Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expe ....Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expected outcomes of this project include enhanced national capacity in disruptive wearable bioelectronics, strengthening international collaborations, unskilled workforce training, as well as advancement of Australian knowledge base in the fields of nanotechnology, materials science, energy, biosensors and bioelectronics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101666
Funder
Australian Research Council
Funding Amount
$395,588.00
Summary
Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properti ....Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properties. Expected outcomes include a family of adhesive nanoparticles designed for nanopesticide and animal feed applications, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technology advancement.Read moreRead less
Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in c ....Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in cellular pathways. Expected outcomes include a universal technology platform to detect single molecules in single cells, with potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.Read moreRead less
Soft Plasmene Nanosheets for Stretchable Plasmonic Skins. Conventional plasmonic sensors and devices are rigid, planar, and not stretchable. This project aims to apply plasmene materials developed at Monash's Nanobionics lab to design highly stretchable plasmonic devices (artificial plasmonic skins). Systematic experimental and theoretical studies will be undertaken to understand how the plasmonic skins respond to strains and how they can be used for fabricating novel stretchable devices. Such s ....Soft Plasmene Nanosheets for Stretchable Plasmonic Skins. Conventional plasmonic sensors and devices are rigid, planar, and not stretchable. This project aims to apply plasmene materials developed at Monash's Nanobionics lab to design highly stretchable plasmonic devices (artificial plasmonic skins). Systematic experimental and theoretical studies will be undertaken to understand how the plasmonic skins respond to strains and how they can be used for fabricating novel stretchable devices. Such studies will generate important new knowledge of fabrication, characterisation, and modelling of stretchable plasmene, hence, contributing to further Australian standing in the field of nanotechnology and plasmonics. It may also incubate patentable technologies, bringing potential economic gains.Read moreRead less
Impact of Biological Coatings on Nanoparticle–Immune Cell Interactions. Nanomaterials exposed to biological environments such as blood or lymph fluids rapidly adsorb a layer of biomolecules on their surface, forming a biomolecular corona, and profoundly altering their properties. This project aims to resolve the influence of biomolecular coronas on nanoparticle–immune cell interactions by combining particle engineering, immunology, proteomics and bioinformatic analysis. The project expected outc ....Impact of Biological Coatings on Nanoparticle–Immune Cell Interactions. Nanomaterials exposed to biological environments such as blood or lymph fluids rapidly adsorb a layer of biomolecules on their surface, forming a biomolecular corona, and profoundly altering their properties. This project aims to resolve the influence of biomolecular coronas on nanoparticle–immune cell interactions by combining particle engineering, immunology, proteomics and bioinformatic analysis. The project expected outcomes are to generate new knowledge in nanomaterial–immune cell behaviour and design principles for nanoparticles with prospective applications in the agricultural, veterinary and biomedical sectors.Read moreRead less
Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly t ....Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly technology, new knowledge of cell-nanomaterial interactions and new design principles for nanoparticles with potential future applications in drug delivery, immunology and nanomedicine. This project should provide significant benefits to polymer, nanomaterial and pharmaceutical research and industry in Australia.Read moreRead less
Bioengineering self-assembly of innovative core-shell nanomaterials . This project aims to generate new knowledge in nanoscale bioengineering. It expects to develop a disruptive platform technology for design and manufacture of advanced nanomaterials to provide solutions for unmet needs in industry. It will explore an innovative bioengineering concept that merges biopolymer synthesis with virus-like particle self-assembly to produce innovative tunable core-shell nanomaterials. Expected outcomes ....Bioengineering self-assembly of innovative core-shell nanomaterials . This project aims to generate new knowledge in nanoscale bioengineering. It expects to develop a disruptive platform technology for design and manufacture of advanced nanomaterials to provide solutions for unmet needs in industry. It will explore an innovative bioengineering concept that merges biopolymer synthesis with virus-like particle self-assembly to produce innovative tunable core-shell nanomaterials. Expected outcomes are the development of advanced techniques for design and manufacture of innovate nanomaterials with enhanced stability and performance. This innovative platform technology for precision engineering of high-performance nanomaterials should provide significant benefits for biotechnological and agricultural industries.Read moreRead less
Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions ....Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions. Single cell scale will greatly improve detection accuracy for heterogeneous cell populations. Benefits will include new knowledge of cell-to-cell communication and intellectual property in manufacturing, which will foster collaborations across institutions and Australian industry by providing new technological solutions.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100180
Funder
Australian Research Council
Funding Amount
$2,781,000.00
Summary
Upconversion nanophotonic systems . The photon upconversion process can produce visible light from lower-energy near-infrared incident light. This Laureate Program aims to address major bottlenecks in upconversion nanotechnology – the efficiency, stability and absorption bandwidth. Expected outcomes include new knowledge in the interface design of hybrid materials, a world-leading single-particle spectroscopy system, a new family of molecular probes, and novel super-resolution microscopy for fun ....Upconversion nanophotonic systems . The photon upconversion process can produce visible light from lower-energy near-infrared incident light. This Laureate Program aims to address major bottlenecks in upconversion nanotechnology – the efficiency, stability and absorption bandwidth. Expected outcomes include new knowledge in the interface design of hybrid materials, a world-leading single-particle spectroscopy system, a new family of molecular probes, and novel super-resolution microscopy for functional imaging of subcellular organelles. This research offers exciting opportunities for single-molecule tracking, quantitative diagnostics, non-invasive imaging, bio-mechanical force measurement and thermometry; tools to observe the nanoscale world inside live cells.Read moreRead less
Next-generation epigenetic analysis: direct reading of DNA methylation. This project aims to develop a new molecular tool to directly and dynamically read chemical modifications on genomic DNA (epigenetics) by utilizing advanced nanomaterials with the unique features of Raman spectroscopy. Epigenetics affects cellular processes and controls genetic programs by turning them “on” and “off" but there is currently no direct method to measure modifications on DNA. A new technology will be designed to ....Next-generation epigenetic analysis: direct reading of DNA methylation. This project aims to develop a new molecular tool to directly and dynamically read chemical modifications on genomic DNA (epigenetics) by utilizing advanced nanomaterials with the unique features of Raman spectroscopy. Epigenetics affects cellular processes and controls genetic programs by turning them “on” and “off" but there is currently no direct method to measure modifications on DNA. A new technology will be designed to avoid complicated procedures/chemistry for DNA epigenetic analysis providing a specific molecular fingerprint. The anticipated outcomes include a new technique and advanced knowledge in nanomaterials and DNA functions, thus strengthening the economic viability of Australian manufacturing and biotechnology sectors.Read moreRead less