Fine control of nucleic acid transport using cyclic peptide nanotubes. This project aims to develop new technology to enhance the transport of nucleic acids (DNA or RNA) across biological membranes, and to facilitate the delivery of nucleic acids into mammalian cells. Elaborate transport mechanisms have emerged by evolution of viruses but the use of viruses for therapeutic purposes presents safety challenges. This project aims to enhance the efficiency of synthetic nucleic acid delivery system ....Fine control of nucleic acid transport using cyclic peptide nanotubes. This project aims to develop new technology to enhance the transport of nucleic acids (DNA or RNA) across biological membranes, and to facilitate the delivery of nucleic acids into mammalian cells. Elaborate transport mechanisms have emerged by evolution of viruses but the use of viruses for therapeutic purposes presents safety challenges. This project aims to enhance the efficiency of synthetic nucleic acid delivery systems, making use of novel biocompatible materials which assemble into controlled three-dimensional structures, offering more control over membrane interactions. The project is expected to provide a new platform of smart materials which could be developed for biomedical applications in the future.Read moreRead less
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less