Expanding the organometallic toolbox for constructing heterocycles. This project aims to design and synthesise stereospecific cyclic molecules. This is a problem for chemists, particularly when bioactivity and medicinal relevance depend on complex stereochemistry and substitution patterns. This team will build on their discovery of a cascade reaction for synthesising highly stereospecific indolene derivatives. They will target reagents and reaction pathways for creating heterocyclic molecules wh ....Expanding the organometallic toolbox for constructing heterocycles. This project aims to design and synthesise stereospecific cyclic molecules. This is a problem for chemists, particularly when bioactivity and medicinal relevance depend on complex stereochemistry and substitution patterns. This team will build on their discovery of a cascade reaction for synthesising highly stereospecific indolene derivatives. They will target reagents and reaction pathways for creating heterocyclic molecules which are difficult to access. They will synthesise and characterise homo- and hetero-bimetallic complexes to develop cyclic molecules and scaffolds relevant in drug discovery. New molecules and reaction pathways will be relevant for biological and medicinal chemistry, and drug discovery programmes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101137
Funder
Australian Research Council
Funding Amount
$389,470.00
Summary
Synthesis, Structure and Utility of Novel P-chiral and C-chiral Organophosphido Metal Complexes . The formation of new molecules requires original methods to achieve their synthesis with greatest efficiency. Organometallic chemistry remains crucial for establishing novel reagents and processes. Driven by advances in organo-multi-metallic chemistry this project will build upon fundamental concepts in main group and transition metal chemistry to establish the area of phosphorous-chiral and carbon- ....Synthesis, Structure and Utility of Novel P-chiral and C-chiral Organophosphido Metal Complexes . The formation of new molecules requires original methods to achieve their synthesis with greatest efficiency. Organometallic chemistry remains crucial for establishing novel reagents and processes. Driven by advances in organo-multi-metallic chemistry this project will build upon fundamental concepts in main group and transition metal chemistry to establish the area of phosphorous-chiral and carbon-chiral organophosphido metal chemistry. By rationally designing and integrating new chiral phosphido ligands into mono- and mixed-metal organometallic complexes, chemists will have access to a suite of new tools for application in asymmetric synthesis and catalysis, all relevant to the fields of structural, sustainable and biological chemistry.Read moreRead less
Early main group organometallic complexes and their role in asymmetric synthesis. This project will develop new highly reactive metal based molecular tools for the controlled synthesis of complex molecules which are normally difficult to access, and in so doing advances our synthetic armoury. The design of the reaction pathways and final molecules will have relevance for modern medicinal chemistry and drug discovery programs.