Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules ....Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules being sought in the development of new therapeutic agents and/or materials. The combined application of molecular biological, microbiological and chemical synthesis techniques in a concerted manner in the one location will lead to a raft of new opportunities for the biotech and pharmaceutical industries in Australia.Read moreRead less
ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment ....ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment of several life-threatening conditions such as stroke. Industrial applications include better surface coatings for preserving metals, and additives to improve the quality and shelf life of beer and wines.Read moreRead less
The chemical, biochemical, genetic and ecological basis of pollinator-driven speciation in Australian sexually deceptive orchids. The Australian biota offers unique opportunities for illuminating ecological and evolutionary processes of worldwide importance. Focussing on Australian sexually deceptive orchids, this study offers a model system for studies of plant speciation that has already captured the interest of the public, educators and scientists around the world. The project will produce mu ....The chemical, biochemical, genetic and ecological basis of pollinator-driven speciation in Australian sexually deceptive orchids. The Australian biota offers unique opportunities for illuminating ecological and evolutionary processes of worldwide importance. Focussing on Australian sexually deceptive orchids, this study offers a model system for studies of plant speciation that has already captured the interest of the public, educators and scientists around the world. The project will produce multiple graduate students with high quality, cross-disciplinary training. Expertise and tools developed will contribute directly to the conservation of endangered Australian orchids. Thus the knowledge obtained from this research will have immediate practical benefits for the sustainable use of Australia's biodiversity.Read moreRead less
Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules ....Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules being sought in the development of new therapeutic agents and/or materials. The combined application of molecular biological, microbiological and chemical synthesis techniques in a concerted manner in the one location will lead to a raft of new opportunities for the biotech and pharmaceutical industries in Australia. Read moreRead less
In-field sensors for the detection of illicit drugs. Presumptive field test kits for illicit drugs analysis are typically based on chemical spot tests that produce a coloured product. While relatively easy to apply, such test kits (containing wet chemicals) produce inconclusive colour changes lacking sensitivity, and selectivity requiring a subjective assessment by the examiner. Despite these limitations, these test kits are in widespread use and are routinely used. This study aims to develop s ....In-field sensors for the detection of illicit drugs. Presumptive field test kits for illicit drugs analysis are typically based on chemical spot tests that produce a coloured product. While relatively easy to apply, such test kits (containing wet chemicals) produce inconclusive colour changes lacking sensitivity, and selectivity requiring a subjective assessment by the examiner. Despite these limitations, these test kits are in widespread use and are routinely used. This study aims to develop specific in-field sensors for the detection and identification of illicit drugs. This would significantly enhance the ability of Forensic Services staff to confirm the identity of seized material. Increased specificity would provide valuable early advice to investigators regarding the nature of a seizure and would reduce the likelihood of false positive results. Increased sensitivity would permit the analysis of trace amounts of material from individuals or locations related to an illicit drug consignment.Read moreRead less
gem-Dihalogenocyclopropanes as building blocks for the chemical synthesis of biologically active natural products and their analogues. New and efficient methods for the assembly of biologically active compounds will emerge from this research and thus provide materials for evaluation as potential therapeutics in the treatment of a range of pathological conditions including Alzheimer's disease and certain types of lung cancers that respond poorly to currently available treatments. The underpinning ....gem-Dihalogenocyclopropanes as building blocks for the chemical synthesis of biologically active natural products and their analogues. New and efficient methods for the assembly of biologically active compounds will emerge from this research and thus provide materials for evaluation as potential therapeutics in the treatment of a range of pathological conditions including Alzheimer's disease and certain types of lung cancers that respond poorly to currently available treatments. The underpinning methodologies are also likely to provide opportunities in other areas, including materials science. The training of a highly capable post-doctoral in chemical synthesis, an area where there is now an extraordinary and unsatisfied demand for such expertise, will be a further benefit of the proposed program of research.Read moreRead less