Periodic nano-ratchets: a new paradigm for biomolecule separation. This project proposes the theoretical and experimental study of a new separation principle. The platform technologies developed from this research will see wide ranging applications. They will reveal new insights into fundamental phenomena of membranes and separation processes underpinning development of new generation of separation technologies. New membranes and microchip separation devices which can be applied to genomic, prot ....Periodic nano-ratchets: a new paradigm for biomolecule separation. This project proposes the theoretical and experimental study of a new separation principle. The platform technologies developed from this research will see wide ranging applications. They will reveal new insights into fundamental phenomena of membranes and separation processes underpinning development of new generation of separation technologies. New membranes and microchip separation devices which can be applied to genomic, proteomic, forensic and a range medical, biotechnological and analytical applications will be readily achievable. This is an international and interdisciplinary research project and its outcomes will enhance Australia's ability in frontier technologies, advanced materials.Read moreRead less
Selective enrichment of proteins using micro-Gradiflow technology and characterisation of proteins using LC-MS/MS. This project describes crucial areas for the technology development of protein enrichment and fractionation. While current techniques are powerful, the usefulness to identify and characterise proteins of low abundance from massively complex samples in the presence of abundant proteins is limited and requires up to mililitre volumes. We intend to develop the micro-Gradiflow technolog ....Selective enrichment of proteins using micro-Gradiflow technology and characterisation of proteins using LC-MS/MS. This project describes crucial areas for the technology development of protein enrichment and fractionation. While current techniques are powerful, the usefulness to identify and characterise proteins of low abundance from massively complex samples in the presence of abundant proteins is limited and requires up to mililitre volumes. We intend to develop the micro-Gradiflow technology in association with Gradipore as a means of protein fractionation using microlitre volumes of sample. This technology will be applicable to all areas of proteomic research and in particular to the study of cell differentiation. The outcome for Australian industry, our competitiveness both industrial and scientific, and the potential for economic advancement is tremendous.Read moreRead less