Chemical proteomics: proteomics with no detection limit. Half of all drugs are derived from natural products, yet little is known about how most achieve their therapeutic action. This project aims to develop a methodology to rapidly uncover drug-protein interactions and pave the way for faster drug development and a better understanding of drug action.
Overcoming antibiotic resistance: rapid discovery of new antibacterial drug targets using chemical proteomics. The prevalence of multidrug-resistant bacteria in the community is a critical public health issue and there is an urgent and compelling need for new antibiotics with novel modes of action to combat these deadly superbugs. While antibiotics from nature have long been a mainstay of the pharmaceutical industry, their development as drugs can be challenging as their cellular targets and mod ....Overcoming antibiotic resistance: rapid discovery of new antibacterial drug targets using chemical proteomics. The prevalence of multidrug-resistant bacteria in the community is a critical public health issue and there is an urgent and compelling need for new antibiotics with novel modes of action to combat these deadly superbugs. While antibiotics from nature have long been a mainstay of the pharmaceutical industry, their development as drugs can be challenging as their cellular targets and modes of action are frequently unknown. In this project, innovative chemical proteomics approaches will be used to rapidly identify and characterise the cellular targets and modes of action of both newly discovered and historic antibiotic natural products, thereby overcoming this bottleneck and accelerating the development of next-generation antibiotics.Read moreRead less
Genetic code expansion of a eukaryotic in vitro translation system. The genetic code programs biosynthesis of polypeptides with efficiency vastly superior to chemical engineering. As the chemical diversity of natural amino acids in proteins is limited, finding ways to include “unnatural” amino acids can supercharge biology with a range of new protein activities. While the genetic code can be expanded to make space for unnatural amino acids, the rarity of free codons and reliance on prokaryotic ....Genetic code expansion of a eukaryotic in vitro translation system. The genetic code programs biosynthesis of polypeptides with efficiency vastly superior to chemical engineering. As the chemical diversity of natural amino acids in proteins is limited, finding ways to include “unnatural” amino acids can supercharge biology with a range of new protein activities. While the genetic code can be expanded to make space for unnatural amino acids, the rarity of free codons and reliance on prokaryotic organisms limit the applicability of this approach. We will develop a new higher-organism cell-free protein production system that can incorporate multiple unnatural amino acids into defined points of proteins. This, enabling and broadly applicable technology, will be tested by constructing opioid biosensors.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100082
Funder
Australian Research Council
Funding Amount
$120,000.00
Summary
Ultraviolet laser system (193 nanometres). New grating and integrated component technologies—many of which were pioneered in Australia at the existing facility—are revolutionising the role of photonics in disciplines outside of telecommunications. From ultra-high temperature fibre gratings for both the energy and mining industries and high power fibre lasers, through to the processing of substrates to pattern chemical attachment of self-assembled structures, and novel quantum processing approach ....Ultraviolet laser system (193 nanometres). New grating and integrated component technologies—many of which were pioneered in Australia at the existing facility—are revolutionising the role of photonics in disciplines outside of telecommunications. From ultra-high temperature fibre gratings for both the energy and mining industries and high power fibre lasers, through to the processing of substrates to pattern chemical attachment of self-assembled structures, and novel quantum processing approaches, new research areas are emerging. 193nm laser processing remains central to all these technologies. This facility will continue to keep Australia at the forefront of such research underpinning this next generation of technologies.Read moreRead less