Synthetic and theoretical studies of metal complexes containing carbon-rich ligands. Previous studies in my group, in conjunction with synthetic and theoretical chemistry groups at the Université de Rennes 1, France, have delineated the properties of a series of complexes containing carbon chains linking two metal centres. Having achieved a partial understanding of the features which result in good electronic communication between the metal centres via the carbon chain, the present proposal see ....Synthetic and theoretical studies of metal complexes containing carbon-rich ligands. Previous studies in my group, in conjunction with synthetic and theoretical chemistry groups at the Université de Rennes 1, France, have delineated the properties of a series of complexes containing carbon chains linking two metal centres. Having achieved a partial understanding of the features which result in good electronic communication between the metal centres via the carbon chain, the present proposal seeks to extend this collaboration to further studies which will generate related compounds in which actual eletron exchange can occur, i.e. leading to oxidation/reduction, by using compounds in which two or more different metal centres are present. This may lead to development of nano devices, e.g. molecular-scale switches. If one of the centres is activated by light, a photo-active sensor may result.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100129
Funder
Australian Research Council
Funding Amount
$249,000.00
Summary
Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution ma ....Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution mass spectrometer is fundamental to extend our research capabilities to new environmental contaminants and environmental exposure biomarkers, as well as consumption biomarkers of new illicit drugs and their metabolites. This instrument will fill an important gap in our capacity to link health/ecological risk to unknown chemicals and will allow interdisciplinary researchers to advance work in environmental toxicology, chemistry and forensics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100381
Funder
Australian Research Council
Funding Amount
$444,000.00
Summary
Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australi ....Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australia and internationally by aiding development of early warning drug monitoring systems, providing the rapid deployment of interventions to reduce drug-related harm in the local community, while facilitating law and government agencies to better direct resources.Read moreRead less
Towards a Molecular-Scale Understanding of Sorption of Organic Pollutants to Soil. The toxicity, mobility and persistence of organic pollutants in soils are in large part controlled by their sorption to soil organic matter. The chemical nature or quality of the organic matter affects not only the amount of chemical sorbed, but also the reversibility of sorption and the rate of sorption and desorption. Until now, only bulk measures of soil organic matter chemistry have been considered in sorption ....Towards a Molecular-Scale Understanding of Sorption of Organic Pollutants to Soil. The toxicity, mobility and persistence of organic pollutants in soils are in large part controlled by their sorption to soil organic matter. The chemical nature or quality of the organic matter affects not only the amount of chemical sorbed, but also the reversibility of sorption and the rate of sorption and desorption. Until now, only bulk measures of soil organic matter chemistry have been considered in sorption studies. This project introduces novel spectroscopic techniques that for the first time identify the chemical environment of sorbed molecules at the molecular scale. This will enable better prediction of pollutant transport and degradation.Read moreRead less
Universal immunogenic reagents for the detection of latent fingermarks. This project will deliver the first antibody reagents for the routine detection of natural fingermarks. This will assist law enforcement agencies to provide a safer society through improved crime clearance, as they will be able to enhance and detect fingermarks that otherwise remain undetected with current techniques (e.g. fingermarks on human skin).
Short- and long-term mitigation strategies for acid and metalliferous drainage control from iron ore mine wastes. Acid and metalliferous drainage from mine wastes, caused by oxidation of sulfide minerals, particularly pyrite, are a critical environmental issue worldwide. Although options to retard sulfide oxidation exist, including encapsulation methods, chemical additives and inhibition of iron-oxidising bacteria, these suffer from long-term instability. The project aims to investigate mechanis ....Short- and long-term mitigation strategies for acid and metalliferous drainage control from iron ore mine wastes. Acid and metalliferous drainage from mine wastes, caused by oxidation of sulfide minerals, particularly pyrite, are a critical environmental issue worldwide. Although options to retard sulfide oxidation exist, including encapsulation methods, chemical additives and inhibition of iron-oxidising bacteria, these suffer from long-term instability. The project aims to investigate mechanistic approaches, using readily available mineralogical materials, to provide passivating conditions resulting in slowed oxidation rates. The project’s focus is on treatments for wastes from iron ore deposits which are of high economic significance to Australia. The outcome aims to be a treatment ‘pathway’ enabling practical waste rock treatment over the acid forming time-profile.Read moreRead less
Long-term acid rock and tailings drainage mitigation through source control. Effective long-term management of acid rock drainage (ARD) from sulfidic mine wastes in current, exhausted and legacy mine sites is of critical importance to communities and for sustainable mining. An optimised geochemical and microbial multi-barrier approach to long-term reduction of ARD to environmentally acceptable rates will be developed by this project.
Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lip ....Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lipid biology at the cellular and sub-cellular level across a wide range of in vitro and in vivo models. The outcomes of this project should provide significant knowledge to tackle modern societal challenges in healthy ageing, brain pathologies and neurodegenerative diseases.Read moreRead less
Studies of metal compounds containing carbon chains - approaches to novel materials. There is an increasing need to design functional devices on the molecular scale ("nanotechnology"). We are developing the chemistry of compounds which contain chains of up to 12 carbon atoms to allow electronic communication between metal centres attached to each end. This projects seeks to extend this work, to discover new and more effective compounds, and to develop the associated chemistry to provide synthese ....Studies of metal compounds containing carbon chains - approaches to novel materials. There is an increasing need to design functional devices on the molecular scale ("nanotechnology"). We are developing the chemistry of compounds which contain chains of up to 12 carbon atoms to allow electronic communication between metal centres attached to each end. This projects seeks to extend this work, to discover new and more effective compounds, and to develop the associated chemistry to provide syntheses of novel compounds of potential use in the fine chemicals industry. Extensive collaboration with French colleagues exists and will continue.Read moreRead less
Mechanisms for Pyrite Oxidation Control in Acid Mine Drainage. The annual costs of acid rock drainage (ARD) management at operating sites in Australia are $120M p.a.; over 15 years, a total cost of $1.8 billion for the whole industry. There are limitations to the ability of existing systems to cope with high capacity ARD, to the long-term effectiveness of these systems and high potential costs/liability of remediation. The value of the project outcomes to industry and government will be in reduc ....Mechanisms for Pyrite Oxidation Control in Acid Mine Drainage. The annual costs of acid rock drainage (ARD) management at operating sites in Australia are $120M p.a.; over 15 years, a total cost of $1.8 billion for the whole industry. There are limitations to the ability of existing systems to cope with high capacity ARD, to the long-term effectiveness of these systems and high potential costs/liability of remediation. The value of the project outcomes to industry and government will be in reduction of ARD release, well-understood long-term outcomes, reduced cost of treatments and improved control. The scale of these savings is in the tens of $M p.a. but also in potential improvements in environment (acid and toxic metals in streams), health and social quality of life in mining areas and towns.Read moreRead less