Fluid mechanics and physiology of blockages in vascular systems. Vascular disease is a major health problem both in Australia and worldwide. In particular, cardiovascular disease is a major killer of adult Australians. Engineers and mathematicians working with biologists will gain a greater understanding of vascular diseases, a major health problem, including cardiovascular disease, which is one of the biggest killers worldwide, as well as tackling renal circulation problems, which are a signifi ....Fluid mechanics and physiology of blockages in vascular systems. Vascular disease is a major health problem both in Australia and worldwide. In particular, cardiovascular disease is a major killer of adult Australians. Engineers and mathematicians working with biologists will gain a greater understanding of vascular diseases, a major health problem, including cardiovascular disease, which is one of the biggest killers worldwide, as well as tackling renal circulation problems, which are a significant problem and may contribute to hypertension. Detailed measurement and prediction will be undertaken of the mechanical loading and response of cells to their microenvironment, an important first step to controlling pathological responses which lead to a variety of autoimmune problems.Read moreRead less
A Method to Characterise an Aberration-Corrected Electron Wave Field - a step towards quantitative electron microscopy. Australia has recently invested in a powerful, new electron microscope, one of the first in the world, which can image features at the atomic scale that could not be seen before. This project will forge a strategic partnership with the designer and the distributor of this microscope, to develop special new methods that will further increase the microscope's imaging power. This ....A Method to Characterise an Aberration-Corrected Electron Wave Field - a step towards quantitative electron microscopy. Australia has recently invested in a powerful, new electron microscope, one of the first in the world, which can image features at the atomic scale that could not be seen before. This project will forge a strategic partnership with the designer and the distributor of this microscope, to develop special new methods that will further increase the microscope's imaging power. This will give Australian scientists unique capabilities with which to investigate and engineer new materials for advanced technological applications and it will train young Australian scientists in these cutting-edge techniques.Read moreRead less
Characterisation and improvement of radiation beams used for radiotherapy of small lesions. This project aims to characterise the radiation dose from a medical linear accelerator after the beam has been shaped by a mini-multileaf collimator. The characterisation will be achieved through a combination of computer simulations and experimental investigation of the beam using the technique of three-dimensional gel dosimetry. When the dosage characteristics are known, techniques will be developed to ....Characterisation and improvement of radiation beams used for radiotherapy of small lesions. This project aims to characterise the radiation dose from a medical linear accelerator after the beam has been shaped by a mini-multileaf collimator. The characterisation will be achieved through a combination of computer simulations and experimental investigation of the beam using the technique of three-dimensional gel dosimetry. When the dosage characteristics are known, techniques will be developed to improve radiotherapy treatments in patients with small lesions with sizes of up to a few centimetres. This will lead to an improved outcome for some cancer patients.Read moreRead less
The Effect of Fuel Type on Health and Environmental Risks Caused by Motor Vehicle Emissions. Motor vehicles constitute one of the most significant sources of air pollutants but the state of knowledge on the quantity of some of these does not permit for projection of the risk they create. This project aims at quantification of emissions of pollutants contributing to deterioration of health, ozone formation, global warming and acid rain as a function of fuel type, using a novel on-road sampling m ....The Effect of Fuel Type on Health and Environmental Risks Caused by Motor Vehicle Emissions. Motor vehicles constitute one of the most significant sources of air pollutants but the state of knowledge on the quantity of some of these does not permit for projection of the risk they create. This project aims at quantification of emissions of pollutants contributing to deterioration of health, ozone formation, global warming and acid rain as a function of fuel type, using a novel on-road sampling method. Resultantly, a holistic picture of integrated health and environmental risk will be developed that will build a scientific foundation for future fuel,transport and land use to protect the community and the environment.Read moreRead less
Physical factors affecting deposition of combustion submicrometer particles in the human lung. Particles generated from combustion sources have a profound effect on human health, yet there is lack of scientific understanding of the role of different physical mechanisms on particle deposition in the lung. This program will advance scientific knowledge in this field through multidisciplinary efforts of a team from QUT and the University of Salzburg, Austria. It aims at quantification of particle d ....Physical factors affecting deposition of combustion submicrometer particles in the human lung. Particles generated from combustion sources have a profound effect on human health, yet there is lack of scientific understanding of the role of different physical mechanisms on particle deposition in the lung. This program will advance scientific knowledge in this field through multidisciplinary efforts of a team from QUT and the University of Salzburg, Austria. It aims at quantification of particle deposition in human lung through experimental studies and advanced modelling. The program will enhance and strengthen the existing collaboration between the universities and its outcome will be of significance in the vital area of human health and risk assessment.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775544
