A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Modular microfluidic platform for mimicking multi-organ system interactions. This project aims to develop a novel, modular microfluidic platform that overcomes current limitations of integrated systems in synchronising multi-tissue culture, imaging and operational complexity. Understanding multi-organ systemic crosstalk in human health and diseases demands dynamic culture systems that can mimic such interactions. This project will deliver a first-in-class platform technology and establish intern ....Modular microfluidic platform for mimicking multi-organ system interactions. This project aims to develop a novel, modular microfluidic platform that overcomes current limitations of integrated systems in synchronising multi-tissue culture, imaging and operational complexity. Understanding multi-organ systemic crosstalk in human health and diseases demands dynamic culture systems that can mimic such interactions. This project will deliver a first-in-class platform technology and establish international and disciplinary collaborations to develop different tissue and engineering modules relevant to applications in systemic nanotoxicology, drug bioactivation and chronic diseases. This will provide the cornerstone technology to develop a new generation of disease models and therapeutics targeting interaction dysfunctions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100692
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Multiphysics inertial microfluidics: from fundamentals to applications. Separation of particles and particularly cells is an indispensable process in disease diagnostics, chemical/biological assays and food/chemical industries. This project aims to study the interplay between inertial fluid flow, electricity, and magnetism in microscale for particle separation. The project is expected to establish the fundamental theory underpinning the development of the proposed advanced separation technology. ....Multiphysics inertial microfluidics: from fundamentals to applications. Separation of particles and particularly cells is an indispensable process in disease diagnostics, chemical/biological assays and food/chemical industries. This project aims to study the interplay between inertial fluid flow, electricity, and magnetism in microscale for particle separation. The project is expected to establish the fundamental theory underpinning the development of the proposed advanced separation technology. This disruptive technology is expected to enable the unique, high-performance and high-throughput separation of particles such as cells. The technology will potentially benefit the biomedical and pharmaceutical industries, providing economic opportunities and maintaining high-quality healthcare for Australia.Read moreRead less
Towards high-performance wearable devices: materials and microfabrication. This project aims to design and develop functional nanomaterials and nanocomposites for high-performance wearable tactile sensors, integrating the sensors with nanogenerator and charge storage devices. In addition to the functional materials approach, precise control of device architecture through additive manufacturing and laser patterning will be implemented to maximise device performance. The expected outcomes of this ....Towards high-performance wearable devices: materials and microfabrication. This project aims to design and develop functional nanomaterials and nanocomposites for high-performance wearable tactile sensors, integrating the sensors with nanogenerator and charge storage devices. In addition to the functional materials approach, precise control of device architecture through additive manufacturing and laser patterning will be implemented to maximise device performance. The expected outcomes of this project include the detailed understanding of the nanomaterials structural-property relationship under constant mechanical stresses and establishing fundamental principle on the microfabrication of nano device wearable devices. This project will advance the field of materials chemistry and advanced manufacturing with niche high value-added products.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100205
Funder
Australian Research Council
Funding Amount
$433,000.00
Summary
Engineering micropatterned surfaces for cell mechanics and mechanobiology. This project aims to engineer a highly versatile micropatterned surface that can be used to culture and study cells. This project expects to generate a unique microtechnology, as well as new knowledge in surface science and cell mechanics by elucidating the relationship between controlled surface wettability and cell behaviour. The expected outcomes of this project include a low-cost and highly engineered tissue culture t ....Engineering micropatterned surfaces for cell mechanics and mechanobiology. This project aims to engineer a highly versatile micropatterned surface that can be used to culture and study cells. This project expects to generate a unique microtechnology, as well as new knowledge in surface science and cell mechanics by elucidating the relationship between controlled surface wettability and cell behaviour. The expected outcomes of this project include a low-cost and highly engineered tissue culture tool that controls cellular functions, revolutionising practices in stem cell engineering. The platform technology has a great potential for commercialisation and enhancing Australian research capacity through international and interdisciplinary collaborations and will directly benefit the Australian biotech industry.Read moreRead less
Microfluidics with core-shell beads: handling liquids like solids. Reducing waste of consumables in chemical reactions promises to solve environmental problems as well as enable novel applications in space. This project aims to establish a revolutionary fluid handling technology that lowers waste in the labs and in satellites. The project deciphers the fundamental physics behind our recent discovery of encapsulating a tiny liquid content in a solid shell, allowing for handling liquid samples lik ....Microfluidics with core-shell beads: handling liquids like solids. Reducing waste of consumables in chemical reactions promises to solve environmental problems as well as enable novel applications in space. This project aims to establish a revolutionary fluid handling technology that lowers waste in the labs and in satellites. The project deciphers the fundamental physics behind our recent discovery of encapsulating a tiny liquid content in a solid shell, allowing for handling liquid samples like solid particles. Examples of the benefit of this project are more precise detection of bacteria on earth and compact reactors in space. The research outcomes are instrumental for promoting a clean environment, good health, and creating new business opportunities, particularly in space industry, for Australians.Read moreRead less