Molecular evolution and toxinology of colubrid snake venom toxins. This project proposes to examine the origin and evolution of venom systems in advanced snakes (Caenophidia) focusing on the colubrid radiation comprising the rear-fanged species. Demonstration by us of the presence of a potent postsynaptic neurotoxin in the Durvenoy's secretions of the Asian ratsnake Elaphe radiata, an archetypal non-venomous colubrid species, forced a fundamental rethink of venom evolution. The toxin is homologo ....Molecular evolution and toxinology of colubrid snake venom toxins. This project proposes to examine the origin and evolution of venom systems in advanced snakes (Caenophidia) focusing on the colubrid radiation comprising the rear-fanged species. Demonstration by us of the presence of a potent postsynaptic neurotoxin in the Durvenoy's secretions of the Asian ratsnake Elaphe radiata, an archetypal non-venomous colubrid species, forced a fundamental rethink of venom evolution. The toxin is homologous with the three finger toxins, previously thought unique to elapids, and supports the role of venom as a key evolutionary innovation in the diversification of advanced snakes. This project extends this work to other species and toxin families.Read moreRead less
Optimising vascularisation of tissue engineering chambers for construction of robust tissues. We have produced a device that has commercial application in several fields of basic science, biotechnology and bioengineering. When its full potential is achieved, our innovative organ chamber will strengthen Australia's standing in the biotechnology field and enrich specific applications. The knowledge gained from understanding the growth of blood vessels will benefit several fields including chemical ....Optimising vascularisation of tissue engineering chambers for construction of robust tissues. We have produced a device that has commercial application in several fields of basic science, biotechnology and bioengineering. When its full potential is achieved, our innovative organ chamber will strengthen Australia's standing in the biotechnology field and enrich specific applications. The knowledge gained from understanding the growth of blood vessels will benefit several fields including chemical bioengineering, tissue engineering and repair, polymer chemistry, therapeutics in many areas (like cancer, heart disease, diabetes), hormone manufacture for agricultural, veterinary and medical purposes and cosmetics manufacture. The project will train several post-doctoral fellows and PhD students in this cutting edge field of researchRead moreRead less
Effective communication and improved patient safety: Addressing the complexities of managing high risk medications in metropolitan and regional hospitals. Current costs of hospital-related incidents are around AU$2 billion per year, and the most common cause of these incidents is ineffective communication. Medication incidents relating to use of high risk medications are particularly critical because of the increased severity of patient outcomes. High risk medications are administered in busy en ....Effective communication and improved patient safety: Addressing the complexities of managing high risk medications in metropolitan and regional hospitals. Current costs of hospital-related incidents are around AU$2 billion per year, and the most common cause of these incidents is ineffective communication. Medication incidents relating to use of high risk medications are particularly critical because of the increased severity of patient outcomes. High risk medications are administered in busy environments, and involve patients who are cared for by many different health professionals in technologically complex settings. These factors increase the likelihood of more medication incidents. The unique knowledge obtained will inform policies and identify strategies for better communication. Health professionals and patients can adopt these strategies to improve medication safety.Read moreRead less
The central nucleus of the amygdala and alcohol-seeking behaviour. Alcohol abuse and alcoholism is a significant problem in Australia (and throughout the world). However, pharmacological interventions remain limited due to our poor understanding of the neural networks underlying addictive processes. These experiments will explain how the positive rewarding and negative reinforcing aspects of alcohol are transduced within the brain. We believe that our research will facilitate the ability to trea ....The central nucleus of the amygdala and alcohol-seeking behaviour. Alcohol abuse and alcoholism is a significant problem in Australia (and throughout the world). However, pharmacological interventions remain limited due to our poor understanding of the neural networks underlying addictive processes. These experiments will explain how the positive rewarding and negative reinforcing aspects of alcohol are transduced within the brain. We believe that our research will facilitate the ability to treat alcoholism at a pharmacological level, enabling the continuation of abstinence or the prevention of relapse, while allowing other factors such as social support structure and coping skills to be developed for each individual, with flow-on social and economic benefits for society as a whole. Read moreRead less
New analgesics based on µ-conotoxins: structure-based design of helical mimetics. Diseases in which voltage-gated sodium channels are implicated are contributors to morbidity and mortality in the Australian population, and this project promises to provide new leads for the future development of drugs to treat such diseases, in particular analgesics for the treatment of chronic pain. The generation of these leads will entail the development of new approaches to mimicking key regions of peptides a ....New analgesics based on µ-conotoxins: structure-based design of helical mimetics. Diseases in which voltage-gated sodium channels are implicated are contributors to morbidity and mortality in the Australian population, and this project promises to provide new leads for the future development of drugs to treat such diseases, in particular analgesics for the treatment of chronic pain. The generation of these leads will entail the development of new approaches to mimicking key regions of peptides and proteins in drug-like molecules. This is a highly interdisciplinary project, spanning structural biology, molecular design, medicinal chemistry, molecular biology and electrophysiology, and the training of PhD graduates with such broad experience represents another national benefit of the project.Read moreRead less