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
X-Ray Facility for 3-D High Resolution Diffraction Imaging of Nanostructures. Australian advances in quantitative x-ray imaging are at the leading edge of international efforts to permit 3D characterisation of the structure of materials and dynamic studies of structural changes. They have proven to be sensitive to local arrangement of materials at the nanometre scale, and they are emerging as critical tools in the development of advanced materials, which is a national research priority. This fac ....X-Ray Facility for 3-D High Resolution Diffraction Imaging of Nanostructures. Australian advances in quantitative x-ray imaging are at the leading edge of international efforts to permit 3D characterisation of the structure of materials and dynamic studies of structural changes. They have proven to be sensitive to local arrangement of materials at the nanometre scale, and they are emerging as critical tools in the development of advanced materials, which is a national research priority. This facility will allow the non-destructive 3D imaging of nanostructured materials to be performed as continual experimental development - something that is very difficult to achieve at synchrotron sources where access can be sporadic. The newly developed techniques will be applied to critical problems in emerging nanotechnologies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347970
Funder
Australian Research Council
Funding Amount
$186,000.00
Summary
Integrated Bio-nano-fabrication Facility. The project proposes the upgrade of a joint facility for the probing, fabrication and operation of hybrid bio-nano-devices. The facility will enhance the proposers' capabilities in the area of the fundamental and prototype-type research on biomolecular/cellular devices. The ultimate goal of these projects is to thrust Australian science in the era when the essential functions of cells can be replicated and controlled on devices that are smaller than livi ....Integrated Bio-nano-fabrication Facility. The project proposes the upgrade of a joint facility for the probing, fabrication and operation of hybrid bio-nano-devices. The facility will enhance the proposers' capabilities in the area of the fundamental and prototype-type research on biomolecular/cellular devices. The ultimate goal of these projects is to thrust Australian science in the era when the essential functions of cells can be replicated and controlled on devices that are smaller than living cells. The proposed facility has a modular structure consisting of additional nano-positioning, confocal microscope and zeta potential modules built on the existent laser tweezers/scissors, picoliter pipette and Atomic Force Microscope modules.Read moreRead less
Special Research Initiatives - Grant ID: SR0566602
Funder
Australian Research Council
Funding Amount
$87,933.00
Summary
Development of a collaborative online environment and workbench for the investigation of protein folding. The investigation of protein folding – one the most important unsolved biological problems, is generating large amounts of complex data. This proposal aims to develop a highly collaborative content management system and interactive data mining tools that will allow the open exchange and analysis of protein folding data. A chief goal of this proposal is, by creating a rich informatics envir ....Development of a collaborative online environment and workbench for the investigation of protein folding. The investigation of protein folding – one the most important unsolved biological problems, is generating large amounts of complex data. This proposal aims to develop a highly collaborative content management system and interactive data mining tools that will allow the open exchange and analysis of protein folding data. A chief goal of this proposal is, by creating a rich informatics environment, to foster the exchange of ideas and rapid dissemination of new data across the international array of groups working in parallel on various aspects of the folding problem.Read moreRead less
ARC/NHMRC Research Network Fluorescence Applications in Biotechnology and Life Sciences. This Network will concentrate Australian research in new applications of fluorescence to biological systems to solve significant problems in health diagnostics, biotechnology and the environment. The scientific goals identified by the Network such as highly selective fluorescent labelling and purpose-engineered fluorochromes will be accompanied by the development of specialised instrumentation. These resear ....ARC/NHMRC Research Network Fluorescence Applications in Biotechnology and Life Sciences. This Network will concentrate Australian research in new applications of fluorescence to biological systems to solve significant problems in health diagnostics, biotechnology and the environment. The scientific goals identified by the Network such as highly selective fluorescent labelling and purpose-engineered fluorochromes will be accompanied by the development of specialised instrumentation. These research directions pursued by strong multi-disciplinary teams spanning biology, chemistry, physics, bioengineering and medicine will benefit from the support of the Network programs. Through its focus on academic - industry collaboration the Network will also facilitate development of basic scientific discoveries into commercial outcomes.Read moreRead less