Harnessing light and electricity to drive chemical synthesis. This project will explore and establish original strategies that use inputs of energy (light and electricity) to break or form chemical bonds, which can provide new or improved access to valuable compounds. In this way, this research will augment or enhance existing methods for the selective and direct manipulation of molecules by creating tools that allow chemists to prepare molecules under particularly mild conditions. The outcomes ....Harnessing light and electricity to drive chemical synthesis. This project will explore and establish original strategies that use inputs of energy (light and electricity) to break or form chemical bonds, which can provide new or improved access to valuable compounds. In this way, this research will augment or enhance existing methods for the selective and direct manipulation of molecules by creating tools that allow chemists to prepare molecules under particularly mild conditions. The outcomes of the project will include the development of new technology for organic synthesis and forging novel approaches for chemical alkylation and cross-coupling reactions. This can contribute to making important compounds more efficiently, safely and cheaper to produce in the future.Read moreRead less
Atmospheric Photothermal Oxidation as a New Reaction in the Atmosphere. Atmospheric models provide crucial advice on the current and future impacts of human activity on the atmosphere. This project hypothesizes the presence of a new class of chemical reactions that are unknown in atmospheric science and therefore missing from the best existing models. The reactions require both sunlight and air, and they behave differently to all other types of atmospheric reactions. This project aims to charact ....Atmospheric Photothermal Oxidation as a New Reaction in the Atmosphere. Atmospheric models provide crucial advice on the current and future impacts of human activity on the atmosphere. This project hypothesizes the presence of a new class of chemical reactions that are unknown in atmospheric science and therefore missing from the best existing models. The reactions require both sunlight and air, and they behave differently to all other types of atmospheric reactions. This project aims to characterise these reactions in the lab, understand them with theory, and quantify their global impact through modelling. Expected benefits include new understanding of atmospheric chemistry, more accurate model predictions, and—as a result—better strategies for managing the impacts of human activity on the environment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100381
Funder
Australian Research Council
Funding Amount
$444,000.00
Summary
Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australi ....Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australia and internationally by aiding development of early warning drug monitoring systems, providing the rapid deployment of interventions to reduce drug-related harm in the local community, while facilitating law and government agencies to better direct resources.Read moreRead less
Charging transition metals with activating alkanes. The project aims to engineer positively charged metal complexes and use them to explore the chemistry of bound activated alkane ligands. The transformation of cheap, plentiful alkanes into more valuable products is a major quest in chemistry, and complexes of alkanes bound to metals are expected to play a key role in transformations of alkanes. The project intends to use the activated metal bound alkane to transform the normally inert alkane in ....Charging transition metals with activating alkanes. The project aims to engineer positively charged metal complexes and use them to explore the chemistry of bound activated alkane ligands. The transformation of cheap, plentiful alkanes into more valuable products is a major quest in chemistry, and complexes of alkanes bound to metals are expected to play a key role in transformations of alkanes. The project intends to use the activated metal bound alkane to transform the normally inert alkane into compounds with desirable functional groups. This should make the synthesis of alkane complexes stable at room temperature in solution a realistic possibility. These cheap, plentiful alkanes can be turned into more valuable products, bringing benefits to industry.Read moreRead less
A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project ....A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project will result in a new and cost-effective approach for the identification, tracking and prioritisation of emerging chemical threats and address key national and global health risks. The outcomes include the first spatial and temporal distribution of new emerging chemical threats in Australia.Read moreRead less
Uncovering Antarctica’s Secret Chemical Voyagers for Expedited Regulation. This project aims to strengthen global chemical policy by rapidly identifying chemicals that demonstrate environmental persistence and mobility, two requisite risk criteria for regulatory action. It will take the novel approach of applying powerful non-target chemical screening approaches to Antarctic environmental media, leveraging the remoteness of Antarctica to derive unambiguous evidence against the key risk criteria. ....Uncovering Antarctica’s Secret Chemical Voyagers for Expedited Regulation. This project aims to strengthen global chemical policy by rapidly identifying chemicals that demonstrate environmental persistence and mobility, two requisite risk criteria for regulatory action. It will take the novel approach of applying powerful non-target chemical screening approaches to Antarctic environmental media, leveraging the remoteness of Antarctica to derive unambiguous evidence against the key risk criteria. Research will uncover a new catalogue of proven persistent and mobile chemicals, and further assess their ubiquity and biomagnification potential in the Antarctic system. Project findings will be directly disseminated to policymakers, facilitating expedited regulatory decision-making for improved Planetary Health outcomes.Read moreRead less
Developing a predictive toxicity model for metallic anions in plants. This project aims to develop competitive anionic toxicity models for antimony, arsenic, molybdenum and selenium supported by detailed speciation information. Available ecotoxicological models for inorganic toxicants have exclusively focused on cations such as zinc, and ignored anionic toxicants such as arsenic and antimony. For available models on cations to be applicable to contaminated environments, it is essential for equiv ....Developing a predictive toxicity model for metallic anions in plants. This project aims to develop competitive anionic toxicity models for antimony, arsenic, molybdenum and selenium supported by detailed speciation information. Available ecotoxicological models for inorganic toxicants have exclusively focused on cations such as zinc, and ignored anionic toxicants such as arsenic and antimony. For available models on cations to be applicable to contaminated environments, it is essential for equivalent anionic toxicity models be developed. This project will develop the first such model, which will provide new insights on ecotoxicological modelling for inorganic anionic toxicants. The project will transform ecotoxicological modelling approaches for metals and metalloids in terrestrial systems and directly improve our ability to assess risks associated with environmental contamination.Read moreRead less
Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-spe ....Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-specific chemical exposures in Australia, and globally. Such data are critical to inform public health and chemical regulation policy, and provide clear guidance aimed at reducing exposures, to assess the effectiveness of existing regulations, and provide a framework for implementing surveys in the future.Read moreRead less
Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lip ....Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lipid biology at the cellular and sub-cellular level across a wide range of in vitro and in vivo models. The outcomes of this project should provide significant knowledge to tackle modern societal challenges in healthy ageing, brain pathologies and neurodegenerative diseases.Read moreRead less
Programmable Organometallics for Spatiotemporal Light Control. This Project aims to develop new materials that control and modify light. The new organometallics from this Project are anticipated to display world record light intensity-dependent absorption and other phenomena. These new programmable molecules are expected to respond to environmental stimuli with precise spatial control. Anticipated outcomes of this Project include environmental sensors and a technology platform for targeted medic ....Programmable Organometallics for Spatiotemporal Light Control. This Project aims to develop new materials that control and modify light. The new organometallics from this Project are anticipated to display world record light intensity-dependent absorption and other phenomena. These new programmable molecules are expected to respond to environmental stimuli with precise spatial control. Anticipated outcomes of this Project include environmental sensors and a technology platform for targeted medical imaging and light-responsive therapies. This Project should provide significant benefits including possible commercialisation of the new materials, enhanced research capacity, training students and a postdoctoral fellow with unique skills, and the strengthening of research linkages with strategic partners.Read moreRead less