Nanoscope-in-a-needle: nanoscale imaging and sensing deep inside tissue. This project seeks to make possible nanoscale and microscale imaging deep inside living human tissue. By miniaturising advanced optical imaging, sensing and spectroscopy systems into a hypodermic needle – a nanoscope-in-a-needle – it would be possible to study the structure and function of living biological systems in their native, three-dimensional environment up to centimetres deep in soft tissue but with unprecedented n ....Nanoscope-in-a-needle: nanoscale imaging and sensing deep inside tissue. This project seeks to make possible nanoscale and microscale imaging deep inside living human tissue. By miniaturising advanced optical imaging, sensing and spectroscopy systems into a hypodermic needle – a nanoscope-in-a-needle – it would be possible to study the structure and function of living biological systems in their native, three-dimensional environment up to centimetres deep in soft tissue but with unprecedented nano- and micro-scale resolution. A suite of new nanoscopes would underpin biological discovery and help advance human health and wellbeing.Read moreRead less
Plasmon mode lasers; smaller, faster, better. High speed Information Technology (IT) communication is using more and more of our global energy. Energy efficiency of IT hardware can be improved by incorporating small, high performance lasers for short distance optical communication. New metallic and plasmonic nano-lasers lasers are indeed smaller and in theory can have performance advantages over current dielectric cavity lasers. This project looks at developing new electrically pumped plasmonic ....Plasmon mode lasers; smaller, faster, better. High speed Information Technology (IT) communication is using more and more of our global energy. Energy efficiency of IT hardware can be improved by incorporating small, high performance lasers for short distance optical communication. New metallic and plasmonic nano-lasers lasers are indeed smaller and in theory can have performance advantages over current dielectric cavity lasers. This project looks at developing new electrically pumped plasmonic lasers with nano scale semiconductors that satisfy requirements for short distance optical communications. Complex systems of these small, fast lasers will also be investigated, with the aim of providing high speed digital processing capabilities exceeding those of electronics.Read moreRead less
Silicon-germanium-carbon - a novel opto-mechanic material for optical micro-electromechanical systems. Evolving from past black-and-white images, through present red-green-blue multi-spectral capability, future remote imaging systems promise spectroscopic functionality across much broader wavelength ranges in a low-cost system. However, the high cost of multiple materials and technologies for each specific spectral band limits them to high-cost industry sectors. This project proposes a simple, l ....Silicon-germanium-carbon - a novel opto-mechanic material for optical micro-electromechanical systems. Evolving from past black-and-white images, through present red-green-blue multi-spectral capability, future remote imaging systems promise spectroscopic functionality across much broader wavelength ranges in a low-cost system. However, the high cost of multiple materials and technologies for each specific spectral band limits them to high-cost industry sectors. This project proposes a simple, low-cost, single material technology based on silicon-germanium-carbon thin films for mechanical and optical applications from ultraviolet to long-wave infrared, enabling widespread application of spectroscopic imaging to multiple fields extending from climate change research, through resource exploration, to cancer detection, and aerospace/defense.Read moreRead less
Adaptive multispectral imaging system for remote sensing applications. The many applications of remote sensing include environmental/crop monitoring, oil/mineral exploration, and aerospace/defence. However, remote sensing stands to benefit greatly from infrared spectral imaging devices. This project will develop the technology for an infrared spectral imaging system, suitable for numerous remote sensing applications.
