Elucidating the mechanisms by which Scribble, Discs Large and Lethal Giant Larvae regulate epithelial polarity. Discs Large (Dlg) and Scribble are proteins that regulate cell shape by concentrating at particular regions within the cell and recruiting other proteins to that region. It is thought that the two proteins interact with each other, and with other proteins involved in protein trafficking and cell architecture, but it is not known how these events coordinate to produce a net outcome on ....Elucidating the mechanisms by which Scribble, Discs Large and Lethal Giant Larvae regulate epithelial polarity. Discs Large (Dlg) and Scribble are proteins that regulate cell shape by concentrating at particular regions within the cell and recruiting other proteins to that region. It is thought that the two proteins interact with each other, and with other proteins involved in protein trafficking and cell architecture, but it is not known how these events coordinate to produce a net outcome on cell shape. To answer these questions, the dynamic events involved in localization of Dlg, Scribble, and associated proteins will be determined, in mammalian cells and in whole organs of the vinegar fly.Read moreRead less
Integrated Atom Optics: Guiding Matter Waves with Magnetic Microstructures. The development of micron-scale waveguides that coherently transport, split and recombine atom de Broglie waves is important for atom optics and interferometry. Atom interferometers will be used for fundamental tests of quantum physics and as inertial sensors for the detection of gravitational anomalies. The expected outcomes include microfabrication of integrated atom devices that produce coherent matter waves via Bose- ....Integrated Atom Optics: Guiding Matter Waves with Magnetic Microstructures. The development of micron-scale waveguides that coherently transport, split and recombine atom de Broglie waves is important for atom optics and interferometry. Atom interferometers will be used for fundamental tests of quantum physics and as inertial sensors for the detection of gravitational anomalies. The expected outcomes include microfabrication of integrated atom devices that produce coherent matter waves via Bose-Einstein condensation and utilise them in a new generation of atom interferometers.Read moreRead less
Advancing x-ray imaging into new dimensions using interferometry and phase-space tomography. Synchrotron science and nanofabrication technologies are priority investment areas for most industrial countries including Australia. This research program takes advantages of recent progress in these fields and aims to advance x-ray imaging techniques of high sensitivity and low radiation dose and retrieve all extractable information of an object encoded in a wavefield. The development of these techniqu ....Advancing x-ray imaging into new dimensions using interferometry and phase-space tomography. Synchrotron science and nanofabrication technologies are priority investment areas for most industrial countries including Australia. This research program takes advantages of recent progress in these fields and aims to advance x-ray imaging techniques of high sensitivity and low radiation dose and retrieve all extractable information of an object encoded in a wavefield. The development of these techniques is critical to future opportunities of frontier discoveries of the biological, nano and atomic world. Its application includes structural biology, medical diagnosis, biomedicine, material sciences and many other fields.Read moreRead less
Solid Light: Frontiers and applications of solid-state Cavity Quantum Electro-Dynamics. Our understanding of quantum mechanics directly fuels new technology. We are on the verge of a new revolution in technology, where the aspects of quantum physics that we haven't been able to understand are now within technological reach. Our concept of solid-light joins two of the most important branches of physics, and in so doing develops a new technology of diamond-based quantum processors that will be b ....Solid Light: Frontiers and applications of solid-state Cavity Quantum Electro-Dynamics. Our understanding of quantum mechanics directly fuels new technology. We are on the verge of a new revolution in technology, where the aspects of quantum physics that we haven't been able to understand are now within technological reach. Our concept of solid-light joins two of the most important branches of physics, and in so doing develops a new technology of diamond-based quantum processors that will be built in Australia. This will benefit the Australian scientific community by providing devices to solve important quantum problems, and benefit the wider community by growing a new industry based around diamond quantum nanoscience.Read moreRead less
Critical Tests of Quantum Electro-Dynamics (QED) in heavy atomic systems. The 2005 Nobel prize was awarded for high-precision spectroscopy and a critical test of QED in light atomic systems. This led to dramatic applications to constants of nature and Quantum Optics. Our research has also developed state-of-the-art detector and spectrometer technology in pursuit of fundamental knowledge, but in the X-ray regime. We will make major progress for heavy atomic systems. Applications include the deve ....Critical Tests of Quantum Electro-Dynamics (QED) in heavy atomic systems. The 2005 Nobel prize was awarded for high-precision spectroscopy and a critical test of QED in light atomic systems. This led to dramatic applications to constants of nature and Quantum Optics. Our research has also developed state-of-the-art detector and spectrometer technology in pursuit of fundamental knowledge, but in the X-ray regime. We will make major progress for heavy atomic systems. Applications include the development of a few-electron calibration lamp, widely discussed as a new energy standard. These studies provide data, physical insights and highly skilled personnel for Australia's future in frontier technologies. Our fundamental research has led to two orders of magnitude improvement in mammographic diagnostic accuracy.Read moreRead less
Development of a neutral helium beam microscope. This project would demonstrate Australia's capability in developing leading edge technologies applicable to the growing nanotechnology industry. The development of a neutral helium beam microscope brings into Australia expertise in the emerging field of molecular optics, and would place Australia as one of the first countries to make a commitment to this field. The project will develop a prototype instrument which is aimed at becoming a commercial ....Development of a neutral helium beam microscope. This project would demonstrate Australia's capability in developing leading edge technologies applicable to the growing nanotechnology industry. The development of a neutral helium beam microscope brings into Australia expertise in the emerging field of molecular optics, and would place Australia as one of the first countries to make a commitment to this field. The project will develop a prototype instrument which is aimed at becoming a commercially viable product - the neutral helium beam microscope. The possibilities of using the microscope system as a nanofabrication device would also give researchers in Australia the ability to fabricate structures that could not be manufactured anywhere else in the world.Read moreRead less
Diamond based single spin detector. It is expected that the development of the diamond based spin detector will further enhance Australia's international reputation as a significant contributor to the broad field of nanotechnology. The spin detection technology will have many applications in a variety of fields that rely on nanoscale precision measurement of single quantum systems.
