Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation o ....Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation of nanomaterials with antibodies. This project has the potential to rapidly improve the ligation process between synthetic nanomaterials and biologics, leading to more efficient synthesis of targeted diagnostics. This would provide a significant commercial advantage for any nanomaterials developed for the field, and specifically for this project, expedite translation of MIL38.Read moreRead less
Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and ....Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and their consequent integration under physiological conditions. This project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community at the cutting edge of science. The project will also deliver intellectual property, which will position Australia at the forefront of bionanotechnology.Read moreRead less
Biomimetic Design and Fabrication of Smart Dry Adhesives. Gecko footpads have unique structures with amazing features; imitating these fine bio-structures will lead to a multitude of innovations. This project aims to study fundamental principles governing adhesion phenomena for creating entirely new biomimetic nanomaterials with tunable adhesion, self-cleaning and controlled release capabilities. The gecko-mimicking materials and the associated dynamic effects will be characterized quantitativel ....Biomimetic Design and Fabrication of Smart Dry Adhesives. Gecko footpads have unique structures with amazing features; imitating these fine bio-structures will lead to a multitude of innovations. This project aims to study fundamental principles governing adhesion phenomena for creating entirely new biomimetic nanomaterials with tunable adhesion, self-cleaning and controlled release capabilities. The gecko-mimicking materials and the associated dynamic effects will be characterized quantitatively at multiscales and the nanoscale phenomena will be linked to macroscopic performance. The results of this research should provide a fundamental understanding of tunable adhesion mechanisms for the design and development of optimized materials with superb performance of practical significance.
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