Interrogating protein hydration by terahertz time-domain spectroscopy. Interrogating protein hydration by terahertz time-domain spectroscopy. This project aims to develop advanced terahertz time-domain spectroscopy (THz-TDS) techniques to understand how a protein’s interaction with excipients in solution can alter the hydration layers around them and how this affects properties such as viscosity and stability. THz-TDS can detect overlapping extended hydration layers around proteins, revealing ne ....Interrogating protein hydration by terahertz time-domain spectroscopy. Interrogating protein hydration by terahertz time-domain spectroscopy. This project aims to develop advanced terahertz time-domain spectroscopy (THz-TDS) techniques to understand how a protein’s interaction with excipients in solution can alter the hydration layers around them and how this affects properties such as viscosity and stability. THz-TDS can detect overlapping extended hydration layers around proteins, revealing new knowledge in protein-protein interactions and protein behaviour in an aqueous environment. The intended outcome is to use THz-TDS to better understand how proteins such as monoclonal antibodies interact in high concentration solutions, and in doing so make better medicines.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100134
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Integrated photodetector array fabrication facility. Sensing is becoming a ubiquitous requirement for nearly all physical, chemical and biological research fields, and is increasingly important for Australia's national security and industry competitiveness. This proposal is aimed at building Australia's strengths in optoelectronic sensing technologies, enhancing and enabling research and technologies for innovative environmental monitoring, medical diagnostics, new technologies for mineral expl ....Integrated photodetector array fabrication facility. Sensing is becoming a ubiquitous requirement for nearly all physical, chemical and biological research fields, and is increasingly important for Australia's national security and industry competitiveness. This proposal is aimed at building Australia's strengths in optoelectronic sensing technologies, enhancing and enabling research and technologies for innovative environmental monitoring, medical diagnostics, new technologies for mineral exploration and improved evaluation of remediation of mine sites, through to the surveillance and sensing needs of customs, defence and national security. In doing so, it will enhance Australia's research profile as one of the world's leaders in the development and use of optoelectronic sensing.Read moreRead less
Ultra-high spectral purity lasers for tests of relativity and atomic clocks. Measurement precision is the key to advancement of a technological society. This project aims to build the most precise measurement tool ever developed: one capable of delivering 17 digits of precision in just 1 second. In conjunction with German and French colleagues this too will be used to test the foundation theories of physics.
Three dimensional (3D) optical coherence tomography in cancer. This project will establish for the first time how well 3D optical coherence tomography, a form of medical imaging, can image cancer. Based on this, a version built into a needle will be developed which will enable extension much deeper into tissues than previously possible to image cancer and to guide related surgical procedures.
Combined Terahertz Imaging and Optical Coherence Tomography. This project aims to exploit the synergies between terahertz imaging and optical coherence tomography. These novel imaging modalities will be combined into a single multi-modality technique which will have application in numerous industry sectors like manufacturing, non-destructive testing, pharmaceutical and medicine. The intended outcome of the project is to create an internationally leading position for Australia in cutting-edge res ....Combined Terahertz Imaging and Optical Coherence Tomography. This project aims to exploit the synergies between terahertz imaging and optical coherence tomography. These novel imaging modalities will be combined into a single multi-modality technique which will have application in numerous industry sectors like manufacturing, non-destructive testing, pharmaceutical and medicine. The intended outcome of the project is to create an internationally leading position for Australia in cutting-edge research in optical and terahertz imaging. This innovative, fundamental research will expand Australia’s research capacity in imaging with wide ranging applications. The anticipated goal of the project is to build a prototype imaging system with industry partners ready for the next step to commercialisation. Read moreRead less
Biological applications of terahertz technology. This project aims to develop new knowledge for exploring the interaction of terahertz (THz) radiation with different materials. THz technology is in use in diverse applications from security screening to biomedical imaging. A hurdle to the widespread adoption of the technology is the poor understanding of the basic interaction between THz radiation and molecules, proteins, cells and tissues. This project will enable development of advanced THz tec ....Biological applications of terahertz technology. This project aims to develop new knowledge for exploring the interaction of terahertz (THz) radiation with different materials. THz technology is in use in diverse applications from security screening to biomedical imaging. A hurdle to the widespread adoption of the technology is the poor understanding of the basic interaction between THz radiation and molecules, proteins, cells and tissues. This project will enable development of advanced THz technology and applications and will lead to accelerated implementation for use in chemistry, biology and, ultimately, medicalapplications such as cancer detection.Read moreRead less