Novel Applied Bayesian Statistics for Monitoring Neuromuscular Diseases. Neurological diseases such as motor neurone disease are caused by the progressive death of motor units serving a muscle. Currently there are no ways of quantifying and detecting change in the number of motor units serving a muscle which are non-invasive. Our research will provide an objective method for the progression of neuromuscular diseases to be monitored with minimal inconvenience to patients. This will allow clinic ....Novel Applied Bayesian Statistics for Monitoring Neuromuscular Diseases. Neurological diseases such as motor neurone disease are caused by the progressive death of motor units serving a muscle. Currently there are no ways of quantifying and detecting change in the number of motor units serving a muscle which are non-invasive. Our research will provide an objective method for the progression of neuromuscular diseases to be monitored with minimal inconvenience to patients. This will allow clinical trials for possible effective treatments of neurological diseases such as motor neurone disease to be conducted with an objective measurement of disease progression. Read moreRead less
Sustaining neuronal communication through bulk endocytosis. Brain activities such as learning and memory rely on the ability of neurons to communicate. This research will improve our understanding of how synaptic vesicles recycle during periods of intense synaptic activity. This is a fundamental process relevant to neuronal communication, insulin release, hormone secretion, and allergic responses in health and disease and therefore has broad significance. This work will enhance Australia's exist ....Sustaining neuronal communication through bulk endocytosis. Brain activities such as learning and memory rely on the ability of neurons to communicate. This research will improve our understanding of how synaptic vesicles recycle during periods of intense synaptic activity. This is a fundamental process relevant to neuronal communication, insulin release, hormone secretion, and allergic responses in health and disease and therefore has broad significance. This work will enhance Australia's existing strength in cell biology and neuroscience and provide high quality training for an undergraduate student and post-doctoral scientist.Read moreRead less