The systems biology of stem cells. Using new bioinformatic methods, this project aims to identify new classifiers of different stem cell populations, develop statistical models that address population heterogeneity and provide molecular predictors of the differentiation potential of stem cells. Understanding, predicting and directing the processes of differentiation are major goals in the disciplines of stem cell biology, developmental biology, tissue engineering and regenerative medicine. Molec ....The systems biology of stem cells. Using new bioinformatic methods, this project aims to identify new classifiers of different stem cell populations, develop statistical models that address population heterogeneity and provide molecular predictors of the differentiation potential of stem cells. Understanding, predicting and directing the processes of differentiation are major goals in the disciplines of stem cell biology, developmental biology, tissue engineering and regenerative medicine. Molecular atlas projects have successfully revealed rules of genome output and regulation, by mining patterns that are evident across multiple cell types and datasets. By applying this philosophy to relevant, well-curated stem cell experiments, this project aims to create new methods for the integration and interrogation of smaller individual datasets. These methods should have broad utility and enable new avenues in tissue engineering.Read moreRead less
Accurate analysis of combinatorial problems: from the particular to the general. Combinatorial problems pervade all aspects of our social, environmental and economic life, but finding good solutions to these problems can take too much computer time. This project will develop new analysis tools that are effective at reducing this time, thus allowing for better solutions to be found.
Facilitating business process standardisation and reuse. One of the most pressing management challenges of today's organisations lies in the reuse and standardisation of best practices across different sectors, products or units. This project will develop an innovative open-source software platform and governance structure to efficiently and effectively support best practice standardisation and reuse.
Making the Pilbara blend: agile mine scheduling through contingent planning. Mine scheduling is a challenging problem for Rio Tinto which annually mines more than 200 Million tonnes of iron ore. This project will develop agile scheduling techniques of great economic importance to Australia. Carefully planned scheduling reduces infrastructure and minimises environmental impacts, maximising regeneration after mining.
Information Systems (IS)-Impact utility and intuitiveness: a rigorous approach to relevance. This study aims to evaluate the key elements of models used in design science to assess the impact of information systems. The work will examine the extent to which rigour and relevance are incorporated into these models.
Digital noticeboards for remote Aboriginal communities: bringing web 2.0 participation to non-western cultures with low English and technical literacy. Remote Aboriginal communities suffer from geographic and cultural isolation. Web 2.0 offers a solution yet is ill-suited to traditional collective cultures, those with low English and technical literacy, and the poor. This project will produce novel public web-enabled touchscreen noticeboards and table tops suited to traditional cultures.
Designing, implementing and evaluating a youth mobile help-seeking tool-kit. This project aims to design, implement and test a novel model of integrated mental health service that links a new mobile interactive tool-kit for self-directed help-seeking with existing traditional helpline services for young people. In partnership with Australia’s largest youth counselling service, Kids Helpline, the project seeks to investigate mobile technology in youth counselling and develop new understandings of ....Designing, implementing and evaluating a youth mobile help-seeking tool-kit. This project aims to design, implement and test a novel model of integrated mental health service that links a new mobile interactive tool-kit for self-directed help-seeking with existing traditional helpline services for young people. In partnership with Australia’s largest youth counselling service, Kids Helpline, the project seeks to investigate mobile technology in youth counselling and develop new understandings of blended traditional and mobile mental health interventions. It aims to design and evaluate an interactive tool-kit that provides credible health information through mobile devices, improving the quality and credibility of digital services to benefit the wellbeing of young Australians.Read moreRead less
Unlocking the potential for linear and discrete optimisation in knot theory and computational topology. Computational topology is a young, energetic field that uses computers to solve complex geometric problems, such as whether a loop of string is tangled. Such computations are becoming increasingly important in mathematics, and applications span biology, physics and information sciences, however many core problems in the field remain intractable for all but the simplest cases. This project unit ....Unlocking the potential for linear and discrete optimisation in knot theory and computational topology. Computational topology is a young, energetic field that uses computers to solve complex geometric problems, such as whether a loop of string is tangled. Such computations are becoming increasingly important in mathematics, and applications span biology, physics and information sciences, however many core problems in the field remain intractable for all but the simplest cases. This project unites geometric techniques with powerful methods from operations research, such as linear and discrete optimisation, to build fast, powerful tools that can for the first time systematically solve large topological problems. Theoretically, this project has significant impact on the famous open problem of detecting knottedness in fast polynomial time.Read moreRead less
Estimation of Complex Networked Dynamic Systems. An essential part of science and engineering is the development of mathematical models to describe how observed quantities relate to one another. For example, such models have proven to be extremely powerful in predicting the value of financial instruments, in providing high performance control of robots, and in detecting faults or changes in petrochemical processing plants. Constructing these models based on measurements from the system itself is ....Estimation of Complex Networked Dynamic Systems. An essential part of science and engineering is the development of mathematical models to describe how observed quantities relate to one another. For example, such models have proven to be extremely powerful in predicting the value of financial instruments, in providing high performance control of robots, and in detecting faults or changes in petrochemical processing plants. Constructing these models based on measurements from the system itself is known as system identification. This project is directed at developing new system identification methods for situations that, on the one hand, have previously been considered unsolvable, and on the other, are acknowledged as being of high practical interest.Read moreRead less
Learning to see in 3D. The project aims to endow machine vision with an ability we, as humans, use almost constantly: to judge 3D properties from a 2D image. This extremely useful ability will be applied to digital images to obtain 3D measurements and aid in automating tasks such as mining, surveying, medical diagnosis, and visual effects in movies.