ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Pharmacological and biochemical characterisation of Australian mygalomorph spider venoms. This project will increase our limited knowledge of Australian mygalomorph venoms by isolation, identification and characterisation of novel toxins in theraphosid and Northern mouse-spider venoms. Thereby, the scientific basis for the treatment of mygalomorph spider bites might be improved. Secondly, new insights into pharmacology and the potential development of novel therapeutics and molecular probes of t ....Pharmacological and biochemical characterisation of Australian mygalomorph spider venoms. This project will increase our limited knowledge of Australian mygalomorph venoms by isolation, identification and characterisation of novel toxins in theraphosid and Northern mouse-spider venoms. Thereby, the scientific basis for the treatment of mygalomorph spider bites might be improved. Secondly, new insights into pharmacology and the potential development of novel therapeutics and molecular probes of target molecules might be expected.Read moreRead less
Predicting the Impact of Damming on the Endangered Mary River Turtle. Little is known about the effects of inland river alteration on the ecology of freshwater turtles, where river damming results in dramatic changes in river physical, chemical and biological characteristics. In Australia there are 446 large dams, necessary for hydro-electric power, navigation, flood control, irrigation and drinking water. Many of these rivers are inhabited by freshwater turtles, endemic to Australia, and this ....Predicting the Impact of Damming on the Endangered Mary River Turtle. Little is known about the effects of inland river alteration on the ecology of freshwater turtles, where river damming results in dramatic changes in river physical, chemical and biological characteristics. In Australia there are 446 large dams, necessary for hydro-electric power, navigation, flood control, irrigation and drinking water. Many of these rivers are inhabited by freshwater turtles, endemic to Australia, and this project will assess the impact of changes in habitat quality on the endangered Mary River Turtle (Elusor macrurus). The study comes at a timely opportunity, as proposed river damming will substantially alter the turtles' habitat, and its survival potential remains unknown.Read moreRead less
Calcium regulation in the skeletal muscle triad and along the fibre. The fundamental role of skeletal muscle is posture and movement. Alterations in the normal way calcium regulates skeletal muscle function in fatigue, age and disease states causes loss of normal function. Preventing or controlling these changes is a key therapeutic aim. However, we currently lack full understanding of key mechanisms of calcium regulation in healthy skeletal muscle. This project will define key aspects of cal ....Calcium regulation in the skeletal muscle triad and along the fibre. The fundamental role of skeletal muscle is posture and movement. Alterations in the normal way calcium regulates skeletal muscle function in fatigue, age and disease states causes loss of normal function. Preventing or controlling these changes is a key therapeutic aim. However, we currently lack full understanding of key mechanisms of calcium regulation in healthy skeletal muscle. This project will define key aspects of calcium regulation that could be crucial to developing targets for improving function of skeletal muscle under stressed states.Read moreRead less
The role of algal endosymbionts in acclimation and adaptation of reef corals to climate change. Understanding the potential of symbiotic zooxanthellae to enhance the thermal tolerance of reef corals addresses our first national Research Priority Goal aimed at the sustainable use of Australia's biodiversity. Given current trends in global warming, such knowledge is critical to underpinning the long-term management of the Great Barrier Reef, which has significant political and socio-economic impor ....The role of algal endosymbionts in acclimation and adaptation of reef corals to climate change. Understanding the potential of symbiotic zooxanthellae to enhance the thermal tolerance of reef corals addresses our first national Research Priority Goal aimed at the sustainable use of Australia's biodiversity. Given current trends in global warming, such knowledge is critical to underpinning the long-term management of the Great Barrier Reef, which has significant political and socio-economic importance on local, state, national and global scales for services ranging from fisheries to ecotourism. Understanding the potential for corals to form associations with different genetic types of zooxanthellae will significantly advance current knowledge of the likelihood that animals can adapt to climate change.Read moreRead less