A nanoengineered solution to drug delivery in bone. This project presents an exciting new approach of applying nanotechnology to bone research. By combining our expertise in nanoengineering of new materials, mathematical modelling and bone biology, this project will result in a well-characterised model for drug delivery into bone and lead to a new therapeutic approach for treating bone diseases.
Material structure and properties of mineralised tissue: An integrated micro and nano level investigation. Bone material properties have a direct influence on disorders of the skeleton, such as osteoporotic bone fragility fractures and osteoarthritis. It has been estimated that the direct and indirect cost of all fragility fractures and arthritis is over $20 billion per annum. The impact of this will be far-reaching with the social benefits ranging from earlier and more accurate diagnoses, to t ....Material structure and properties of mineralised tissue: An integrated micro and nano level investigation. Bone material properties have a direct influence on disorders of the skeleton, such as osteoporotic bone fragility fractures and osteoarthritis. It has been estimated that the direct and indirect cost of all fragility fractures and arthritis is over $20 billion per annum. The impact of this will be far-reaching with the social benefits ranging from earlier and more accurate diagnoses, to the development of preventative strategies to delay the onset of musculoskeletal disorders. These developments will translate into exciting commercial opportunities and overall economic growth and sustainability.Read moreRead less
Three-dimensional Simulation of Trabecular Bone Remodelling. Nearly 2 million Australians currently suffer from osteoporosis. Statistics indicate that 25% of Australian women and 17% of men will develop an osteoporotic fracture. The cost of osteoporosis is $7.4 billion per annum; the numbers of affected individuals and costs are expected to continue increasing. Clearly, improvements to osteoporosis diagnosis, fracture risk assessment, and effective treatments are still urgently needed. The p ....Three-dimensional Simulation of Trabecular Bone Remodelling. Nearly 2 million Australians currently suffer from osteoporosis. Statistics indicate that 25% of Australian women and 17% of men will develop an osteoporotic fracture. The cost of osteoporosis is $7.4 billion per annum; the numbers of affected individuals and costs are expected to continue increasing. Clearly, improvements to osteoporosis diagnosis, fracture risk assessment, and effective treatments are still urgently needed. The proposed project aims to create a tool for understanding the mechanisms of bone loss and predicting the effects of osteoporosis therapies. It represents a solid contribution to the knowledge base necessary for advancing osteoporosis research and ultimately reducing the incidence of osteoporotic fracture.Read moreRead less