Smart affinity membranes for manufacture of high value therapeutic proteins. This project aims to develop next generation separation membranes for production of high-value proteins from serum. Through a combination of innovative chemistries, biotechnology and engineering, the project will enhance production, efficiency and resolution of membranes for separating complex mixtures, thereby contributing to broader understanding in membrane science. By establishing a strong collaborative link between ....Smart affinity membranes for manufacture of high value therapeutic proteins. This project aims to develop next generation separation membranes for production of high-value proteins from serum. Through a combination of innovative chemistries, biotechnology and engineering, the project will enhance production, efficiency and resolution of membranes for separating complex mixtures, thereby contributing to broader understanding in membrane science. By establishing a strong collaborative link between academic and industry researchers, this project has the potential to significantly value-add to existing and exciting Australian technology by enhancing the efficiency of plasma fractionation, improving isolation of large molecules from complex media and by improving the downstream manufacturing and bioprocessing pipeline. Read moreRead less
Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation o ....Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation of nanomaterials with antibodies. This project has the potential to rapidly improve the ligation process between synthetic nanomaterials and biologics, leading to more efficient synthesis of targeted diagnostics. This would provide a significant commercial advantage for any nanomaterials developed for the field, and specifically for this project, expedite translation of MIL38.Read moreRead less
Development of dense gas technology platforms for the formulation of oral vaccines. This project will aim to develop a technology platform that enables the formulation of vaccines that can be delivered orally and this research has the potential to radically change existing vaccination regimens. The availability of needle-free vaccination also has potential for considerable societal and economic impact in developing countries.
Designer Nanoparticles Enable mRNA Protein Factories. Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestio ....Designer Nanoparticles Enable mRNA Protein Factories. Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestion and thermal stress. This will be achieved by tailoring the nanochemistry at multi-scales. Expected outcomes include new knowledge in custom-design of functional nanomaterials for mRNA delivery, and new technology that will bring commercial benefits to the partner organisation and the biopharma sector.Read moreRead less