Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will ex ....Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework for exploring and validating genetic regulatory models in general. This will be used on an exemplar application for understanding the induction process in lambda phage.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101842
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
New mathematical models for capturing heterogeneity of human brain tissue. This project aims to understand the impact of the heterogeneity of brain tissue on Magnetic Resonance Imaging (MRI) data in both healthy and diseased human brains, and to extract and quantify information on heterogeneity from the data. The project aims to develop novel mathematical and computational approaches to model the heterogeneity of the human brain. The project aims to identify new biomarkers for classifying differ ....New mathematical models for capturing heterogeneity of human brain tissue. This project aims to understand the impact of the heterogeneity of brain tissue on Magnetic Resonance Imaging (MRI) data in both healthy and diseased human brains, and to extract and quantify information on heterogeneity from the data. The project aims to develop novel mathematical and computational approaches to model the heterogeneity of the human brain. The project aims to identify new biomarkers for classifying different brain diseases, based on the extent of heterogeneity across different brain tissue. Results will be validated against extensive MRI scanning data of patients. This project aims to advance state-of-the-art techniques in human brain MRI data analysis.Read moreRead less
Discovery Indigenous Researchers Development - Grant ID: DI0453648
Funder
Australian Research Council
Funding Amount
$144,184.00
Summary
Modelling of coupled heat and water flow through layered soils with an extension to heat flow through granulated soils. The main aim of this project is to develop a mathematical model to simulate coupled heat and water flow through layered soils. The coupling of the two processes will allow us to examine the interaction between heat and water flow. The project also aims to extend the heat component of the flow model to granulated heterogeneous soils by developing a model that encapsulates heat e ....Modelling of coupled heat and water flow through layered soils with an extension to heat flow through granulated soils. The main aim of this project is to develop a mathematical model to simulate coupled heat and water flow through layered soils. The coupling of the two processes will allow us to examine the interaction between heat and water flow. The project also aims to extend the heat component of the flow model to granulated heterogeneous soils by developing a model that encapsulates heat effects at the microscopic and macroscopic level. The model will be applied to two problems 1) hydraulic barriers in cover liner designs for landfills and 2) assessing the ability of heat sensors to measure various soil properties under field conditions.Read moreRead less
A multi-scale approach for modelling coupled transport in heterogeneous and anisotropic porous media. Mathematical Sciences foster interdisciplinary collaboration and underpin fundamental understanding of significant national/international research priorities in science and technology. This world-class team will advance knowledge in modelling complex systems ensuring the competitiveness of Australian research in this important field. A key outcome is a multi-scale computational strategy that can ....A multi-scale approach for modelling coupled transport in heterogeneous and anisotropic porous media. Mathematical Sciences foster interdisciplinary collaboration and underpin fundamental understanding of significant national/international research priorities in science and technology. This world-class team will advance knowledge in modelling complex systems ensuring the competitiveness of Australian research in this important field. A key outcome is a multi-scale computational strategy that can be used by engineers in Australia and France to simulate transport phenomena in porous media, which have significant environmental impact. The research will lead to publications in scientific journals and communications at national/international conferences. Research training of postdocs and PhD students is another excellent outcome of the project.Read moreRead less
A unifying framework for generalised distributed-order fractional models. This project aims to develop a unifying theoretical framework for generalised fractional models using measure theory and a new class of distributed-order nonlocal operators to simulate anomalous transport processes in heterogeneous and anisotropic porous media. The project expects to generate a mathematical foundation for fractional modelling and clarity on the role of, and relationship between, the many variants of fracti ....A unifying framework for generalised distributed-order fractional models. This project aims to develop a unifying theoretical framework for generalised fractional models using measure theory and a new class of distributed-order nonlocal operators to simulate anomalous transport processes in heterogeneous and anisotropic porous media. The project expects to generate a mathematical foundation for fractional modelling and clarity on the role of, and relationship between, the many variants of fractional operators used in modern practice and how to impose boundary conditions on finite domains. Expected outcomes of the project include an evaluation of dimensionality and/or complexity reduction of the governing equations in fractional transport models with a focus on groundwater applications.Read moreRead less
From genes to organ function: understanding how heterogeneity in tissue modulates cellular behaviour in the heart. New computational and software engineering approaches are developed to model the electrophysiological variability of the heart and the mechanisms inducing arrhythmias. A significant outcome is a set of practical tools vital to cardiac research that provide medical specialists the ability to test hypotheses on low-cost powerful computing hardware.
Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in ....Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101398
Funder
Australian Research Council
Funding Amount
$355,744.00
Summary
Quantifying the risk of groundwater contamination from hydraulic fracturing in coal seam gas operations in Australia. Concern for impacts to groundwater resources due to coal seam gas operations has led to heated debate in the community. This project will assess the risk to groundwater contamination from fracking in coal seam gas operations. It is critical that naturally occurring compounds in the coal seam and injected compounds are not mobilised to aquifers topped by water bores. This project ....Quantifying the risk of groundwater contamination from hydraulic fracturing in coal seam gas operations in Australia. Concern for impacts to groundwater resources due to coal seam gas operations has led to heated debate in the community. This project will assess the risk to groundwater contamination from fracking in coal seam gas operations. It is critical that naturally occurring compounds in the coal seam and injected compounds are not mobilised to aquifers topped by water bores. This project will build accurate, site-specific, dynamic numerical models of the hydraulic-fracturing process in coal seam gas operations. This will enable prediction of the maximum vertical extent of stimulated fractures in specific coal seams and will help establish criteria for when and where fracking in coal seam gas wells is safe in relation to groundwater contamination.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101137
Funder
Australian Research Council
Funding Amount
$312,000.00
Summary
Two-scale numerical modelling of coupled transport in heterogeneous media. Groundwater constitutes a vital part of water resources in Australia, however, the quality of this water is susceptible to contamination. This project aims to develop an innovative two-scale mathematical model for contaminant transport that accounts for small-scale heterogeneities found in the unsaturated zone of an aquifer located between the ground surface and the underlying groundwater. The project aims to develop valu ....Two-scale numerical modelling of coupled transport in heterogeneous media. Groundwater constitutes a vital part of water resources in Australia, however, the quality of this water is susceptible to contamination. This project aims to develop an innovative two-scale mathematical model for contaminant transport that accounts for small-scale heterogeneities found in the unsaturated zone of an aquifer located between the ground surface and the underlying groundwater. The project aims to develop valuable environmental insights, a simulation tool that will help in making decisions regarding the future management of Australian groundwater resources, and a general two-scale modelling and simulation framework for other important environmental and industrial problems involving coupled transport in heterogeneous media.Read moreRead less
Image-based Multiscale Modelling of Transport Phenomena in Porous Media. This project aims to develop an innovative general framework to build multiphase porous media transport models directly from electron microscope images of the underlying microstructure. Leading edge experimental, computational and applied mathematical techniques are proposed to drive this novel approach of multiscale modelling, employable across numerous fields of science and engineering. The central project theme of develo ....Image-based Multiscale Modelling of Transport Phenomena in Porous Media. This project aims to develop an innovative general framework to build multiphase porous media transport models directly from electron microscope images of the underlying microstructure. Leading edge experimental, computational and applied mathematical techniques are proposed to drive this novel approach of multiscale modelling, employable across numerous fields of science and engineering. The central project theme of developing an efficient and accurate multiscale model for simulating transport in heterogeneous porous media is expected to find application in the drying, timber and crop industries, and governmental agencies managing pollution in groundwater resources. This insight is likely to be invaluable for designing new industrial technologies and optimising current operations.Read moreRead less