Single spin detection will also be a pivotal tool in the push to produce quantum information technologies, a fi ....Diamond based single spin detector. It is expected that the development of the diamond based spin detector will further enhance Australia's international reputation as a significant contributor to the broad field of nanotechnology. The spin detection technology will have many applications in a variety of fields that rely on nanoscale precision measurement of single quantum systems.
Single spin detection will also be a pivotal tool in the push to produce quantum information technologies, a field that has been invested in heavily by the Australian government. This device will significantly enhance the potential success of a range of projects related to such nanoscale science.
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New Multidimensional Femtosecond Spectroscopic Techniques for Complex Molecular Systems. We will develop novel multidimensional nonlinear spectroscopic techniques based on sequences of femtosecond laser pulses to investigate ultrafast processes and transient species in complex molecular systems. The molecular systems will include biologically important protein molecules, complex synthetic polymers, new semiconductor materials and semiconductor quantum structures including quantum dots. This in ....New Multidimensional Femtosecond Spectroscopic Techniques for Complex Molecular Systems. We will develop novel multidimensional nonlinear spectroscopic techniques based on sequences of femtosecond laser pulses to investigate ultrafast processes and transient species in complex molecular systems. The molecular systems will include biologically important protein molecules, complex synthetic polymers, new semiconductor materials and semiconductor quantum structures including quantum dots. This information will significantly advance our understanding of fundamental dynamical processes such as energy and charge transfer in macro- and supra-molecules, transport of oxygen in animals, photosynthesis, advanced photo-active devices, and ultrafast processes in new semiconductor materials and semiconductor quantum structures.Read moreRead less
Diamond Single Photon Source. This project will enhance Australia's international profile in the area of quantum technology and will link, for the first time, diamond single photon capability with fibre optics technology, building on the strengths of both fields. The innovative steps in photonics and materials science which we are initiating place us in a unique position to exploit the emerging niche market for single photon sources. A provisional patent application for this technology is bein ....Diamond Single Photon Source. This project will enhance Australia's international profile in the area of quantum technology and will link, for the first time, diamond single photon capability with fibre optics technology, building on the strengths of both fields. The innovative steps in photonics and materials science which we are initiating place us in a unique position to exploit the emerging niche market for single photon sources. A provisional patent application for this technology is being lodged by the applicant and University of Melbourne colleagues in conjunction with QUCOR Pty Ltd. Success in researching and developing this device will help consolidate Australia's reputation as a global contributor to leading edge science and technology. Read moreRead less
Many-body physics with atomic Bose gases. Interdisciplinary research in science is promising new and revolutionary developments that may ultimately impact our daily lives. One such area, where the blurring of the boundaries between two disciplines could result in significant advancement of understanding and development of novel technologies, is the overlap of condensed matter or solid-state physics with atomic physics. This proposal seeks to put Australian science at the forefront of this new an ....Many-body physics with atomic Bose gases. Interdisciplinary research in science is promising new and revolutionary developments that may ultimately impact our daily lives. One such area, where the blurring of the boundaries between two disciplines could result in significant advancement of understanding and development of novel technologies, is the overlap of condensed matter or solid-state physics with atomic physics. This proposal seeks to put Australian science at the forefront of this new and exciting area of research. As a result, Australia will have a significant international presence, researchers will receive the cutting edge training necessary to be competitive with other countries and Australia will be poised to exploit the potentially beneficial developments.Read moreRead less