Enabling aerosol delivery of phages to defeat antibiotic-resistant bacteria. This project aims to explore the use of bacteriophages towards producing a safe, natural, and highly effective alternative to traditional antibiotics. Respiratory infections caused by multidrug-resistant Gram-negative bacteria are a major health problem worldwide, and cost Australia over $150 million annually. Some 5,000 Australians die each year from antibiotic resistant infections. The project aims to produce efficac ....Enabling aerosol delivery of phages to defeat antibiotic-resistant bacteria. This project aims to explore the use of bacteriophages towards producing a safe, natural, and highly effective alternative to traditional antibiotics. Respiratory infections caused by multidrug-resistant Gram-negative bacteria are a major health problem worldwide, and cost Australia over $150 million annually. Some 5,000 Australians die each year from antibiotic resistant infections. The project aims to produce efficacious and stable formulations of bacteriophages for easy delivery by inhalation as aerosols with a long shelf-life, making them a commercially viable product. The expected research outcome can lead to an economic and efficient technology to produce phage powders for novel treatment strategies of infections by inhalation.Read moreRead less
The role of electrostatic charge in airway deposition of aerosols. This project aims to unravel the importance of electrostatic charge in controlling deposition of aerosols in the respiratory tract. The expected outcome is a validated mathematical model for accurately predicting deposition behaviour of charged aerosol particles in human airways. Findings may ultimately be used to underpin novel prevention measures to reduce lung deposition of inhaled hazardous airborne particles to significantly ....The role of electrostatic charge in airway deposition of aerosols. This project aims to unravel the importance of electrostatic charge in controlling deposition of aerosols in the respiratory tract. The expected outcome is a validated mathematical model for accurately predicting deposition behaviour of charged aerosol particles in human airways. Findings may ultimately be used to underpin novel prevention measures to reduce lung deposition of inhaled hazardous airborne particles to significantly reduce health risks and costs. They may also be used to enable the development of new inhalation technologies based on electrostatic charge to improve aerosol drug delivery to the lungs of patients with respiratory diseases.Read moreRead less