analysis of functional magnetic resonance imaging. Functional magnetic resonance imaging (fMRI) produces signals generated by brain activity in fine detail, but links between activity and images are poorly understood, posing a barrier to full use of the technology. Predictions from our new theory of such links will be made, tested experimentally and used to improve fMRI and discover new phenomena.
Development of Novel Two-dimensional Techniques for Magnetic Resonance In-vivo Spectroscopy. Body chemistry alters with functionality, pain, ageing and disease. These changes can be recorded by magnetic resonance (MR) spectroscopy (MRS) in vivo in a whole body MR scanner. When changes in chemistry can be recorded rapidly, and the individual species assigned, it will be possible to make a definitive diagnosis and in some cases allow the tailoring of treatment on an individual basis. This is curre ....Development of Novel Two-dimensional Techniques for Magnetic Resonance In-vivo Spectroscopy. Body chemistry alters with functionality, pain, ageing and disease. These changes can be recorded by magnetic resonance (MR) spectroscopy (MRS) in vivo in a whole body MR scanner. When changes in chemistry can be recorded rapidly, and the individual species assigned, it will be possible to make a definitive diagnosis and in some cases allow the tailoring of treatment on an individual basis. This is currently hampered by our inability to separate the composite resonances in a one dimensional MR spectrum. Research will allow two dimensional MRS to be implemented and provide detailed chemical information on human organs in vivo. Read moreRead less