Advanced water treatment technologies to minimise nitrogenous disinfection by-products in drinking water: understanding the role of organic nitrogen. This project will identify improved methods for treatment of drinking water to prevent the formation of potentially hazardous disinfection by-products. It will assist water resource managers and regulators to select the most economical and safe treatment for each type of water source and to plan for future demands on our limited water supplies.
Visualising below the tip of the proteome iceberg. Proteomics attempts to understand human biology by examining the protein components of cells and tissues. Unfortunately, currently available technology only allows approximately 10% of the complexity of these cells and tissues to be concurrently investigated. This project will the physical, chemical and functional properties of protein classes for enrichment, as well as improve technologies for protein visualization, identification and character ....Visualising below the tip of the proteome iceberg. Proteomics attempts to understand human biology by examining the protein components of cells and tissues. Unfortunately, currently available technology only allows approximately 10% of the complexity of these cells and tissues to be concurrently investigated. This project will the physical, chemical and functional properties of protein classes for enrichment, as well as improve technologies for protein visualization, identification and characterization. These approaches will allow the scientific community to further mine beneath the surface of the proteomics 'iceberg'.Read moreRead less
Identification and isolation of new pharmaceutical opiate analogues: today's problems tomorrow's solutions. This project will identify and characterise the impurity profiles across opiate alkaloid production, which will enhance the development of manufacturing processes through the reduction of problem impurities and provide potential new drug substances from the isolation of other opiate derived concomitant species.
Selective enrichment of proteins using micro-Gradiflow technology and characterisation of proteins using LC-MS/MS. This project describes crucial areas for the technology development of protein enrichment and fractionation. While current techniques are powerful, the usefulness to identify and characterise proteins of low abundance from massively complex samples in the presence of abundant proteins is limited and requires up to mililitre volumes. We intend to develop the micro-Gradiflow technolog ....Selective enrichment of proteins using micro-Gradiflow technology and characterisation of proteins using LC-MS/MS. This project describes crucial areas for the technology development of protein enrichment and fractionation. While current techniques are powerful, the usefulness to identify and characterise proteins of low abundance from massively complex samples in the presence of abundant proteins is limited and requires up to mililitre volumes. We intend to develop the micro-Gradiflow technology in association with Gradipore as a means of protein fractionation using microlitre volumes of sample. This technology will be applicable to all areas of proteomic research and in particular to the study of cell differentiation. The outcome for Australian industry, our competitiveness both industrial and scientific, and the potential for economic advancement is tremendous.Read moreRead less
Selective Detection and Removal of Contaminants That Have an Adverse Impact on Australian Raw Sugar Quality. Sugar is Australia's 2nd largest agricultural crop with 80-85% exported earning $2 billion in export revenue. Whilst Australia is arguably the most reliable supplier of premium raw sugar the implementation of improved processing technologies by rivals has (and without appropriate research strategies will continue to) eroded some of the long-held Australian advantages.
Our innovative a ....Selective Detection and Removal of Contaminants That Have an Adverse Impact on Australian Raw Sugar Quality. Sugar is Australia's 2nd largest agricultural crop with 80-85% exported earning $2 billion in export revenue. Whilst Australia is arguably the most reliable supplier of premium raw sugar the implementation of improved processing technologies by rivals has (and without appropriate research strategies will continue to) eroded some of the long-held Australian advantages.
Our innovative approaches will improve raw sugar quality, measurement methods, and allow new product development (value adding), enabling Australia to maintain its? world leading position. Importantly, our technologies enable improvements of specific quality issues (and potentially as yet unidentified issues), further differentiating the Australian product in the international marketplace.
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